Preparation method of holothuria nobilis and application thereof in treatment of diabetes mellitus

An anti-diabetic and black ginseng technology is applied in the application field of treating diabetes, can solve problems such as no reports of black ginseng, and achieve the effects of regulating blood lipids, improving glucose tolerance, protecting and repairing damaged islets

Inactive Publication Date: 2014-01-29
郑毅男 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] After searching, there is no report on black ginseng's anti-type 1 and type 2 diabetes animal experiments

Method used

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  • Preparation method of holothuria nobilis and application thereof in treatment of diabetes mellitus
  • Preparation method of holothuria nobilis and application thereof in treatment of diabetes mellitus
  • Preparation method of holothuria nobilis and application thereof in treatment of diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The preparation method of embodiment 1 black ginseng: Take fresh ginseng, wash it, remove sundries, put it in a drying oven for 8 hours at 60°C, steam it in high-temperature steam for 2 hours at 115°C, and dry it at 60-70°C for 8 hours after steaming, take it out and dry it until the water content is 15 % below, that is, black ginseng 1. The total saponins were determined and analyzed by HPLC 21.06±0.98 mg / g, of which the rare saponins Rg 3 , Compound K and Rg 5 0.52±0.01, 0,35±0.01 and 2.72±0.02 (mg / g), respectively.

Embodiment 2

[0077] The preparation method of embodiment 2 black ginseng: Take fresh ginseng, wash it, remove sundries, put it in a drying oven to dry at 60°C for 8 hours, steam at 115°C for 2 hours in high-temperature steam after drying, and dry at 60-70°C for 8 hours after steaming, repeat this twice, that is Get black ginseng 2. The total saponins were determined and analyzed by HPLC 50.28±1.29 mg / g, of which the rare saponins Rg 3 , Compound K and Rg 5 They were 3.52±0.03, 3.61±0.03 and 27.51±0.12 (mg / g), respectively.

Embodiment 3

[0078] The preparation method of embodiment 3 black ginseng: Take the fresh ginseng, wash it, remove the sundries, put it in a drying oven to dry at 60°C for 8 hours, steam it in high-temperature steam for 2 hours at 115°C after drying, and then dry it at 60-70°C for 8 hours, repeat this process 3 times, that is Get black ginseng3. The total saponins were determined and analyzed by HPLC 65.50±1.69 mg / g, of which the rare saponins Rg 3 , Compound K and Rg 5 They were 5.42±0.04, 5.61±0.04 and 65.51±1.65 (mg / g), respectively.

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Abstract

The invention provides a method for preparing holothuria nobilis from fresh ginseng, an effect of the holothuria nobilis on diabetes mellitus, and application of the holothuria nobilis in a drug for treating the diabetes mellitus. The holothuria nobilis is characterized by being prepared from the fresh ginseng by steps of repeatedly steaming by high-temperature steam for 2-9 times and drying. A diabetes mellitus animal model proves that the holothuria nobilis has the effects of reducing blood sugar level, improving glucose tolerance, regulating blood fat, protecting and repairing damaged islet after administration treatment of the holothuria nobilis. The substance can be applied to prevention and treatment of the diabetes mellitus.

Description

technical field [0001] The invention relates to a processing method of black ginseng, a processed product of fresh ginseng, and its application in treating diabetes. [0002] Background technique [0003] Diabetes and its complications are one of the major diseases that threaten human health. The mortality rate is second only to tumors and cardiovascular diseases, and currently ranks third among various diseases. Diabetes is mainly divided into type 1 and type 2 diabetes, and type 2 diabetes accounts for about 90%. In recent years, the number of diabetic patients in the world has been increasing rapidly at an alarming rate. In 2010, the Diabetes Branch of the Chinese Medical Association conducted a survey on the prevalence of diabetes in my country, which showed that the prevalence of diabetes in men and women over the age of 20 in my country reached 10.6% and 8.8%, respectively, and the overall prevalence reached 9.7%. According to the calculation results obtained from th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P3/06A61P3/10
Inventor 郑毅男马东升李永娟李伟董蕊李慧萍
Owner 郑毅男
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