37 results about "MALE INFERTILITY DISORDERS" patented technology

The invention discloses a method for diagnosing male infertility, and discloses a biological marker indicating male infertility, a method for indentifying and detecting the biological marker indicating male infertility, and a kit for diagnosing or detecting male infertility. The method combined with seminal fluid routine inspection helps to realize the accurate diagnosis on male infertility.

The invention provides a decoction for promoting fertility. The decoction has functions of nourishing liver and kidney, warming yang and securing essence and can be mainly used for treating male infertility with an excellent effect; the male infertility comprises the following symptoms: sexual disorders such as impotence, spermatorrhea and anejaculation, dysspermia such as oligospermia, low active ratio, dead spermatozoon and nonliquefaction of semen, yang deficiency and the like. Traditional Chinese medicine composition of the decoction is prepared from the following 36 compatible raw materials according to weight: prepared rhizome rehmannia, Chinese yam, dogwood, poria cocos, rhizoma alismatis, salivia chinensis, semen allii tuberose, Chinese wolfberry, rubus idaeus, flatstem milkvetch seed, semen cuscutae, radix achyranthis bidentatae, cistanche, human placenta, bombyx mori, isinglass and the like. The decoction is excellent in effect for treating infertility caused due to poor sperm motility or few sperms, excellent in effect for treating male infertility and quick in curative effect; the decoction is prepared from natural traditional Chinese medicine components, so that the decoction is free of side effect; the formula of the decoction has the functions of strengthening sperms and effectively increasing the number of the sperms.

Reagents, methods, and kits are described that are useful for fertility testing and that in many cases provides much faster, convenient and rapid determination of male infertility. The reagents described include properly glycosylated human ZP3, ZP2, ZP1, glycosylated peptides thereof, fusion proteins such as green fluorescent protein—ZP3, non-covalent complexes of ZP2 with ZP3, fusion protein of ZP2–ZP3, solid phase materials such as agarose beads coated with binding agents such as ZP3, and other artificial zona. Methods are provided that, in many cases convert a complex biological event into a well defined biochemical binding event based on one or more of the reagents. Such methods are much easier to set up and monitor, allowing more convenient and inexpensive diagnostic testing for male fertility. The acrosome reaction is detected in other embodiments by virtue of quantitating one or more released substances. Kits are further provided that contain one or more reagents useful for testing at a diagnostic laboratory or other facility.

The invention provides a compound for use in treating or preventing a disease or condition selected from cystic fibrosis, chronic obstructive pulmonary disease (COPD), asthma, mild pulmonary disease, bronchitis, bronchiectasis, idiopathic bronchiectasis, allergic bronchopulmonary aspergillosis, sinusitis, rhinosinusitis, CFTR-related metabolic syndrome (CRMS), pancreatitis, idiopathic chronic pancreatitis and Sjörgren's syndrome, or for use in preventing male infertility caused by congenital absence of the vas deferens, in a patient by modulating CFTR activity, which compound is 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a composition comprising (i) 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (ii) a leukotriene receptor antagonist. The invention also provides a composition comprising (i) 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (ii) a CFTR potentiator or a CFTR corrector.

The invention provides a decoction for promoting the production of sperms. The decoction has the function of reinforcing kidney to replenish essence and is extremely good in treating effect for male infertility caused by spermatogenic failure. As a traditional Chinese medicine composition, the decoction is prepared from the following more than ten crude drugs by weight: epimedium herbs, radix polygoni multiflori preparata, radix rehmanniae preparata, astragalus, angelica sinensis, cistanche, tuckahoe, radix achyranthis bidentatae, barbary wolfberry fruits, semen cuscutae, cnidium monnieri, schisandra chinensis, placenta hominis and the like. The decoction is capable of reinforcing kidney to replenish essence for the male, rapid in taking curative effects for male infertility caused by spermatogenic failure and free of toxic or side effect for human bodies due to the addition of natural traditional Chinese medicine components. According to the formula, the decoction has the effects of strengthening sperms and effectively increasing the quantity of the sperms.

Methods and systems are provided for diagnosing male infertility relating to inadequate production of phosphatidic acid and are complementary to the routine tests, assessing sperm count, motility, viability, head morphology, and white blood cell count. Additional therapeutic methods, compositions and dosage forms are provided for treating male infertility that is related to inadequate production of phosphatidic acid. Such therapeutic approaches involve the use of phosphatidic acid or at least one of its precursors in the sperm intracellular signaling pathway.

A profertility composition for administration to infertile men with sperm oxidative stress is disclosed. The composition comprises a unique combination of a pharmaceutically acceptable vitamin E, vitamin C, selenium, zinc, folic acid, lycopene and at least one carnitine source.

The invention discloses a traditional Chinese medicinal composition for treating male infertility and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is characterized by comprising, by weight, 20-30 parts of prepared rehmannia roots, 6-15 parts of pulp of dogwood fruits, 20-30 parts of astragalus membranaceus, 6-9 parts of angelica sinensis, 10-20 parts of human placentas, 6-12 parts of stiff silkworms, 20-35 parts of silkworm excrement, 10-15 parts of rhizoma curculiginis, 10-15 parts of herba epimedii 15-25 parts of semen cuscutae, 20-40 parts of mulberry fruits, 9-18 parts of semen allii tuberosi, 3-9 parts of the root of three-nerved spicebush, 20-25 parts of cherokee rose fruits, 10-15 parts of rhizoma cibotii and 5-9 parts of cape jasmine. The traditional Chinese medicinal composition has the advantages that the prepared rehmannia roots serve as a monarch drug, the pulp of the dogwood fruits and the astragalus membranaceus serve as ministerial drugs, the angelica sinensis, the human placentas, the stiff silkworms, the silkworm excrement, the rhizoma curculiginis, the herba epimedii, the semen cuscutae, the mulberry fruits, the semen allii tuberosi, the root of three-nerved spicebush and the cherokee rose fruits serve as adjuvant drugs to purge the pathogenic fire and relieving restlessness, and the capejasmines serve as an envoy drug, which is free of toxic and side effects, so that the effect of tonifying yin and yang, replenishing qi and enriching the blood is achieved, and the traditional Chinesemedicinal composition can treat kidney diseases such as kidney deficiency, male sexual dysfunction and female sterility.

The invention relates to a medicine for treating male infertility, the key of which is that the active ingredient of the medicine is a medicine capsule prepared from twenty-four traditional Chinese medicines such as sea dog kidney and saffron, and three kinds of western medicines such as zinc sulfate. . The function is to nourish the liver and kidney, strengthen yang, generate essence and nourish essence, mediate kidney yin and yang, promote blood circulation and remove blood stasis, reduce heat and detoxify, antibacterial and anti-inflammatory, and increase the body's immunity. Its positive effects are: the present invention adopts the organic combination of Chinese and Western medicines, scientific prescription, high purity of active ingredients of the medicine, remarkable therapeutic effect, total clinical effective rate of 97.2%, convenient taking, short course of treatment, novel and simple preparation method, and can fully Bring into play the effect of the active ingredient of the medicine, and the price is relatively cheap. Indications: male infertility, impotence, premature ejaculation, etc. Dysfunctional disease.

The invention relates to a preparation method and application of a colorimetric array sensor of a zirconium-based metal-organic framework and single-stranded DNA modified gold nanoparticles. Six different single-stranded DNA sequences were designed to modify the surface of gold nanoparticles to form unique sensor recognition elements. The new material zirconium-based metal-organic framework can bind and precipitate single-stranded DNA sequence modification on gold nanoparticles through different intermolecular forces. After adding certain proteins or semen samples, their binding force can be accelerated or slowed down, affecting It aggregates to produce a detectable signal. Therefore, we can consider that these recognition elements have different interactions with different targets, and we can detect different targets obviously by analyzing the colorimetric response of each recognition element in combination. The invention can be used for the colorimetric array analysis of various proteins and male semen simply and efficiently, and provides detection basis for the analysis of male infertility.

The present disclosure generally relates to the field of infertility, and in particular male infertility. Accordingly, the present disclosure provides for compositions and methods for managing male infertility, caused by poor semen quality. More particularly, the present disclosure provides a therapeutic composition comprising a platelet rich plasma (PRP) or a growth factor concentrate derived therefrom and a thermoresponsive polymer. The present disclosure also relates to the compositions of PRP and the concentrate themselves. Consequently, methods to obtain the said compositions, along with therapeutic applications for treatment of infertility caused by poor semen quality are also provided.

The invention discloses the use of substance P in preparing medicine for treating male infertility. The present invention treats the azoospermia mouse model with substance P, and finds that substance P can effectively improve the spermatogenic function of the azoospermia mouse model induced by busulfan, and further confirms that substance P promotes the proliferation of spermatogenic cells To improve spermatogenesis; the invention provides new ideas and theoretical support for the treatment of male infertility.

The invention discloses an application of a traditional Chinese medicine composition in preparing medicine for treating male infertility. The traditional Chinese medicine composition of the present invention is composed of 8 traditional Chinese medicines such as astragalus, talc, and Prunella vulgaris.

The present invention relates to a pharmaceutical composition including vitrified periodontal tissue-derived mesenchymal stem cells for prevention or treatment of male infertility. The pharmaceutical composition for prevention or treatment of male infertility according to the present invention recovers sex hormone levels in seminiferous tubules of atrophic testes and blood to normal levels through improvement in the activity of lipid metabolism enzymes in the liver, thereby exhibiting remarkable prophylactic and therapeutic effects on male infertility. In addition, the periodontal tissue-derived mesenchymal stem cells which are an active ingredient in the present invention can be obtained in the most non-invasive manner and as such, are expected to be advantageously used as a cell therapy product for male infertility.

The invention relates to a traditional Chinese medicine formula for treating male infertility. The traditional Chinese medicine formula consists of 16 traditional Chinese herbal medicines including male silkworm moth, baked pangolin scales, tortoiseshells, agilawood, antler tablets, unprocessed rehmannia glutinosa, dogwood, cistanche, herba epimedii, peony bark, golden cypress, semen plantaginis, lycium barbarum, paeonia lactiflora, yam rhizome and poria cocos. Pharmacology experiments show that the traditional Chinese medicine formula has the effects of nourishing yin and clearing heat, tonifying kidney and generating seminal fluid, tonifying spleen and removing dampness as well as activating blood and removing stasis, testis, epididymis seminal vesicle and prostate can be nourished, the amount of sperms is increased, and the testicular spermatogenic function is covered; the traditional Chinese medicine formula has a remarkable effect in treating kidney-yin deficiency type semen quality abnormity and semen volume abnormity, immune infertility and unknown cause infertility.

The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating male infertility and a preparation method thereof. Made from the following raw materials in parts by weight: 5-10 parts of ginseng, 1-3 parts of velvet antler, 3-6 parts of actinolite, 5-10 parts of chives, 5-10 parts of cornus, purple river 5-15 parts of carnation, 10-15 parts of dodder, 5-10 parts of epimedium, 10-15 parts of Morinda officinalis, 6-12 parts of Cyperus cyperi, 3-6 parts of schisandra, 5-10 parts of raspberry, and shayuanzi 10-15 parts, Phellodendron 5-10 parts, Chuanxiong 3-10 parts. The composition of the present invention has the effects of nourishing qi and yang, nourishing kidney and replenishing essence, nourishing yin and clearing away heat, regulating qi and removing blood stasis; carefully selected and carefully selected, it starts with promoting the metaplasia of sperm, and promotes the production of kidney, heart, liver, spleen, etc. Focusing on the restoration of visceral and reproductive functions, clinical treatment of male infertility has achieved remarkable results.