Animal vagus nerve stimulation electrode and preparation method thereof

Abstract

The invention provides an animal vagus nerve stimulation electrode which comprises a pair of positive electrodes and a pair of negative electrodes. Each of the positive electrodes and the negative electrode is formed by two metallic silver sheets with the cross sections of C-shaped convolution. The silver sheets are arranged in a plastic pipe. The inner wall of the pipe is provided with a groove whose width is same with that of the silver sheet. The silver sheets is fully embedded with the groove through a biological glue with no gap, a round channel is formed after the silver sheets are buckled up and down, thus vagus nerve can be contained the round channel and has good contact. One end of each of the two silver sheets in the positive and negative electrodes is welded and connected respectively and passes through the pipe wall to be welded with a conductive wire outside a plastic pipe respectively. According to the animal vagus nerve stimulation electrode, the size of the electrode is reduced, the electrode can be implanted in the body of an animal such as a rabbit and a dog, winding nerve is convenient in the implantation into the body, the possibility of damaging the nerve is little, the contact effect with the nerve in the body is good, the experimental animal is in long-term tolerance, the electrode is conductive for a long time and is not easy to be corroded, the contact and conductive effects with the nerve are good, and the effect of repeated use is good.

Description

Technical field: [0001] The invention relates to the field of physics, in particular to an electronic device for small animal nerve experiments, in particular to an animal vagus nerve stimulating electrode and a preparation method thereof. Background technique: [0002] With the development of neuroelectrophysiology, various nerve electrical stimulations have been applied clinically and have achieved good curative effects, especially in the treatment of epilepsy by vagus nerve stimulation (VNS). It is difficult to obtain brain tissue from patients because of the particularity of the brain tissue and the reasons related to ethics and morality (even if the specimen is obtained, it is extremely unrealistic to simulate the real situation of VNS inhibiting epileptic seizures on isolated brain tissue), so it is necessary to Animals (such as rabbits and dogs) are tested in vivo to carry out relevant scientific research. However, in the prior art, no nerve stimulation electrodes th...

AI Technical Summary

Problems solved by technology

[0002] With the development of neuroelectrophysiology, various nerve electrical stimulations have been applied clinically and have achieved good curative effects, especially in the treatment of epilepsy by vagus nerve stimulation (VNS). It is difficult to obtain brain tissue from patients because of the particularity of the brain tissue and the reasons related to ethics and morality (even if the specimen is obtained, it is extremely unrealistic to simulate the real situation of VNS inhibiting epileptic seizures on isolated brain tissue), so it is necessary to Do experiments in animals (such as rabbits and dogs) and conduct relevant scientific research

However, in the prior art, nerve stimulation electrodes that can be implanted in small animals have not been found

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