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Application of Tripterygium wilfordii alkaloid extract in preparation of drugs used for preventing or treating avian influenza

A tripterygium wilfordii alkaloid and extract technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve the problems of strong irritation and corrosiveness of the environment and animals, unsuitable disinfection, and high disinfection costs.

Inactive Publication Date: 2014-03-12
丁国华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, although there are disinfectant products on the domestic market, such as aldehyde disinfectants, chlorine-containing disinfectants and alkaline disinfectants, etc., these disinfectants are all artificially synthesized chemicals, which are harmful to the environment during use. and animals cause strong irritant and corrosiveness, thus limiting the use of these commonly used disinfectants
Although the anti-influenza drug "Tamiflu" has an effective effect on the treatment of bird flu, such drugs are expensive, and the cost of disinfection is too high, so it is not suitable to be used as a disinfectant to disinfect the environment and animal bodies in a large area.
In addition, the bird flu virus is constantly mutating, and it is easy to develop drug resistance when used alone

Method used

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  • Application of Tripterygium wilfordii alkaloid extract in preparation of drugs used for preventing or treating avian influenza
  • Application of Tripterygium wilfordii alkaloid extract in preparation of drugs used for preventing or treating avian influenza
  • Application of Tripterygium wilfordii alkaloid extract in preparation of drugs used for preventing or treating avian influenza

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: the research of Tripterygium wilfordii on the effect of avian influenza virus

[0011] Chicken Embryo Test and Determination of Therapeutic Index

[0012] 1. Experimental materials

[0013] Test drug: Tripterygium wilfordii alkaloid extract of the present invention;

[0014] Positive control substance: amantadine (purchased from Shijiazhuang Shengdian Pharmaceutical Co., Ltd.);

[0015] Blank control: distilled water;

[0016] Virus source: chicken-derived H5 subtype avian influenza virus [AIV (H5N1)] (from the virus room of the Animal Institute of South China Agricultural University);

[0017] Experimental chicken embryos were purchased from the Experimental Poultry Farm of South China Agricultural University.

[0018] 2. Experimental method

[0019] 1) Determination of the half-inhibitory dose (IC) of the test drug 50 )

[0020] 2) Determine the half toxic dose of the drug

[0021] 3) Viral potency of test drugs

[0022] The half effective dose ...

Embodiment 2

[0028] Embodiment 2: the test of the viral pneumonia that treatment H5N1 type avian influenza virus causes

[0029] 1. Materials

[0030] Test drug: Tripterygium wilfordii alkaloid extract of the present invention;

[0031] Positive control substance: amantadine (purchased from Shijiazhuang Shengdian Pharmaceutical Co., Ltd.);

[0032] Blank control: normal saline;

[0033] Experimental animals: Kunming mice (6 weeks old, mixed male and female) provided by the Experimental Animal Laboratory of Southern Medical University were injected with H5N1 virus to prepare a mouse viral pneumonia model.

[0034] 2. Experimental method:

[0035] 30 mice were randomly divided into 3 groups. They were low (0.36mg / ml), medium (0.49mg / ml), high dose (0.72mg / ml), amantadine (0.5mg / ml) and blank control groups respectively. The blank control group was intraperitoneally injected with normal saline at 15ml / kg; the amantadine group was injected intraperitoneally at 15ml / kg for 7 consecutive da...

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Abstract

The invention discloses application of a Tripterygium wilfordii alkaloid extract in preparation of drugs used for preventing or treating avian influenza, in preparation of drugs used for treating viral pneumonia caused by H5N1 type avian influenza virus and in preparation of a disinfectant for avian influenza. The Tripterygium wilfordii alkaloid extract may be a commercially available Tripterygium wilfordii alkaloid extract or is prepared by using technology known to the person skilled to the art. A variety of conventional preparations can be prepared from the Tripterygium wilfordii alkaloid extract according to conventional technology in the field of medicament and include, but is not limited to, an aerosol, an injection, an oral liquid, a tablet and a capsule.

Description

technical field [0001] The invention relates to the use of tripterygium wilfordii extract in preparing medicines for preventing and treating bird flu and the use of tripterygium wilfordii extract in preparing bird flu disinfectant. Background technique [0002] Avian influenza is a severe infectious disease of poultry caused by type A influenza virus, which is extremely harmful to the poultry industry and endangers human life and health. In 2002-2003, highly pathogenic H5N1 avian influenza broke out successively in Southeast Asian countries, central and southern provinces of my country, Hong Kong and Taiwan. Human-to-human transmission, causing human infection and death cases. Because avian influenza virus is a subtype of influenza virus, various H antigens and N antigens can be combined arbitrarily to produce new virus variants. Therefore, it is very difficult to prevent and control avian influenza. Avian influenza has become the number one disease in the poultry industry. ...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61P11/00A61P31/16A61K125/00
Inventor 丁国华
Owner 丁国华