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A kind of preparation method of levofloxacin hydrochloride sodium chloride injection

A technology of levofloxacin hydrochloride and sodium chloride injection, applied in the field of medicine, can solve the problems of poor clinical use effect and safety, poor clarity, poor stability, etc., achieve good clarity, lighten the color, and ensure effectiveness Effect

Inactive Publication Date: 2015-09-16
HAINAN HOTMED TIANYA PHARMA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The present invention proposes a preparation method of levofloxacin hydrochloride sodium chloride injection, which solves the problem of dark color, poor clarity, many particles, poor stability, clinical use effect and safety of levofloxacin hydrochloride sodium chloride injection in the prior art Poor and other issues

Method used

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  • A kind of preparation method of levofloxacin hydrochloride sodium chloride injection
  • A kind of preparation method of levofloxacin hydrochloride sodium chloride injection

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Embodiment Construction

[0027] For a better understanding of the present invention, the present invention will be further specifically described below through the following examples, but it should not be construed as a limitation of the present invention. For some non-essential improvements and adjustments made by those skilled in the art according to the above-mentioned content of the invention, It is also considered to fall within the protection scope of the present invention.

[0028] According to the method disclosed in the present invention, the inventor performs the following operations:

[0029] (1) Take sodium chloride according to the prescription amount, add water for injection and stir to dissolve, and control the water temperature at 55-75°C;

[0030] (2) Take levofloxacin hydrochloride pre-dissolved according to the prescription amount and add it to the sodium chloride solution, and add water for injection to 30% of the total volume of the preparation. In this embodiment, the total volum...

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Abstract

The invention provides a method for preparing levofloxacin hydrochloride sodium chloride injection. By researching a liquid medicine preparation method, medicinal charcoal pretreatment and a terminal sterilization process, product quality is ensured by the aid of technologies of a concentrated solution and diluted solution method, charcoal slurry preparation from medicinal charcoal, water bath sterilization and the like, production is facilitated, obtained finished products have higher stability, so that the storage life of the finished products can be prolonged, and clinical use effects are better.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a preparation method of levofloxacin hydrochloride sodium chloride injection. Background technique [0002] Levofloxacin Hydrochloride Sodium Chloride Injection is a commonly used injection, which is often used in orthopedics, breast surgery, gastroenterology, infectious diseases, dermatology, etc. [0003] The traditional method for preparing levofloxacin hydrochloride sodium chloride injection, due to technical defects, such as when it prepares injections, usually weighs all the raw materials, then adds them to the feeding tank, stirs and dissolves, due to the solubility of different raw and auxiliary materials Different, ingredients with poor solubility cannot be completely dissolved, resulting in insufficient content of active ingredients, which affects the effectiveness of the product. In addition, the conventional method of using medicinal charcoal is to add it directly to the liqu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/00A61K9/08A61K31/5383A61P31/04
Inventor 黄循明覃俊杰
Owner HAINAN HOTMED TIANYA PHARMA
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