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Preparation method of cefmenoxine hydrochloride dry powder

A technology of cefmenoxime hydrochloride and dry powder is applied in the field of preparation of dry drug powder, and can solve the problems of uneven mixing, large static electricity and difficult mixing, poor fluidity and the like

Inactive Publication Date: 2014-02-05
HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0027] If the specific volume of cefmenoxime hydrochloride prepared by the existing technology is between 3.0 and 4.0, the fluidity is poor, the static electricity is large and it is difficult to mix well, and the equipment requirements are high. It is necessary to have a static electricity removal device and mix for more than 3 hours before it can be mixed. , and some are not evenly mixed

Method used

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  • Preparation method of cefmenoxine hydrochloride dry powder

Examples

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Effect test

Embodiment 1

[0058] Add 4kg of cefmenoxime hydrochloride to 100L of water, adjust to dissolve with one or more aqueous solutions of sodium carbonate, sodium bicarbonate, and sodium hydroxide, add 0.1kg of activated carbon for decolorization for 15-30 minutes, filter aseptically, and enter In a crystallization tank in a sterile room, add XXX methanol to the filtrate as a dispersant, add dropwise 3M hydrochloric acid to pH 0.5-4.0, precipitate crystals, raise the temperature to 30-45°C, grow crystals for 1-30 minutes, and cool down to 15-29 ℃, grow crystals for 1-30 minutes, then lower the temperature to 0-14°C, grow crystals for 1-3 hours, filter, wash with 5L of water, and vacuum-dry at 35°C for 16 hours to obtain 3.2 kg of sterile cefmenoxime hydrochloride dry powder.

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Abstract

The invention relates to a preparation method of cefmenoxine hydrochloride dry powder. The method comprises the following steps: 1) adding cefmenoxine hydrochloride into water, adjusting by using water containing soda until the cefmenoxine hydrochloride is dissolved, adding active carbon for decoloring, and filtering; 2) adding methanol into a filtrate, adding acid to adjust the PH value to 0.5-4.0, and separating out crystal; 3) heating to 30-45 DEG C, growing the grain for 1-30 minutes, cooling to 15-29 DEG C, growing the grain for 1-30 minutes, cooling to 0-14 DEG C, growing the grain for 1-3 hours, filtering and drying, so as to obtain the cefmenoxine hydrochloride dry powder.

Description

Technical field: [0001] The present invention relates to a kind of preparation of medicine dry powder, particularly a kind of preparation method of cefmenoxime hydrochloride dry powder. Background technique: [0002] Cefmenoxime, the chemical structure is as follows: [0003] [0004] Also known as: thiaxime azole cephalosporins, Besterke, cefotaxime tetrazole and so on. It is a semi-synthetic third-generation cephalosporin. It is mainly used for infections of the respiratory system, hepatobiliary system, genitourinary system, and peritoneum caused by various sensitive bacteria. It can also be used for sepsis, burns, and postoperative infections. [0005] The existing preparations include: cefmenoxime hydrochloride for injection, the main components of which are cefmenoxime hydrochloride and anhydrous sodium carbonate. Its preparation method is usually by physically mixing cefmenoxime hydrochloride and anhydrous sodium carbonate. Therefore need to provide aseptic refin...

Claims

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Application Information

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IPC IPC(8): C07D501/22C07D501/36
CPCC07D501/12C07D501/36
Inventor 马杰王喜军张哲鸣
Owner HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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