Use of pyrazolopyrimidine compound in pharmacy

Abstract

The invention relates to a use of a pyrazolopyrimidine compound in treatment on candida albicans-infected diseases. The pyrazolopyrimidine compound is N3-(4-fluoropentyl)-1H-pyrazolo[3,4-D]pyrimidine-3,4-diamine. The pyrazolopyrimidine compound has good activity of resisting various shallow and deep fungi. Compared with the existing antifungal drugs in clinical application, the pyrazolopyrimidine compound has the advantages of high efficiency, low toxicity and wide antifungal spectrum and can be used for preparation of antifungal drugs.

Description

technical field [0001] The present invention relates to the application of a compound, in particular to the application of a thalazopyrimidine compound. Background technique [0002] Fungal infectious diseases are divided into four categories according to the parts of the fungus that invade the human body: superficial mycosis, skin mycosis, subcutaneous tissue mycosis and systemic mycosis; the former two are collectively called superficial mycosis, and the latter two are also called For deep mycoses. Fungal infectious diseases are divided into the following types according to different fungi: Candida albicans infectious disease, Candida parapsilosis infectious disease, Candida glabrata infectious disease, Cryptococcus neoformans infectious disease, plaster Microsporum infectious disease, Trichophyton rubrum infectious disease, Aspergillus fumigatus infectious disease. [0003] In recent years, with the wide application of broad-spectrum antibiotics, corticosteroids and imm...

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Problems solved by technology

[0004] At present, the nitrogen azole compounds that have been reported and are commonly used in clinical practice include Ketoconazole (KCZ), Fluconazole (Fluconazole, FCZ), Vitaconazole ( Voriconazole, VCZ), itraconazole (Itraconazole, ICZ), amphotericin B (Amphotericin B, AMB), etc., but these compounds still have the above-mentioned defects such as large toxic and side effects, narrow antibacterial spectrum, and easy to develop drug resistance, such as The dose required to exert the drug effect is relatively large, so it will cause relatively large toxic and side effects to the human body

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