Trithioadamantane derivatives, preparation methods and applications thereof
A technology of trithioadamantane and its derivatives, applied in biochemical equipment and methods, DNA preparation, chemical instruments and methods, etc., can solve the problems of poor chemical stability of sulfhydryl groups, influence on test precision, and generation of by-products, etc., to achieve Improved shelf storage time, high stability, and smooth lifting effects
Active Publication Date: 2016-05-25
苏州道尔盾基因科技有限公司
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Problems solved by technology
In these existing technologies, the connection of biomolecules and gold materials is usually achieved through the strong adsorption of single or multiple thiol groups attached to the biomolecules to the gold surface. However, due to the poor chemical stability of thiol groups, they are extremely vulnerable to oxygen, It is degraded by the action of light and produces by-products, which then interfere with the subsequent reaction or affect the precision of the test
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[0053] As previously mentioned, the present invention provides a kind of 2,4,9-trithio-hetero-[3.3.1.13,7]tricyclodecane-7-carboxylate (also known as "trithioadamantane") alkane derivatives"), using the three sulfur contained in it to chelate the metal surface to obtain a very high stability of the metal surface coating, and by applying it to biological, chemical molecules or groups and gold materials The connection can effectively improve the effects of various reactions based on the connection, such as the efficiency of the reaction, the accuracy of the result, and so on.
[0054] As one of the application schemes, the present invention can be applied to gene sequencing, a method for detecting gene sequence variation of a single gene in a 20-30 base DNA sequence by analyzing the thermal stability of the DNA double helix. This method (SNP detection) has been widely used in the diagnosis of genetic diseases, forensic examination, and identification of pathogenic microorganisms...
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The invention discloses a trithio-substituted adamantane derivative, and a preparation method and application thereof. The trithio-substituted adamantane derivative possesses a structure shown in the specification, wherein R is one arbitrary group. The provided trithio-substituted adamantane derivative possesses good stability, and because the derivative is chelated with metal surface via the three sulfur atoms, extremely high metal surface coating stability is obtained, and thus the stability of the connection between a biological / chemical molecule or a biological / chemical group and a metal material is guaranteed, and the stability includes but not limited to chemical stability, optical stability, temperature stability, biological stability, electrochemical stability and electric stability, and thus the smooth performing of correlated experiments and / or the accuracy of correlated experiment results are (is) facilitated, and the shelf storage time of correlated products is prolonged.
Description
technical field [0001] The invention particularly relates to a trithioadamantane derivative and its preparation method and application. Background technique [0002] At present, the industry has developed a variety of technologies to build biological detection kits, sensors or three-dimensional nanostructure materials by connecting biomolecules to gold nanoparticles, gold nanoparticles on the surface of platinum, gold electrodes, gold nanofilms and other materials. . In these existing technologies, the connection of biomolecules and gold materials is usually achieved through the strong adsorption of single or multiple thiol groups attached to the biomolecules to the gold surface. However, due to the poor chemical stability of thiol groups, they are extremely vulnerable to oxygen, It is degraded by the action of light and produces by-products, which in turn interfere with the subsequent reaction or affect the precision of the test. Contents of the invention [0003] One o...
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Login to View More IPC IPC(8): C07D495/18C07F9/6561C12N15/11C12N15/10C12Q1/68G01N21/31G01N21/552
CPCC07D495/18C07F9/6561C12Q1/6827G01N21/82G01N2021/825C12Q2563/137C12Q2527/101
Inventor 胡军方晨
Owner 苏州道尔盾基因科技有限公司