Effervescent tablet with effects of clearing heat, detoxifying, dispelling pathogenic wind and reducing phlegm and preparation method thereof

A technology for dispelling wind, removing phlegm, clearing heat and detoxifying, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, antipyretics, etc. The effect of fishy smell, improving taste and strong stability

Active Publication Date: 2014-03-12
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that in the prior art, after the β-cyclodextrin inclusion complex is performed on the artificial bezoar in the Anering pharmaceutical composition, the loss of bilirubin is serious, thereby greatly reducing the efficacy of the drug, thereby providing An effervescent tablet with high efficacy, good water solubility and strong stability, which has the functions of clearing away heat and detoxification, dispelling wind and resolving phlegm, and its preparation method

Method used

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  • Effervescent tablet with effects of clearing heat, detoxifying, dispelling pathogenic wind and reducing phlegm and preparation method thereof
  • Effervescent tablet with effects of clearing heat, detoxifying, dispelling pathogenic wind and reducing phlegm and preparation method thereof
  • Effervescent tablet with effects of clearing heat, detoxifying, dispelling pathogenic wind and reducing phlegm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0211] The present embodiment provides an effervescent tablet with functions of clearing away heat and detoxification, expelling wind and resolving phlegm, which is prepared by the following method:

[0212] (1) Weigh 150g of safflower and 210g of sandalwood. After mixing, crushing and sieving, the volatile oil is extracted by supercritical carbon dioxide extraction method. The extraction pressure is 35MPa, the extraction temperature is 45°C, and the extraction time is 1 hour. and dissolve it in 95% ethanol to form a 45% volume percent ethanol solution of volatile oil, then add the volatile oil ethanol solution to 4% by weight aqueous solution of β-cyclodextrin, the volatile oil and the The weight ratio of β-cyclodextrin is 1:5, mix well, react at 40°C for 4 hours, refrigerate, filter with suction, and dry the precipitate in vacuum at 40°C to obtain the β-cyclodextrin inclusion complex of volatile oil;

[0213] (2) Weigh 150g of licorice, 170g of alpine horseradish, 150g of ro...

Embodiment 2

[0219] The present embodiment provides an effervescent tablet with functions of clearing away heat and detoxification, expelling wind and resolving phlegm, which is prepared by the following method:

[0220] (1) Weigh 159.9g of safflower and 200.1g of sandalwood. After mixing, crushing and sieving, the volatile oil is extracted by supercritical carbon dioxide extraction method. The extraction pressure is 35MPa, the extraction temperature is 45°C, and the extraction time is 1 hours, and dissolved it in 95% ethanol to form a 55% ethanol solution of volatile oil by volume, then added the ethanol solution of volatile oil to 6% by weight of β-cyclodextrin aqueous solution, the volatile oil and The weight ratio of the β-cyclodextrin is 1:10, mix well, react at 40°C for 4 hours, refrigerate, filter with suction, and dry the precipitate in vacuum at 40°C to obtain the β-cyclodextrin inclusion compound of the volatile oil thing;

[0221] (2) Weigh 159.9g of licorice, 159.9g of alpine ...

Embodiment 3

[0227] The present embodiment provides an effervescent tablet with functions of clearing away heat and detoxification, expelling wind and resolving phlegm, which is prepared by the following method:

[0228] (1) Weigh 170g of safflower and 190g of sandalwood. After mixing, crushing and sieving, the volatile oil is extracted by supercritical carbon dioxide extraction method. The extraction pressure is 35MPa, the extraction temperature is 45°C, and the extraction time is 1 hour. and dissolve it in 95% ethanol to form a 50% volume percent ethanol solution of volatile oil, and then add the volatile oil ethanol solution to 5% by weight aqueous solution of β-cyclodextrin, the volatile oil and the β - The weight ratio of cyclodextrin is 1:4, mix well, react at 40°C for 4 hours, refrigerate, filter with suction, and dry the precipitate in vacuum at 40°C to obtain the β-cyclodextrin inclusion compound of volatile oil;

[0229] (2) Weigh 170g of licorice, 150g of alpine horseradish, 170...

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Abstract

The invention relates to an effervescent tablet with effects of clearing heat, detoxifying, dispelling pathogenic wind and reducing phlegm and a preparation method thereof. The effective pharmaceutical ingredient calculus bovis factitius in the effervescent tablet is subjected to the following treatment: firstly melting solid polyethylene glycol by heating and then dispersing the calculus bovis factitius into the melted polyethylene glycol; ensuring that the polyethylene glycol and the calculus bovis factitius form a stable dispersion body so as to improve the stability of the calculus bovis factitius medicine component; then conducting inclusion on the dispersion body through cyclodextrin to form a calculus bovis factitius inclusion compound; finally preparing the effervescent tablet with the calculus bovis factitius inclusion compound. The prepared effervescent tablet has the characteristics of good pharmaceutical effect, excellent water solubility, high stability, good taste and the like.

Description

technical field [0001] The invention relates to an effervescent tablet with functions of clearing away heat and detoxification, expelling wind and resolving phlegm and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Anerning Granules is a classic Tibetan medicine for children. It is prepared from 9 medicinal materials, i. The medicine has the functions of clearing away heat and detoxification, dispelling wind and resolving phlegm, and has a good curative effect in clinical treatment of children with wind-heat cold, pneumonia, bronchitis and the cough and fever caused by it. In addition, considering the physiological and pathological characteristics of children, it has been clinically verified that An Er Ning Granules not only has a significant curative effect, but also has no toxic and side effects, so it is favored by patients clinically. [0003] However, since the components of the above-mentioned Anerning Granul...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K47/34A61K47/48A61K9/46A61P11/00A61P11/10A61P11/14A61P29/00A61K35/413
Inventor 王海苹杨文钰张栋李怀平
Owner JINHE TIBETAN MEDICINE
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