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Application of chitosan quaternary ammonium to contact lens care solution

A quaternary ammonium chitosan and contact lens technology, applied in the field of chitosan, can solve problems such as high cost, toxic reaction, and corneal damage

Inactive Publication Date: 2014-03-26
HAICHANG CONTACT LENSES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its complex preparation process and high cost, hyaluronic acid limits its application to a certain extent.
And the fungicide preservatives commonly used in the nursing solution, long-term use will damage the cornea to varying degrees, and even cause toxic reactions

Method used

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  • Application of chitosan quaternary ammonium to contact lens care solution
  • Application of chitosan quaternary ammonium to contact lens care solution
  • Application of chitosan quaternary ammonium to contact lens care solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The formula composition of contact lens care solution is as follows in mass percentage

[0028]

[0029] The balance is water for injection.

[0030] The antibacterial rate against E.coil was 99.98%, the antibacterial rate against S.aureus was 99.97%, and the contact angle on the silicon hydrogel was 30°.

Embodiment 2

[0032] The formula ingredients of contact lens care solution are as follows

[0033]

[0034] The balance is water for injection.

[0035] Suspension quantitative sterilization test shows that the antibacterial rate against E.coil is 100%, the antibacterial rate against S.aureus is 99.99%, and the contact angle on the silicon hydrogel is 24°.

Embodiment 3

[0037] The formula ingredients of contact lens care solution are as follows

[0038]

[0039] The balance is water for injection.

[0040] The suspension quantitative bactericidal test showed that the antibacterial rate against E.coil was 99.96%, and the antibacterial rate against S.aureus was 99.93%, and the contact angle on the silicon hydrogel was 38°.

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Abstract

The invention discloses application of chitosan quaternary ammonium to a contact lens care solution, wherein chitosan quaternary ammonium is used as an antibacterial humectant and has the effective content of 0.001%-2% by mass of the contact lens care solution. By applying chitosan quaternary ammonium with good moisture-absorption moisture-retention performances and strong antibacterial performance to the contact lens care solution as the antibacterial humectants, the obtained care solution has the antibiosis rate on E.coil of 99.95-100% and the antibiosis rate on S.aureus of 99.91-99.99%, and the contact angle on silicon hydrogel is 20 DEG-40 DEG. The advantages comprise that the natural substance is used as the humectant and the antiseptic of the contact lens care solution, and chitosan quaternary ammonium is endowed with new application.

Description

technical field [0001] The invention relates to the field of chitosan, in particular to the application of a quaternary ammonium salt chitosan in a new field. Background technique [0002] Chitosan is a natural polymer copolymer with abundant sources and low price. It is the only natural polysaccharide product with amino groups obtained by deacetylation of chitin, the second largest natural polysaccharide widely present in nature. N- Chitin with a degree of deacetylation higher than 60%. It has good biocompatibility, biodegradability, moisture absorption and moisturizing, antibacterial and film-forming properties, non-immunogenicity, non-inflammatory, non-toxic, and no harmful degradation products, making it a natural antibacterial agent one of the research hotspots. It meets the requirements of green environmental protection, making it one of the research hotspots in the development of natural moisturizers and antibacterial agents. The antibacterial properties of chitosa...

Claims

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Application Information

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IPC IPC(8): A61L12/14A61L101/50
Inventor 王怡红康丽红王军郭庆王亚强
Owner HAICHANG CONTACT LENSES
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