Compound ivermectin albendazole transdermal agent for livestock and application method thereof

A technology of albendazole transdermal agent and ivermectin, which is applied in the field of preparation of veterinary pharmaceuticals, can solve the problems affecting the treatment effect of animal diseases, the development of transdermal agents, and the impact of treatment effect, etc. The effect of low irritative reaction, convenient treatment method and easy operation

Active Publication Date: 2014-01-08
河南亚卫动物药业有限公司
View PDF2 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used dosage form of albendazole is tablet, which has poor palatability and relatively low bioavailability, which affects the therapeutic effect of animal diseases
Combining the respective advantages of ivermectin and albendazole in the treatment and prevention of parasitic diseases, it is of great significance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The content of each component in the veterinary compound ivermectin albendazole transdermal agent product provided by the present embodiment is as follows:

[0023] Ivermectin, 0.5% (w / v); Albendazole, 5% (w / v);

[0024] Solubilizer: Tween-80, 0.5% (v / v);

[0025] Penetration enhancer: laurocaprazine, 3% (v / v);

[0026] Diluent: N-methyl-pyrrolidone, 15% (v / v); 95% ethanol, 20% (v / v); propylene glycol to 100% (v / v).

[0027] The preparation of the veterinary compound ivermectin albendazole transdermal agent of the present embodiment mainly comprises the following steps:

[0028] (1) Take an appropriate amount of propylene glycol, heat it to 50-60°C, add the prescribed amount of ivermectin, stir to dissolve, and set aside;

[0029] (2) Take the prescribed amount of N-methyl-pyrrolidone, add the prescribed amount of albendazole, stir to dissolve, and set aside;

[0030] (3) Mix the two solutions of (1) and (2), add the prescribed amount of 95% ethanol and Tween-80, st...

Embodiment 2

[0034] The content of each component in the veterinary compound ivermectin albendazole transdermal agent product provided by the present embodiment is as follows:

[0035] Ivermectin, 1% (w / v); Albendazole, 10% (w / v);

[0036] Solubilizer: Tween-80, 1.5% (v / v);

[0037] Penetration enhancer: laurocaprazine, 5% (v / v);

[0038] Diluent: N-methyl-pyrrolidone, 20% (v / v); 95% ethanol, 20% (v / v); propylene glycol, 100% (v / v).

[0039] The preparation method of the veterinary compound ivermectin albendazole transdermal agent of this embodiment is similar to the preparation method of the veterinary compound ivermectin albendazole transdermal agent of Example 1, and will not be described again. But its preparation principle and main steps are as follows:

[0040] (1) Take an appropriate amount of diluent, such as propylene glycol, add the prescribed amount of ivermectin, stir to dissolve under appropriate conditions, and set aside;

[0041] (2) Take the prescribed amount of albenda...

Embodiment 3

[0048]For further illustrating the product effect of provided veterinary compound ivermectin albendazole transdermal agent of the present invention, the inventor takes Example 2 The veterinary compound ivermectin albendazole transdermal product provided was taken as an example, and further comparative experiments were carried out on its efficacy. The experiment is as follows:

[0049] The comparative medicines for drug efficacy test are as follows:

[0050] Ivermectin injection, Zhejiang Hisun Pharmaceutical Co., Ltd., production batch number is 20121211, specification is 10ml / bottle, each contains ivermectin 0.5g;

[0051] Albendazole tablets, Henan Yawei Animal Pharmaceutical Co., Ltd., the production batch number is 20120324-1, and the specification is 200mg / tablet g;

[0052] Ivermectin albendazole powder, Henan Yawei Animal Pharmaceutical Co., Ltd., the production batch number is 20120311-1, the specification is 100g / package, each contains 10g of ivermectin and 0.2g of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of preparation of medicament for livestock, and particularly relates to a compound ivermectin albendazole transdermal agent for livestock and an application method thereof. The transdermal agent is a mixture of two or three components below at any proportion: ivermectin, albendazole, solubilizer tween-80, a laurocapram transdermal accelerant, a 95% ethanol diluent, an N-methyl-pyrrolidone and propylene glycol. When the transdermal agent is used for treating parasitic diseases of animals such as pigs and sheep, the transdermal agent is flow-coated from the head part to the tail root part along a dorsal line after hairs at the back part are uniformly pushed aside towards two sides, and good treatment effect can be obtained after the transdermal agent is used continuously for three days. The preparation method of the compound ivermectin albendazole transdermal agent for livestock is simple; in comparison with other dosage form in the prior art, the medicine use way is simpler and more convenient, and more dosage is saved; as no liver first-pass effect exists, influence from gastric emptying rate and the like is avoided, the irritability reaction degree of the animals is low, the treatment effect is better, the treatment way is convenient and fast, and the operation is easy.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary medicaments, in particular to a veterinary compound ivermectin albendazole transdermal agent and its usage. Background technique [0002] In the process of livestock and poultry breeding, there are many types of pathogens and wide distribution of parasites, which have a great impact on the livestock and poultry breeding industry. All kinds of parasites often endanger the health of animals in a hidden way, causing various chronic and wasting diseases of livestock and poultry, which not only affect the growth and development of livestock and poultry, reduce the quality and quantity of livestock and poultry products, but also cause a large number of livestock and poultry Death brings serious economic losses to the breeding industry, and some parasitic diseases also pose a serious threat to people's health. Among the parasitic diseases of livestock and poultry, nematodes and extern...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/7048A61K9/10A61P33/00A61K31/4184
Inventor 刘钊锋邵艳华郭芳茹张遂平王菊萍牛咏梅王黎明
Owner 河南亚卫动物药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap