Fixing apparatus for volume uniform radiation test of laboratory mice

A technology for fixing devices and experimental mice, which is applied in veterinary instruments, equipment for restraining animals, medical science, etc. It can solve the problem of unsatisfactory uniformity and flatness of the radiation dose received, and the impossibility of receiving the same radiation dose. Rats and other problems, to achieve the effect of easy promotion, simple operation and simple structure

Inactive Publication Date: 2014-02-26
徐州医学院附属淮海医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, utility model patent [Fan Saijun, Xu Jiaying, Qin Liqiang, etc. A fixture for rat irradiation experiments. CN201987699U, 2011.09.28. Xu Jiaying, Fan Saijun, Qin Liqiang, etc. A mouse used for radiation experiments Fixing device. CN201977959U, 2011.09.21.] Although multiple mice or rats can be placed side by side into the device for whole-body radiation of experimental animals, since the absorbed dose is inversely proportional to the square of the radiation distance, the distance between the experimental animals and the radiation The uniformity and flatness of the radiation dose received by the source are not ideal
Utility model patent [Liu Yong, Hu Weigang, Xu Qing. A medical mouse tumor irradiation fixation tube and fixation device. CN202283289U, 2012.06.27.] Although 12 mice were irradiated in batches, only the legs of the mice were irradiated. It is impossible for the mice to receive the same radiation dose as the local radiation on the head, and each mouse tube is arranged in a square shape.

Method used

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  • Fixing apparatus for volume uniform radiation test of laboratory mice
  • Fixing apparatus for volume uniform radiation test of laboratory mice
  • Fixing apparatus for volume uniform radiation test of laboratory mice

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Fixtures for Batch Uniform Radiation Experiments on Mice.

[0022] Such as Picture 1-1 , Figure 1-2 and Figure 1-3 The fixture shown is used for batch uniform radiation experiments on mice, including a cylindrical shell 1 with a closed bottom end and an open upper end; Cover plate 2; placed in the cylindrical shell 1 for accommodating experimental mice, twelve drop-shaped mouse-loading chambers 3 whose shape matches the shape of the experimental mouse; mouse-loading chambers 3 are all pointed to the center and rounded. It is radially arranged in a petal shape outwards, and the round end is tangent to the shell tube wall 4, and there is a through hole 5 through the shell tube wall 4 and the mouse cavity 3 at the lower part of each tangent line; the through hole 5 is large The tail of the mouse can pass through, which can not only cooperate with the positioning of the mouse, but also carry out experiments such as mouse tail vein injection and blood collect...

Embodiment 2

[0026] Example 2: Fixtures for uniform irradiation experiments in batches of rats.

[0027] Such as diagram 2-1 , Figure 2-2 and Figure 2-3 The fixture shown is used for batch uniform radiation experiments on rats, including a cylindrical shell 1 with a closed bottom end and an open upper end; Cover plate 2; placed in the cylindrical shell 1 for accommodating experimental mice, six drop-shaped mouse-loading chambers 3 whose shape matches the shape of the experimental mouse; the mouse-loading chambers 3 are all pointed to the center and rounded to the center. The outside is petal-shaped radially arranged, and the round end is tangent to the shell tube wall 4, and there is a through hole 5 passing through the shell tube wall 4 and the mouse cavity 3 at the bottom of each tangent line; the through hole 5 has a large capacity Pass the rat tail through. There are three threaded holes 6 evenly distributed on the upper end of the shell tube wall 4, and there are holes matched ...

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Abstract

The invention discloses a fixing apparatus for volume uniform radiation test of laboratory mice and belongs to fixing apparatus for animal experiments. The fixing apparatus comprises a cylindrical casing with the bottom end closed and the top end open, a circular cover plate capable of being connected fixedly in a detachable manner and capping the top opening of the cylindrical casing, and multiple water-drop-shaped chambers which are placed in the circular casing for containing the laboratory mice and in the shape fitting with shapes of the laboratory mice. The chambers are in radial arrangement with the centripetal tip ends and outwards round ends, the round ends are tangent with the wall of the casing, and through holes which are designed in size enabling tails of the mice to pass through and run through the wall of the casing and the walls of the chambers are formed below the tangent lines respectively. Multiple laboratory mice can be fixed completely at one time and then subjected to uniform radiation, so that consistency of experimental radiation dose is guaranteed while experiment efficiency is increased. The fixing apparatus is simple in structure, low in cost, convenient to operate and use and easy to produce and promote.

Description

technical field [0001] The invention relates to a radiation fixing device for animal experiments, in particular to a fixing device for uniform radiation experiments in batches of experimental mice. Background technique [0002] Today, due to the gradual application of nuclear technology in the fields of national defense and military, industrial and agricultural production, and medical life sciences, people have more and more opportunities to come into contact with radiation, and the chances of suffering radiation damage also increase accordingly. At the same time, malignant tumors are increasingly becoming the number one killer that threatens human health. With the development of science and technology, radiotherapy technology has also made great progress in recent decades. Therefore, whether it is research and development of anti-radiation drugs with high efficiency, low toxicity and convenient use, or research and improvement of radiation therapy technology for malignant t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D3/00
Inventor 杨阳骆晓梅王路路朱斌孙阳马文青
Owner 徐州医学院附属淮海医院
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