Glucomannan succinate preparation method

A technology of glucomannan and succinate, applied in the fields of cosmetics, medicines and health food

Inactive Publication Date: 2014-03-12
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on succinate modification of glucomannan has not been reported

Method used

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  • Glucomannan succinate preparation method
  • Glucomannan succinate preparation method
  • Glucomannan succinate preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Preparation of Baiji polysaccharide succinate described in this example: The preparation of raw materials such as Baiji polysaccharide 70 (BT70, Mw=70kDa) was carried out with reference to the patent literature (application number 201010166718.X). Weigh 10 g of the dried BT70 raw material respectively, put it in a 50 mL three-neck flask, add 15 mL of DMF, and stir to dissolve at 100°C. Add 3 mL of N,N-diisopropylethylamine at the set temperature, and add succinic anhydride according to the molar ratio of raw material monosaccharide group and succinic anhydride is 1:1, react for a certain period of time, and take samples regularly. Add 2 times the amount of absolute ethanol to the reaction solution to precipitate a precipitate, filter it with suction, wash with absolute ethanol 3-4 times, and dry the obtained white powder in an oven at 60°C to obtain a reaction product. The determination of the succinyl substitution degree refers to the literature method of Takahara et a...

Embodiment 2

[0019] The preparation of the white and polysaccharide succinate described in this example: Weigh 1.0 g of dried BT70 raw materials respectively, adopt a reaction temperature of 100° C., except that the molar ratio of BT70 and succinic anhydride is changed to 1:0.5, 1:1, Except for 1:3, 1:5, and 1:10, the rest of the operations refer to Example 1. The influence of the molar feed ratio of BT70 and succinic anhydride on the reaction was investigated, and the measurement results are shown in Table 2.

[0020] The influence of table 2 reaction raw material mol ratio on the degree of substitution of BT70 succinyl ester

[0021]

[0022] Structural testing of reaction products: (1) Infrared spectrum analysis results show that BT70 and its succinate reaction products BT70-S1 (DS0.38), BT70-S2 (DS0.85) etc. are at 1750cm -1 The corresponding carbonyl characteristic absorption peak in the vicinity is obviously enhanced, see the attached figure 1 (2) H NMR analysis results show tha...

Embodiment 3

[0025] Preparation of glucomannan succinate described in this example: Weigh dry BT40 (1.0g), BT70 (1.0g), BT180 (0.5g), konjac polysaccharide (0.2g) and aloe polysaccharide (0.5g) respectively g) Raw materials, the molar ratio of polysaccharide to succinic anhydride is 1:10, the reaction temperature is 100°C, the reaction time is 6h, and the rest of the operations are carried out with reference to Example 1. The preparation of different glucomannan succinic anhydride was investigated respectively, and the determination results are shown in Table 3.

[0026] Table 3 Degree of substitution of different glucomannan succinyl esters

[0027]

[0028] Conclusion: The corresponding succinyl ester products of different glucomannans can be obtained by using the above reaction method.

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Abstract

The invention discloses a glucomannan succinate preparation method. The method adopts the natural materials of konjac polysaccharide, rhizoma bletillae polysaccharide and aloe polysaccharide or hydrolysates of the konjac polysaccharide, the rhizoma bletillae polysaccharide and the aloe polysaccharide, and uses an amide solvent as a medium, succinic anhydride as an acyl donor and N,N-diisopropylethylamine as a catalyst, the materials are reacted at the temperature of 80-110 DEG C for 2-6 hours, and ethyl alcohol or acetone, amount of which is 2-3 times that of the mixture, is added to precipitate, filtering and drying are performed to obtain the glucomannan succinate with the molar substitution degree of 0.1-1.0. According to the preparation method provided by the invention, the glucomannan succinate with controllable succinyl group substitution degree and good uniformity is directly obtained through one-step reaction, and the preparation method has the advantages of simplicity and convenience in operation, easy control, applicability to industrial production and the like. The glucomannan succinate has remarkably enhanced water solubility and an anti-oxidation effect, and can be applied to the fields of foods, cosmetics and drugs.

Description

technical field [0001] The invention relates to a glucomannan succinate and a preparation method thereof, in particular to a glucomannan succinate with controllable succinyl substitution degree and good uniformity and a preparation method thereof, belonging to health food and cosmetics and pharmaceutical fields. technical background [0002] Glucomannan is a common natural viscous polysaccharide. Its main chain is composed of D-mannose and D-glucose. It is generally connected by β1-4 glycosidic bonds, and often has a partial branched structure and acetyl modification. Such polysaccharides are widely distributed, and such polysaccharides found in plants such as konjac polysaccharides, aloe polysaccharides, white polysaccharides, etc. are widely used in the fields of food, cosmetics, and pharmaceuticals. In addition, chemical modification of natural polysaccharides to obtain desired physical and chemical properties is an important method, which can further expand the applicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02
Inventor 刘江云王虎成彭芳李楠蔡培烈杨世林
Owner SUZHOU UNIV
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