Biological marker of male infertility and application thereof

A biomarker and male infertility technology, applied in the field of biomarkers, can solve the problems of inability to reflect sperm function, inaccuracy, and difficulty in diagnosing male infertility, and achieve the effects of avoiding body damage and facilitating access.

Inactive Publication Date: 2014-03-12
INST OF URBAN ENVIRONMENT CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional semen routine analysis (routine semen analysis such as sperm count, viability, motility and morphology) is a common method for judging male fertility at present, but it is still very inaccurate to predict male fertility status only by routine semen analysis
Clinically, the real cause of infertility in most male infertile patients is still unclear, especially in clinical practice, the routine semen analysis results of nearly 30% of male infertile patients are normal or close to normal. There are great difficulties in the diagnosis of male infertility. The main reason is that routine semen analysis indicators such as sperm count, viability, motility and morphology can only reflect the most basic semen quality, but not all sperm functions. Therefore, it is necessary to discover new biomarkers and assist traditional semen routine analysis to achieve accurate diagnosis of male infertility

Method used

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  • Biological marker of male infertility and application thereof
  • Biological marker of male infertility and application thereof
  • Biological marker of male infertility and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment

[0038] sample collection

[0039] Urine samples were obtained from 135 infertile male patients and 158 normal healthy male controls. In this paper, the male infertility patients refer to the fact that the male infertility patients are still infertile after more than one year of normal sexual life without contraceptive measures, but their spouses are evaluated as having normal reproductive function by clinical examination. Normal controls were males who had normal births with their spouses within one year. The average age of male infertility patients was 29.45+4.47, and the age range was 24-34 years old; the average age of normal control males was 29.11+5.07, and the age range was 24-34 years old. All urine samples were collected in the Affiliated Hospital of Nanjing Medical University, and all subjects signed written informed consent.

[0040] urine preparation

[0041] Before analysis, dissolve the urine samples at room temperature. Add 300 μL of deionized water to 300 μL...

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Abstract

The invention discloses a method for diagnosing male infertility, and discloses a biological marker indicating male infertility, a method for indentifying and detecting the biological marker indicating male infertility, and a kit for diagnosing or detecting male infertility. The method combined with seminal fluid routine inspection helps to realize the accurate diagnosis on male infertility.

Description

technical field [0001] The present invention relates to biomarkers, especially to biomarkers of male infertility, including methods for identifying and screening biomarkers related to male infertility, including methods for detecting biomarkers of male infertility, and methods for Kits for the diagnosis or detection of male infertility. Background technique [0002] Male infertility has become a major public health problem worldwide. Traditional semen routine analysis (routine semen analysis such as sperm count, viability, activity rate, and morphology) is a common method for judging male fertility at present, but it is still very inaccurate to predict male fertility status only by routine semen analysis. Clinically, the true cause of infertility in the vast majority of male infertile patients is still unclear, especially in clinical practice, the routine semen analysis results of nearly 30% of male infertile patients are normal or close to normal. There are great difficul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53G01N30/02
CPCG01N33/53G01N30/02G01N2030/027G01N2800/367
Inventor 张洁申河清王展林
Owner INST OF URBAN ENVIRONMENT CHINESE ACAD OF SCI
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