Application of perilipin in preparation of medicine

Abstract

The invention belongs to the field of preparation of medicines and particularly relates to an application of perilipin in preparation of a medicine for inhibiting fat cell autophagy and treating lipid metabolism disorder. According to the study, berberine and Perilipin with inhibiting action on the fat cell autophagy are used for detection and a result shows that the autophagy promotes degradation of Perilipin; an autophagy agonist ABT737 is adopted for observing the degradation of the Perilipin, and after autophagy is activated by ABT737, the expression of the Perilipin is obviously reduced; and after treatment of the berberine, compared with the individual ABT737 group, a common treatment group of the berberine and the ABT737 has the advantage that the expression of the Perilipin is increased. in conclusion, the Perilipin has an inhibiting action on the fat cell autophagy, the reduction of the content of the Perilipin promotes lipolysis and causes disorder of energy metabolism of the whole organism; therefore, a new research direction is provided for treating the lipid metabolism disorder.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and particularly relates to the application of perilipid droplet protein in the preparation of drugs for inhibiting fat cell autophagy and drugs for treating lipid metabolism disorders. Background technique [0002] The structure of intracellular lipid droplets consists of triglycerides and a small amount of cholesteryl esters to form the core of neutral lipid droplets, which are covered with a single layer of phospholipids. At the same time, a large number of proteins are located on the surface of the single layer of phospholipids of lipid droplets, called lipid droplet surface proteins. . For adipocytes, lipid droplets are the most important part of their cells. A typical adipocyte isolated from white adipose tissue contains a large lipid droplet with a diameter of more than 100 μm, occupying most of the space in the cell, called Unilocular lipid droplets; adipocytes isolated from brown adi...

AI Technical Summary

Problems solved by technology

[0005] There are few studies on the relationship between Perilipin expression and human obesity, and the results are not completely consistent due to many factors such as different body mass index spans of the research subjects, small sample size, and different adipose tissue locations.

However, there have been no reports on the correlation between Perilipin and autophagy

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