Hydrogel of composite semipermeable membrane and preparation method thereof

A composite semi-permeable membrane, hydrogel technology, applied in the fields of medical science, absorbent pads, layered products, etc., can solve the problems of residues, potential safety hazards, toxicity of small molecular initiators, etc., and achieve extended use time and high transparency. , the effect of expanding the use function and application scope

Inactive Publication Date: 2014-03-05
长春吉原生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the Chinese patent application 201110161595.5 published on January 25, 2012 provides a preparation process for wound dressings, which realizes the combination of hydrogel and high-elastic polyurethane film, but because small molecule photoinitiators are added in the

Method used

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  • Hydrogel of composite semipermeable membrane and preparation method thereof

Examples

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Example Embodiment

[0032] Example 1

[0033] 8% by mass of polyvinylpyrrolidone and 2% carrageenan were prepared into an aqueous solution, after physical methods were preformed, it was coated with a polyurethane film using a coating process to form a coil, and then subjected to cobalt source radiation treatment with a radiation dose of 18kGy to obtain The hydrogel of the composite polyurethane film, when the material absorbs water up to a swelling rate of 500%, it still maintains the close combination of the hydrogel and the film.

Example Embodiment

[0034] Example 2

[0035] The polyacrylamide is soaked, and then formulated into an aqueous solution of 60% by mass. The foam is discharged at 0.08MPa, and then filled into a tray of a certain shape, covered with a polyethylene terephthalate film, and then treated with cobalt The source radiates 35kGy to form the hydrogel material of the composite polyethylene terephthalate film. When the swelling rate reaches 1400%, the hydrogel and the film are still tightly bonded.

Example Embodiment

[0036] Example 3

[0037] The mass percentage of 16% sodium alginate, 0.8% hyaluronic acid, 1% propylene glycol was prepared into an aqueous solution, and the crosslinking agent CaCl2 aqueous solution was added dropwise while stirring rapidly, and then coated on the low-density polyethylene film. Electron accelerated radiation of 42kGy to obtain a composite low-density polyethylene film hydrogel, which still maintains the close combination of the hydrogel and the film when the swelling rate reaches 1200%.

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Abstract

The invention relates to a hydrogel of a composite semipermeable membrane and a preparation method thereof. The hydrogel comprises a semipermeable membrane and a hydrogel functional layer, wherein one side of the hydrogel functional layer is attached to the semipermeable membrane; the hydrogel functional layer is prepared from 10-90wt% of hydrophilic polymer material and 90-10wt% of water by adopting any one or combination of more than two of physical crosslinking, chemical crosslinking and radiation crosslinking. The hydrogel material prepared by the method has excellent performances such as high moisture content of the hydrogel and good biocompatibility, also has the characteristics of controlled moisture release rate of the semipermeable membrane; the service time of the hydrogel is prolonged; meanwhile, one side of the semipermeable membrane can be further combined with other accessories such as an adhesive tape, so as to meet more complicated functional requirements.

Description

technical field [0001] The invention relates to a hydrogel of a composite semipermeable membrane and a preparation method thereof. Background technique [0002] Hydrogel materials often need to be combined with some kind of support material to maintain a certain shape and perform specific functions. For example, in the application of medical dressings, hydrogel materials have good biocompatibility, conformability, air permeability and transparency, and the composite support materials also need to have good conformity, breathability and transparency, and reach With a certain anti-peeling strength, such a composite material will not affect the excellent performance of the hydrogel material itself while maintaining a certain shape. Currently common support materials such as sponges, foam materials, non-woven fabrics, etc., have disadvantages such as poor conformability and poor transparency. In contrast, many semi-permeable membrane materials have good conformability, air per...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/32A61L15/28A61L15/24A61L15/26B32B5/00
Inventor 余航于春暖王靖哲王栗周德根陈亮祝丽丹
Owner 长春吉原生物科技有限公司
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