Magnetic heterocyclic amine molecularly imprinted polymer and preparation method thereof

A technology of molecular imprinting and heterocyclic amines, applied in the field of new material research, can solve the problems of complex substrates, cumbersome operations, and long time-consuming meat products

Inactive Publication Date: 2013-12-25
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The sample pretreatment process of traditional meat products is cumbersome and time-consuming, and the substrate of meat products is complex and the content of heterocyclic amine samples is low. The traditional method is difficult to detect heterocyclic amines.

Method used

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  • Magnetic heterocyclic amine molecularly imprinted polymer and preparation method thereof
  • Magnetic heterocyclic amine molecularly imprinted polymer and preparation method thereof
  • Magnetic heterocyclic amine molecularly imprinted polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Co-precipitation method to prepare magnetic particles: weigh 1.2986g (about 8mmol) FeSO 4 ·7H 2 O, 1.1121g (about 4mmol) FeCl 3 , dissolved in 30mL ultrapure water, and the solution was mixed and placed in a three-necked bottle. Stir at high speed under the condition of 400r / min, and feed nitrogen gas for one hour at the same time. Then slowly add 8 mL of 5 mol / L NaOH dropwise, and black particles can be seen. Stirring was continued for 1 hour, then the temperature was raised to 90° C., and the temperature was kept stirring for 1 hour. After the reaction is completed, the obtained black particles are repeatedly cleaned with ultrapure water, dispersed in ultrapure water, and sealed for future use. Collected with a magnet, it can be seen that the particles have strong magnetic properties.

[0049]Preparation of magnetic molecularly imprinted polymers by precipitation polymerization: Pipette 3.0 mL of the above-synthesized Fe 3 o 4 Add magnetic particles (about 0.32...

Embodiment 2

[0052] In order to observe the morphology of magnetic molecularly imprinted polymers, the synthetic Fe 3 o 4 , magnetic non-molecularly imprinted polymer (NIP, the synthesis process is the same as the preparation of magnetic molecularly imprinted polymer except that the template molecule Nor-Harman is not added), and magnetic molecularly imprinted polymer (MIP) were characterized by scanning electron microscopy. Depend on figure 1 a It can be seen that Fe 3 o 4 It is a spherical particle with a particle size of about 30-40nm. Due to the anisotropic dipole attraction, the obtained Fe 3 o 4 Nanoparticles tend to aggregate to form clusters. figure 1 In b and 1c, NIP and MIP are also spherical particles with a particle size of about 50-60nm, which indicates that the polymer is successfully wrapped in Fe 3 o 4 On the nucleus, the formation of Fe 3 o 4 Core-shell structure of MAA. figure 1 d is the MIP after 30min ultrasonic extraction, and figure 1 c comparison, it is fo...

Embodiment 3

[0054] In order to investigate the recognition of magnetic molecularly imprinted polymers, Harman, a heterocyclic amine similar to Nor-Harman's molecular structure, was selected as a reference compound in the experiment. Take 1.5 mg of Nor-Harman as the template molecule MIP to carry out dispersion extraction experiments on 100 μg / L of Nor-Harman and Harman, and use the percentage of the amount of the substance to be tested extracted by the polymer to the total amount of the initial substance as the extraction efficiency, The comparison result is as figure 2 As shown, magnetic molecularly imprinted polymers have better extraction selectivity for template molecules Nor-Harman, mainly due to the fact that the surface of molecularly imprinted polymers has "cavities" with the same template molecule binding sites and the same shape and size, so the magnetic Molecularly imprinted polymers are more suitable for the extraction of heterocyclic amines in complex samples.

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Abstract

The invention discloses a magnetic heterocyclic amine molecularly imprinted polymer and a preparation method thereof. The magnetic heterocyclic amine molecularly imprinted polymer which takes heterocyclic amine as a template molecule and methacrylic acid (MAA) as a functional monomer is prepared by the method; the characteristics of the molecularly imprinted polymer are fully combined with those of the magnetic material; the magnetic heterocyclic amine molecularly imprinted polymer has the advantages of high selectivity, large adsorption capacity, rapid separation speed, high anti-interference capability and the like, and is suitable for analyzing heterocyclic amine in food and environment.

Description

technical field [0001] The invention relates to a preparation method of a magnetic heterocyclic amine molecular imprinting material, which belongs to the field of new material research. Background technique [0002] Molecular imprinting technology is a technology that uses artificial methods to prepare polymers with specific binding effects on specific molecules from the perspective of bionics. It has the advantages of specific selectivity, strong anti-interference, simple preparation, good stability, and long service life. Therefore, It has broad development prospects in chromatographic stationary phase, solid phase extraction, membrane separation, immunoassay, antibody simulation, chemical sensor, catalyst and synthetic enzyme. [0003] Magnetic material is a good separation material for sample pretreatment. It can not only use its superparamagnetism to separate from the medium under the action of an external magnetic field, but also endow its surface with a variety of rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/20C08F220/06C08F212/36C08J9/26C08K3/22B01J20/26B01J20/28B01J20/30
Inventor 王翊如邓卓陈曦
Owner XIAMEN UNIV
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