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Preparation method of compound paracetamol and amantadine hydrochloride capsule

A technology of compound acetaminophen and capsules, which is applied in capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can solve the problems of many operation steps, high production costs, and large content fluctuations, and achieve fewer operation steps , low drying temperature and low related substances

Active Publication Date: 2013-12-25
HAINAN ASIA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The disclosed preparation method still has the problem of uneven mixing of main ingredients and auxiliary materials in the granulation process, resulting in uneven content of chlorpheniramine maleate in the finished product, large fluctuations in content, and unstable product quality; in addition, the process temperature is high, Cause paracetamol to decompose to produce toxic para-aminophenol, the content of related substances is high; the operation steps are many, cumbersome, and the production cost is high, which is not conducive to industrialized large-scale production

Method used

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  • Preparation method of compound paracetamol and amantadine hydrochloride capsule
  • Preparation method of compound paracetamol and amantadine hydrochloride capsule
  • Preparation method of compound paracetamol and amantadine hydrochloride capsule

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Embodiment Construction

[0038] In order to enable those skilled in the art to better understand the present invention, specific examples are given below to describe in detail.

[0039] A kind of preparation method of compound fenfenthane capsule, comprises the steps:

[0040] First mix dextrin, artificial bezoar, chlorpheniramine maleate and caffeine (according to 2 parts by weight of chlorpheniramine maleate, 10 parts by weight of artificial bezoar, 15 parts by weight of caffeine and auxiliary materials) to obtain a mixed powder Ⅰ; then mix amantadine hydrochloride, acetaminophen (according to 100 parts by weight of amantadine hydrochloride, 250 parts by weight of acetaminophen) and mixed powder I to obtain mixed powder II; then, add mixed powder II The wetting agent is made into a soft material, and after sieving and granulating, it is added to a pill-making pot and rolled into a mother pellet; finally, the mother pellet is taken to make a pellet, and the powder is rolled and wrapped, and a lubrica...

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Abstract

The invention relates to the technical field of the pharmacy, and especially relates to a preparation method of a compound paracetamol and amantadine hydrochloride capsule. The method is characterized in that smaller amounts of components comprising dextrin, calculus bovis factitious, chlorphenamine maleate and caffeine in a prescription are uniformly mixed to obtain mixed powder I, and larger amounts of compounds comprising viregyt hydrochloride and paracetamol in the prescription are uniformly mixed with the mixed powder I to realize uniform mixing and the uniformity of the content of the chlorphenamine maleate in the whole capsule. Double-tapered rotary vacuum drying is adopted, the physical and chemical properties of a material are not changed after the drying of the material, and the content of relevant substances in a finally finished product is low.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of compound anfenamide capsules. Background technique [0002] More than 90% of colds are caused by viruses. If you want to cure colds quickly, fighting against viruses is the fundamental treatment. It takes about a week for most cold viruses to infect the host cells before cold symptoms erupt. The introduction of the antiviral drug amantadine into cold medicine can successfully prevent and treat influenza, breaking the current situation that it takes a week for a cold to take medicine or not. The antiviral mechanism of amantadine is: when the virus has not entered the cell, amantadine can effectively prevent the virus from uncoating and prevent its entry; if the virus has entered the cell, amantadine can hinder the replication of the genetic factors of the virus. Taking cold medicine containing amantadine within 36 hours of the initial stage of a cold can...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/48A61P31/16A61P11/00A61P29/00A61K31/522A61K31/4402A61K31/13A61K31/167
Inventor 游水英
Owner HAINAN ASIA PHARM CO LTD
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