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Panax japonicus saponins as well as preparation method and application thereof

A technology of bamboo ginseng saponins and bamboo ginseng, which can be used in medical formulas, medical preparations containing active ingredients, plant raw materials, etc., and can solve problems that have not been reported or mentioned the inhibitory effect of bamboo ginseng extracts

Inactive Publication Date: 2014-03-26
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The prior art does not mention that the extract of bamboo ginseng has an inhibitory effect on the specific pathological process of liver fibrosis, and whether the extract of bamboo ginseng has the effect of treating liver fibrosis has not been reported in the prior art

Method used

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  • Panax japonicus saponins as well as preparation method and application thereof
  • Panax japonicus saponins as well as preparation method and application thereof
  • Panax japonicus saponins as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: Preparation of Bamboo Ginseng Extract

[0070] The implementation steps of this embodiment are as follows:

[0071] A. Preparation of bamboo ginseng raw material solution

[0072] Crush the bamboo ginseng raw material to 20 mesh, and soak the crushed bamboo ginseng in the ethanol aqueous solution for 3 hours according to the weight ratio of the bamboo ginseng participating in the volume fraction of 62% ethanol aqueous solution for 3 hours, and then heat and reflux for extraction 4 times, 1 hour each time , combine the extracts to obtain the raw material solution to be treated, add an appropriate amount of NaCl to the raw material solution, so that the NaCl concentration in the raw material solution reaches 0.010mol L -1 , finally adding HCl or NaOH to the raw material solution to adjust the pH to 5;

[0073] B. Formation of foam separation device

[0074] The foam separation device is composed of seven parts: air compressor 1, glass rotameter 2, gas dis...

Embodiment 2

[0085] Embodiment 2: the preparation of Panax ginseng extract

[0086] The implementation steps of this embodiment are as follows:

[0087] A. Preparation of bamboo ginseng raw material solution

[0088] Grind the bamboo ginseng raw material to 30 mesh, soak the crushed bamboo ginseng in the ethanol aqueous solution according to the weight ratio of the bamboo joint participation volume fraction of 66% ethanol aqueous solution, soak for 4 hours, and then heat and reflux for extraction twice, each time 4h, combine the extracts to obtain the raw material solution to be treated, add an appropriate amount of NaCl to the raw material solution, so that the NaCl concentration in the raw material solution reaches 0.018mol L -1 , finally adding HCl or NaOH to the raw material solution to adjust the pH to 3;

[0089] B. Formation of foam separation device

[0090] The structure of the foam separation device of this embodiment is the same as that of Embodiment 1.

[0091] C. Foam sepa...

Embodiment 3

[0094] Embodiment 3: the preparation of Panax ginseng extract

[0095] The implementation steps of this embodiment are as follows:

[0096] A. Preparation of bamboo ginseng raw material solution

[0097] Grind the bamboo ginseng raw material to 40 mesh, soak the crushed bamboo ginseng in the ethanol aqueous solution according to the weight ratio of the bamboo joint participation volume fraction of 70% ethanol aqueous solution, soak for 2 hours, and then heat and reflux for extraction 5 times, each time 2h, combine the extracts to obtain the raw material solution to be treated, add an appropriate amount of NaCl to the raw material solution, so that the NaCl concentration in the raw material solution reaches 0.025mol L -1 , finally adding HCl or NaOH to the raw material solution to adjust the pH to 4;

[0098] B. Formation of foam separation device

[0099] The structure of the foam separation device of this embodiment is the same as that of Embodiment 1.

[0100] C. Foam se...

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Abstract

The invention relates to a panax japonicas extract as well as a preparation method and application thereof. According to the invention, the method comprises the steps of preparation of panax japonicas raw material liquid, formation of a foam separation device and foam separation. By utilizing a high-fat diet molding technology, research is conducted in application and effect of the panax japonicas extract in an animal body, and the experimental result shows that the panax japonicas extract has favorable liver-protection and lipid-lowering activity, can obviously inhibit the formation of liver fibrosis, and has a good therapeutic effect on the liver fibrosis.

Description

【Technical field】 [0001] The invention belongs to the specific application field of traditional Chinese medicine. More specifically, the present invention relates to a kind of bamboo ginseng saponin, also relates to the preparation method of said bamboo ginseng saponin, and also relates to the use of said bamboo ginseng saponin. 【Background technique】 [0002] Liver fibrosis is one of the important diseases that seriously threaten human health, and there is no satisfactory treatment so far. It is a pathological process in which abnormal proliferation of connective tissue in the liver caused by various pathogenic factors leads to excessive precipitation of diffuse extracellular matrix in the liver. Many chronic liver diseases can cause liver fibrosis. Hepatic fibrosis is mainly characterized by hepatic sinusoidal capillaryization and hepatic lobular and portal area fibrosis. Various chronic liver injuries can lead to excessive proliferation and abnormal deposition of extrace...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P1/16
Inventor 袁丁张长城刘朝奇王婷孙志伟周志勇崔倩倩万静枝何毓敏
Owner CHINA THREE GORGES UNIV
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