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Method for preparing losartan potassium and hydrochlorothiazide composition

A technology for losartan potassium hydrochlorothiazide and losartan potassium is applied in the field of preparation of pharmaceutical preparations for treating hypertension, and can solve the problems of curative effect and safety risks, instability of hydrochlorothiazide, quality reduction of hydrochlorothiazide tablets, etc.

Active Publication Date: 2014-01-15
BEIJING WINSUNNY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, losartan potassium and hydrochlorothiazide are granulated separately, and then mixed and compressed into tablets, which reduces the chance of contacting hydrochlorothiazide with losartan potassium and other auxiliary materials. Unstable properties, under the action of water media, it is more likely to react, thereby reducing the quality of Losartan Potassium Hydrochlorothiazide Tablets, bringing risks to the efficacy and safety of patients' medication

Method used

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  • Method for preparing losartan potassium and hydrochlorothiazide composition
  • Method for preparing losartan potassium and hydrochlorothiazide composition
  • Method for preparing losartan potassium and hydrochlorothiazide composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Mix 50 g of losartan potassium, 80 g of microcrystalline cellulose, 20 g of lactose, and 5 g of croscarmellose sodium, and dry granulate to obtain drug granules a containing losartan potassium;

[0034] (2) Mix 12.5g hydrochlorothiazide, 70g pregelatinized starch, 40g microcrystalline cellulose, 3g povidone, and 3g carboxymethyl starch sodium, and dry granulate to obtain drug granules b containing hydrochlorothiazide;

[0035] (3) Dissolve an appropriate amount of polymethacrylate in water to make a coating solution;

[0036] (4) Put the drug granule b in the coating machine, and spray the coating solution when the temperature in the coating machine reaches 40-45°C,

[0037] Screen 20-40 mesh particles, that is, coated particles c;

[0038] (5) Mix drug granules a and coating granules c evenly, add magnesium stearate, compress into tablets or pack into capsules.

Embodiment 2

[0040]

[0041] Preparation method is the same as embodiment 1

Embodiment 3

[0043]

[0044] Preparation method is the same as embodiment 1

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Abstract

The invention discloses a method for preparing a losartan potassium and hydrochlorothiazide composition. The method comprises the following steps: respectively carrying out dry granulation of losartan potassium and hydrochlorothiazide, coating above dry-granulated hydrochlorothiazide, uniformly mixing above obtained losartan potassium particles with the above coated hydrochlorothiazide particles, and tabletting or filling into capsules. The method can effectively control the content of relevant substances, guarantees the content uniformity of main drugs, reduces untoward effects, and realizes a good pressure reducing effect.

Description

field of invention [0001] The invention relates to a preparation method of a drug preparation for treating hypertension, in particular to a preparation method of a losartan potassium hydrochlorothiazide composition. Background technique [0002] Hypertension is a chronic disease characterized by continuous elevation of arterial blood pressure, which often causes lesions in heart, brain, kidney and other important organs with corresponding consequences. The treatment of hypertension requires long-term medication. Generally, it starts with a small dose and gradually increases the dose. There are generally three countermeasures for patients whose blood pressure cannot be controlled after receiving a drug treatment. One is to increase the dose of the original drug, but there will be It may lead to the consequence that the antihypertensive effect is not enhanced and the adverse reactions increase; the second is to switch to another drug, but if the effect after changing the drug ...

Claims

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Application Information

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IPC IPC(8): A61K31/549A61K9/20A61K9/48A61K9/16A61P9/12A61K31/4178
Inventor 耿玉先产运霞
Owner BEIJING WINSUNNY PHARMA CO LTD
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