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A kind of spherical SERS active substrate and preparation method thereof

An active substrate, spherical technology, applied in the field of materials, can solve problems such as troublesome, small substrate area, and numerous preparation steps

Active Publication Date: 2017-01-18
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparation steps are many, special equipment is required, the area of ​​the obtained substrate is small (usually only a few square centimeters), and it is difficult to realize the challenges of high-throughput preparation of SERS substrates; SERS substrates are mostly planar structures, which often need to be cut into smaller-area substrates when used, which is troublesome and time-consuming

Method used

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  • A kind of spherical SERS active substrate and preparation method thereof
  • A kind of spherical SERS active substrate and preparation method thereof
  • A kind of spherical SERS active substrate and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1 Gold (55nm) and resin assembled core-shell composite microspheres and their structural characterization

[0031] Cl-type anion exchange resin is first soaked with saturated NaCl aqueous solution, and then washed with deionized water until there is no free Cl - Finally, soak in 2mol / L NaOH aqueous solution to convert Cl-type resin into OH-type, then repeatedly wash with deionized water until neutral, repeat the treatment twice, soak it in 2mol / L mercaptoacetic acid-methanol solution, and stir at room temperature 12h, and then washed repeatedly with anhydrous methanol to obtain thiol-functionalized resin microspheres. Take the diameter as 55nm and the concentration as 10 9 -10 11 NPs / mL gold particles-ethanol solution 12mL, then add mercapto resin microspheres 0.018g, oscillate at 30°C (120 rpm) for 3h, then sonicate in an ultrasonic bath for 30s to remove the free gold physically adsorbed on the surface of the self-assembly After particle removal, wash with ...

Embodiment 2

[0032] Embodiment 2 gold (30nm) and resin assembly core-shell composite microsphere

[0033] Take the diameter as 30nm and the concentration as 10 9 -10 11 NPs / mL gold particle-methanol solution 1200mL, then add 1.8g mercapto resin microspheres, shake at 40°C (120 rpm) for 4h, and then ultrasonicate in an ultrasonic bath for 30s to remove the free gold physically adsorbed on the surface of the self-assembly After particle removal, wash with anhydrous methanol three times to obtain gold (30nm)-resin core-shell composite microspheres (about 5040 spheres), which are stored in anhydrous methanol for later use.

Embodiment 3

[0034] Embodiment 3 gold (80nm) and resin assembly core-shell composite microsphere

[0035] Take the diameter as 80nm and the concentration as 10 9 -10 11 NPs / mL gold particle-methanol solution 120mL, then add mercapto resin microspheres 0.18g, oscillate at 45°C (120 rpm) for 3h, then ultrasonicate in an ultrasonic bath for 30s to remove the free gold physically adsorbed on the surface of the self-assembled body After particle removal, wash with anhydrous methanol three times to obtain gold (80nm)-resin core-shell composite microspheres (about 500 spheres), which are stored in anhydrous methanol for later use.

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Abstract

The invention discloses a spherical active substrate and a preparation method thereof and belongs to the technical field of materials. According to the spherical active substrate and the preparation method thereof, by assembling gold particles with the diameter of 30-160nm on the surface of a thiol-functional anion exchange resin microsphere at room temperature through one step, a core-shell composite microsphere can be prepared, wherein a single densely distributed gold particle assembling layer serves as a shell, and a resin microsphere serves as a core. The core-shell composite microsphere has a strong enhancing effect on a Raman signal of thiophenol and can be used as an active substrate for surface enhanced Raman scattering (SERS) detection. According to the preparation method of the spherical SERS active substrate, the spherical SERS active substrate which is remarkable in enhancing effect and high in stability can be prepared with high efficiency (preparation of 2,800 microspheres through 1g of resin) and low cost.

Description

technical field [0001] The invention relates to a SERS active substrate, in particular to a spherical SERS active substrate and a preparation method thereof, belonging to the technical field of materials. Background technique [0002] Surface-enhanced Raman spectroscopy (SERS) is a high-efficiency analytical detection technique with great application prospects in key scientific fields such as life, medicine, chemistry, environment and food safety. Based on the long-range electromagnetic enhancement and short-range chemical enhancement effects, the SERS active substrate with nanostructures such as Au and Ag on the surface can amplify the weak Raman signal by 108 times or even greater. Recently, regular and ordered array-type Au and Ag nanostructures have become the representative of a new generation of SERS active substrates, such as: ordered self-assembly of nanoparticles, regular structured surfaces constructed by lithography combined with metal plating technology, Mechani...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65B01J13/02
Inventor 刘雪锋孙春生王晶
Owner JIANGNAN UNIV