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Preparation method of Chinese materia medica preparation for treating senile dementia

A technology for senile dementia and traditional Chinese medicine preparations, which can be applied in the direction of medical formulas, drug combinations, and medical preparations containing active ingredients, etc., and can solve the problems that none of them has a certain curative effect

Inactive Publication Date: 2014-01-01
QINGDAO ZHONGREN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The research on senile dementia at home and abroad has received extensive attention, but for the degeneration and degeneration of brain nerve cells, memory loss and gradual dementia, at present, only symptomatic treatment is available. Although many drugs have been used, none of them have achieved a positive effect

Method used

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  • Preparation method of Chinese materia medica preparation for treating senile dementia

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Experimental program
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Effect test

Embodiment 1

[0013] According to the formula ratio of the preparation of the present invention, each component was weighed: 190g ginseng, 560g Zhishouwu, 275g epimedium, 450g medlar, 375g Anemarrhena, 450g rehmannia, 375g astragalus, and 275g kudzu root.

[0014] The preparation method is as follows: soak the ginseng, shouwu, epimedium, medlar, anemarrhena, raw land, astragalus and kudzu root weighed according to the above weight ratio in cold water for 2 hours, then add water to decoct for 3 times, and the first Add 5 times the weight of Chinese medicine in the first decoction, boil on high heat first, keep boiling on warm fire for 1 hour, filter, and use the decoction for later use; filter residue is used for the second decoction, add 4 times the weight of Chinese medicine in the second decoction Measure the water, first boil on high heat, keep boiling on low heat for 1 hour, filter, and decoct for later use; filter residue is used for the third decoction, add 4 times the amount of water ...

Embodiment 2

[0015] Embodiment 2, the acute toxicity test of traditional Chinese medicine preparation for treating senile dementia to mice

[0016] Select 50 pure Kunming mice aged 6-8 weeks and weighing 18-22g, half male and half male, randomly divided into 5 groups, 10 mice in each group, and the experimental doses are 2.5, 4.4, 7.9, 14, 25g / kg five doses were tested.

[0017] Experimental result proves that the LD of the Chinese medicine preparation for the treatment of senile dementia of the present invention 50 >25g / kg, no obvious toxicity. In order to observe the maximum tolerated dose of the mice, 100g / kg was administered accumulatively in 24 hours, which is equivalent to 27.6 times of clinical medication. Animals were observed for one week, and no death or adverse reactions were seen.

Embodiment 3

[0018] Embodiment 3, the influence of the traditional Chinese medicine preparation for treating senile dementia of the present invention on M1, M3 receptor gene expression in the brain of dementia rat model

[0019] Prepare the animal model of senile dementia: choose 22-month-old rats, use kainic acid to destroy the brain basal nucleus, selectively destroy neurons, prepare the dementia model of aged rats with learning and memory dysfunction, and measure the production by the water maze method. The time required for the experimental animals to come to the stage after the modeling was significantly longer than that before the modeling, p<0.05. After modeling, the experimental animals showed learning and memory dysfunction, indicating that the modeling was successful.

[0020] The effect of the traditional Chinese medicine preparation for treating senile dementia of the present invention on the expression of M1 and M3 receptor genes in dementia model rats is observed by reverse t...

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Abstract

The invention relates to a preparation method of a Chinese materia medica preparation for treating senile dementia. A formula of the Chinese materia medica preparation comprises, by weight, 6.4% of ginseng, 19.0% of prepared fleece flower roots, 9.3% of herba epimedii, 15.3% of the fruit of Chinese wolfberry, 12.7% of rhizoma anemarrhenae, 15.3% of the root of rehmannia, 12.7% of astragalus membranaceus and 9.3% of the root of kudzu vine. The components are weighed according to proportions, the components are soaked in cold water for two hours, then water is added to conduct decoction for three times, decocted liquor of three times of decoction is mixed, then decoction on the decocted liquor is carried out for 20-30 minutes through warm fire, and the Chinese materia medica preparation for treating the senile dementia is obtained. The Chinese materia medica preparation prepared through the method has the effects of reducing blood fat, preventing and treating arteriosclerosis, scavenging free radicals, improving and delaying brain aging, expanding the blood vessel of the brain, increasing cerebral blood flow and motivating and improving brain intelligence, and is an ideal medicine for treating the senile dementia.

Description

Technical field: [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation for treating senile dementia, belonging to the technical field of traditional Chinese medicine preparations. Background technique: [0002] Alzheimer's disease is a kind of brain degenerative disease with widely distributed senile plaques in the cerebral cortex and global brain atrophy as the main pathological changes, and with progressive dementia as the main clinical feature. , Mental decline, dizziness and tinnitus, laziness and sleepiness, hypothermia in the limbs, weak bones or numbness in the limbs, muscle fatigue, pale or fat tongue or petechiae, thin white or slippery tongue coating, deep thready pulse Lord. [0003] Research on senile dementia at home and abroad has been widely valued, but for the degeneration and degeneration of brain nerve cells, memory loss and gradual dementia, at present, only symptomatic treatment is available. Although many dru...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P25/28
Inventor 岳启安张述智
Owner QINGDAO ZHONGREN PHARMA
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