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Application of a traditional Chinese medicine composition in preparation of medicine for treating vascular dementia

A technology for vascular dementia and composition, which is applied in the application field of traditional Chinese medicine composition in the preparation of drugs for treating vascular dementia, and can solve problems such as side effects, high price, and unsatisfactory curative effect

Active Publication Date: 2015-08-12
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs are usually accompanied by certain side effects when treating vascular dementia, and at the same time, some of them have unsatisfactory curative effects or high prices

Method used

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  • Application of a traditional Chinese medicine composition in preparation of medicine for treating vascular dementia
  • Application of a traditional Chinese medicine composition in preparation of medicine for treating vascular dementia
  • Application of a traditional Chinese medicine composition in preparation of medicine for treating vascular dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] 【prescription】

[0165]

[0166] 【Method】

[0167] For the above 15 raw materials, safflower is crushed into fine powder and sieved; Uncaria is crushed into coarse powder, impregnated twice with 75% ethanol for 24 hours each time, filtered, and the filtrate is recovered with ethanol, concentrated into a thick paste, 70°C Dry under reduced pressure and crush into fine powder; decoct the medicinal dregs and the rest of the thirteen flavors of Radix Paeoniae Alba, add water for two times, each time for 2 hours, collect the distilled volatile oil at the same time, filter the decoction, and concentrate the filtrate into a thick paste. Dried and pulverized into fine powder; the volatile oil was clathrated with 7 times the amount of β-cyclodextrin, mixed evenly with the above-mentioned dry cream powder and safflower fine powder, added 24g of sodium carboxymethyl starch and 8g of microcrystalline cellulose to make a pill, Dry and pack. 5g per bag, that is.

Embodiment 2

[0169] 【prescription】

[0170]

[0171] 【Method】

[0172] For the above 15 raw materials, safflower is crushed into fine powder and sieved; Uncaria is crushed into coarse powder, impregnated twice with 75% ethanol for 24 hours each time, filtered, and the filtrate is recovered with ethanol, concentrated into a thick paste, 70°C Dry under reduced pressure and crush into fine powder; decoct the medicinal dregs and the rest of the thirteen flavors of Radix Paeoniae Alba, add water for two times, each time for 2 hours, collect the distilled volatile oil at the same time, filter the decoction, and concentrate the filtrate into a thick paste. Dried, crushed into fine powder; inclusion of volatile oil with 7 times the amount of β-cyclodextrin, mixed evenly with the above-mentioned dry cream powder and safflower fine powder, granulated with 90% ethanol, dried, and made into 1000 granules.

Embodiment 3

[0174] 【prescription】

[0175]

[0176] 【Method】

[0177] For the above 15 raw materials, safflower is crushed into fine powder and sieved; Uncaria is crushed into coarse powder, impregnated twice with 75% ethanol for 24 hours each time, filtered, and the filtrate is recovered with ethanol, concentrated into a thick paste, 70°C Dry under reduced pressure and crush into fine powder; decoct the medicinal dregs and the rest of the thirteen flavors of Radix Paeoniae Alba, add water for two times, each time for 2 hours, collect the distilled volatile oil at the same time, filter the decoction, and concentrate the filtrate into a thick paste. Dry and pulverize into fine powder; the volatile oil is clathrated with 7 times the amount of β-cyclodextrin, mixed evenly with the above-mentioned dry cream powder and safflower fine powder, added 2 g of sodium starch glycolate, granulated with 90% ethanol, dried, and Adjust the total amount of microcrystalline cellulose to 500g, and table...

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PUM

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Abstract

The invention discloses a new medicine application of a traditional Chinese medicinal composition in preparing a medicine for treating vascular dementia. The traditional Chinese medicinal composition consists of the following crude medicines: 170-510 parts of uncaria rhynchophylla, 150-450 parts of ligusticum wallichii, 80-240 parts of ephedra, 80-240 parts of asarum, 80-240 parts of radix aconiti lateralis preparata, 100-300 parts of white paeony root, 80-240 parts of notopterygium root, 50-150 parts of radix angelicae pubescentis, 80-240 parts of divaricate saposhnikovia root, 80-240 parts of rehmannia, 80-240 parts of angelica, 250-750 parts of suberect spatholobus stem, 100-300 parts of peach kernel, 100-300 parts of safflower and 80-240 parts of radix angelicae. The traditional Chinese medicinal composition has a good effect on treating chronic cerebral hypoperfusion vascular dementia, multiple cerebal infarction vascular dementia and subcortical ischemic vascular dementia, and is capable of improving learning and memory abilities as well as behavior capacities of patients.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to a new application of a traditional Chinese medicine composition in preparing medicine for treating vascular dementia. Background technique [0002] Vascular dementia refers to a severe cognitive impairment syndrome caused by cerebrovascular diseases. It can be caused by the lesions of these blood vessels themselves, or by the lesions of extracranial large vessels and the heart, which indirectly affects the blood vessels in the brain and is caused by insufficient blood supply. Ischemic and hypoxic changes in brain tissue eventually lead to a general decline in brain function. The etiology can be mainly divided into: multiple infarctions and reduced brain tissue volume caused by cerebral artery occlusion, ischemia and hypoxic hypoperfusion, subcortical white matter lesions, hemorrhagic lesions, and various types of inflammatory cerebrovascular disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P25/28A61P9/10
Inventor 谈英王勇胡利民代志陈红英翟付明高秀梅谭沛马鹏岗马舒冰
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA