Technology of preparing nanometer traditional Chinese medicine material by liquid-phase shear dispersion

A technology of nanometer Chinese herbal medicines and Chinese herbal medicines, applied in the direction of food preparation, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of improving bioavailability, simple operation, and conducive to industrialization

Active Publication Date: 2014-03-12
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the absorption, metabolism, and excretion of drugs by biological organisms are extremely complex processes. The pharmacological effects of traditiona

Method used

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  • Technology of preparing nanometer traditional Chinese medicine material by liquid-phase shear dispersion
  • Technology of preparing nanometer traditional Chinese medicine material by liquid-phase shear dispersion
  • Technology of preparing nanometer traditional Chinese medicine material by liquid-phase shear dispersion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 200 g of Radix Astragali, dry at 45° C., pulverize with a pulverizer, and pass through a 100-mesh sieve to obtain 150 g of medicinal material particles larger than 100 mesh. Put the medicinal material granules in a shear tank filled with deionized water, the mass ratio of medicinal material granules to deionized water is 1:10, disperse evenly, and soak for 1 hour. Cooling water is passed into the jacket of the shear tank to control the working temperature at room temperature. Then carry out continuous shearing and crushing, the shearing speed is 16000 r min -1 , the shearing time is 40min. Under the condition of a temperature of 45 DEG C, the astragalus suspension is dried by vacuum drying, the nano astragalus particles are gathered into a thin film, and then dispersed to obtain the nano astragalus particles.

Embodiment 2

[0030] Weigh 500 g of lily medicinal material, dry at 30° C., pulverize with a pulverizer, and pass through a 100-mesh sieve to obtain 470 g of medicinal material particles larger than 100 mesh. The medicinal material granules were placed in a shear tank filled with physiological saline, the mass ratio of the medicinal material granules to the physiological saline was 1:20, after they were evenly dispersed, soaked for 0.5h. Cooling water is passed into the jacket of the shear tank to control the working temperature at room temperature. Then carry out continuous shearing and crushing, the shearing speed is 18000 r min -1 , the shearing time is 30min. Under the condition of a temperature of 30° C., the lily suspension is dried by vacuum microwave drying, and the nano-lily particles are aggregated into a thin film, which is then dispersed to obtain the nano-sized lily particles.

Embodiment 3

[0032] Weigh 100 g of pilose antler medicinal material, dry it at 25° C., pulverize it with a pulverizer, and pass through a 100-mesh sieve to obtain 80 g of medicinal material particles larger than 100 mesh. Put the medicinal material granules in a shear tank filled with olive oil, the mass ratio of the medicinal material granules to olive oil is 1:5, after they are evenly dispersed, soak for 2 hours. Cooling water is passed into the jacket of the shear tank to control the working temperature at room temperature. Then carry out continuous shearing and crushing, the shearing speed is 20000 r min -1 , the shearing time is 20min. The suspension of nano velvet antler is obtained, and then it is directly used in the preparation of nano velvet velvet soft capsules.

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Abstract

The invention discloses a technology of preparing a nanometer traditional Chinese medicine material by liquid-phase shear dispersion. According to the technology, a traditional Chinese medicine material is used as a raw material, and the nanometer traditional Chinese medicine material having a particle diameter of 50-300 nm is rapidly prepared by utilization of a high-shear dispersion smashing technology. The traditional Chinese medicine material can be prepared into solid nanoparticles and also can be prepared into nanometer traditional Chinese medicine suspension.

Description

technical field [0001] The invention belongs to the technical field of preparation technology of nanometer Chinese medicine. The technology uses single Chinese medicinal material and compound Chinese medicine as raw materials, and rapidly prepares granules in a liquid phase environment through high shear dispersing emulsifier (HSDE for short). Nano Chinese medicine particles with a diameter of 50-300nm. Background technique [0002] Although modern life science has made great progress, the health problems faced by human beings are still serious, and modern medicine obviously cannot solve all diseases and health problems. With the development of society and the transformation of people's lifestyle, the light of traditional medicine is more brilliant in the new era. The current predicament faced by chemicals is in stark contrast to the Green Peace thought of people returning to nature. The development and research of traditional Chinese medicine has become a hot spot in the w...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K36/481A61K36/8967A61K36/815A61K35/32A23L1/29A23L33/00
Inventor 裴栋邸多隆
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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