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Ranitidine freeze-dried powder injection for curing gastropathy

A technology of ranitidine and freeze-dried excipients, which is applied in the field of ranitidine freeze-dried powder injection for the treatment of stomach diseases, and can solve the problems of high early recurrence rate

Active Publication Date: 2013-10-02
CHENGDU TIANTAISHAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Smokers have a higher rate of early relapse

Method used

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  • Ranitidine freeze-dried powder injection for curing gastropathy
  • Ranitidine freeze-dried powder injection for curing gastropathy
  • Ranitidine freeze-dried powder injection for curing gastropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] Embodiment 1: preparation pharmaceutical composition

[0165] Recipe (per bottle):

[0166] Ranitidine

100mg,

Mannitol

75 mg,

pH regulator

Appropriately adjust the pH to 5.5,

Dosing solution (10% ethanol)

1.5ml。

[0167] Preparation method: (a) Weigh the prescribed amount of ranitidine and mannitol, add about 85% of the formula amount of the formulation solvent, stir to dissolve, then add 0.1% activated carbon, stir for 30 minutes, filter and decarbonize;

[0168] (b) Add the above-mentioned liquid preparation solvent to its prescription amount, stir evenly, measure the pH value of the solution and optionally measure the active ingredient content, and adjust the solution to a value where the pH meets the requirements with an acid-base regulator if necessary (that is, take The filtrate is diluted with water for injection in an appropriate amount to contain active ingredient 20mg / ml, and the pH value of the diluted s...

Embodiment 2

[0173] Embodiment 2: preparation pharmaceutical composition

[0174] formula:

[0175] Ranitidine

[0176] Dosing solution (15% ethanol)

[0177] Preparation method: basically prepared according to the method of Example 1, using freeze-drying curve B during freeze-drying.

Embodiment 3

[0178] Embodiment 3: preparation pharmaceutical composition

[0179] formula:

[0180] Ranitidine

[0181] Preparation method: basically prepared according to the method of Example 1.

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Abstract

The invention relates to ranitidine freeze-dried powder injection for curing gastropathy, in particular to a medicine composition. The powder injection comprises ranitidine, freeze-dry excipient and optional PH modifier, wherein the freeze-dry excipient is selected from mannitol, lactose, cane sugar, glucose, sorbitol, glycine, dextran, salt and the combinations thereof. The medicine composition comprises the following materials by 100 weight parts of ranitidine: 20-200 parts of freeze-dry excipient. The medicine composition is dissolved and diluted by water to an extent that 20 mg ranitidine is contained in the solution of 1ml, and the pH value of the solution is 4.5-6.5. The medicine composition has the advantages of superior pharmaceutical characters including favorable chemical stability.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a potent histamine H2 receptor antagonist, which can effectively inhibit the secretion of gastric acid stimulated by histamine, pentagastrin and carbachol, and reduce gastric acid and The gastric enzyme activity is mainly used as an excellent stomach disease drug for the treatment of hyperacidity and heartburn, and in particular relates to a ranitidine hydrochloride powder injection for injection, which has good pharmaceutical properties. Background technique [0002] The ranitidine involved in the present invention (used clinically with its hydrochloride, when referring to ranitidine in the present invention, if not otherwise specified, all refer to its hydrochloride, Ranitidine Hydrochloride) is a kind of It can effectively inhibit the secretion of gastric acid stimulated by histamine, pentagastrin and carbamylcholine, and reduce the activity of gastric acid a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/341A61K47/26A61K47/18A61K47/10A61K47/02A61P1/04
Inventor 赵东明贾红军谷娟潘旭张莲莲董国明
Owner CHENGDU TIANTAISHAN PHARMA
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