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Traditional Chinese medicine compound cancer-attacking liposomal preparation for treating lung cancer and preparation method thereof

A liposome preparation and liposome technology, applied in the field of traditional Chinese medicine, can solve the problems of unsatisfactory curative effect, large toxic and side effects, low cancer curative effect, etc., and achieve the effect of improving the clinical curative effect of anti-cancer

Inactive Publication Date: 2013-12-04
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapeutic drugs have a certain effect on cancer, but they have severe side effects

Method used

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  • Traditional Chinese medicine compound cancer-attacking liposomal preparation for treating lung cancer and preparation method thereof
  • Traditional Chinese medicine compound cancer-attacking liposomal preparation for treating lung cancer and preparation method thereof
  • Traditional Chinese medicine compound cancer-attacking liposomal preparation for treating lung cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: A kind of liposome preparation and its preparation method of Chinese medicine compound anti-tumor component liposome for the treatment of lung cancer, and the preparation method steps are as follows:

[0027] (1) The weight of the anti-cancer components of the Chinese medicine compound is: paclitaxel 18mg, bufalin 18mg.

[0028] (2) The ratio of raw materials for liposome preparation is 900 mg of lecithin, 90 mg of amphiphilic polyethylene glycol 2000-distearoylphosphatidylethanolamine, and 90 mg of cholesterol;

[0029] (3) The liposome preparation method is prepared by ethanol injection method. Precisely measure 90mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, and preheat it in a constant temperature water bath at 50°C for 35min;

[0030] (4) Take the liposome raw material proportioned in step 2 into a beaker, add 36 mg of the Chinese medicine compound anti-cancer drug component in step 1, and then add an appropriate amount of absolu...

Embodiment 2

[0032] Embodiment 2: A liposome preparation of Chinese medicine compound anti-tumor component for treating lung cancer and its preparation method, and the steps of the preparation method are as follows:

[0033] (1) The weight of the anti-cancer components of the Chinese medicine compound is: paclitaxel 8mg, bufalin 16mg.

[0034] (2) The ratio of raw materials for liposome preparation is 600 mg of lecithin, 60 mg of amphiphilic polyethylene glycol 2000-distearoylphosphatidylethanolamine, and 60 mg of cholesterol;

[0035] (3) The liposome preparation method is prepared by ethanol injection method. Precisely measure 90 mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, and preheat it in a constant temperature water bath at 55°C for 30 minutes;

[0036] (4) Take the liposome raw material proportioned in step 2 into a beaker, add 24 mg of the Chinese medicine compound anti-cancer drug component in step 1, and then add an appropriate amount of absolute ethanol to...

Embodiment 3

[0038] Example 3: A liposome preparation of Chinese medicine compound anti-tumor component for the treatment of lung cancer and its preparation method, and the steps of the preparation method are as follows:

[0039] (1) The weight of the anti-cancer components of the traditional Chinese medicine compound is: paclitaxel 24mg, bufalin 12mg.

[0040] (2) The ratio of raw materials for liposome preparation is 900 mg of lecithin, 90 mg of amphiphilic polyethylene glycol 2000-distearoylphosphatidylethanolamine, and 90 mg of cholesterol;

[0041] (3) The liposome preparation method is prepared by ethanol injection method. Precisely measure 90mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, and preheat it in a constant temperature water bath at 50°C for 35min;

[0042] (4) Take the liposome raw material proportioned in step 2 into a beaker, add 36 mg of the Chinese medicine compound anti-cancer drug component in step 1, and then add an appropriate amount of absolut...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine compound cancer-attacking liposomal preparation for treating lung cancer (non-small cell lung cancer and small cell lung cancer) and a preparation method thereof. The traditional Chinese medicine compound liposomal preparation is prepared by taxol and bufalin according to a certain proportion. The preparation method includes: using ethanol injection to prepare liposomal to prepare the preparation. Animal in vivo anticancer pharmacology experiments show that the preparation has evident inhibition effect on growing of lung cancer (non-small cell lung cancer and small cell lung cancer), and the anticancer activity of the preparation is evidently higher than the chemotherapeutic drug 5-fluorouracil. The anticancer effect of the traditional Chinese medicine compound cancer-attacking liposomal preparation is higher than that of traditional Chinese medicine compound cancer-attacking non-liposomal preparation.

Description

1. Technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a liposome preparation of Chinese medicine anti-cancer components for treating lung cancer (non-small cell lung cancer and small cell lung cancer) and a preparation method thereof. 2. Background technology [0002] Cancer is a formidable enemy that endangers human health. There are about 1.6 million new cases of cancer in my country every year, and about 1.3 million people die of cancer every year. The number of deaths from cancer in the country is increasing year by year. my country is a high-incidence area for lung cancer, lung cancer and other cancers, and the cancer mortality rate remains high. . [0003] There are currently no effective drugs that cure most cancer patients. Although chemotherapeutic drugs have certain curative effects on cancer, they have severe side effects, and Chinese patent medicines generally have low curative effects on cancer,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61K9/127A61P35/00A61K31/337
Inventor 章永红章迅
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE