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Method for increasing content of chondroitin sulfate sodium

A technology of sodium chondroitin sulfate, content, applied in the field of biopharmaceuticals

Inactive Publication Date: 2014-03-26
QINGDAO JIULONG BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to meet this standard with traditional production techniques

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The following examples illustrate the invention in detail:

[0015] (1) Dissolution: 150Kg wet product (dry weight: 100Kg) was obtained after decolorization and precipitation of chondroitin sulfate sodium extract, and 300L purified water was added to dissolve;

[0016] (2) Heating: After adjusting the pH to 6.5, measure the volume of the solution to 400L, add 8Kg of sodium chloride, heat up to 55°C, and stir for 30 minutes;

[0017] (3) Thermal precipitation: maintain the temperature at 55°C, add 200L of 95% ethanol while stirring, and then cool down naturally;

[0018] (4) Collect the precipitate: when the temperature drops to 45°C, siphon the supernatant and collect the precipitate;

[0019] (5) The precipitate is dehydrated and dried to obtain a sodium chondroitin sulfate product with a content of 98.5% and a protein impurity limit of 1.6%.

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PUM

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Abstract

The invention relates to a method for increasing the content of chondroitin sulfate sodium. Chondroitin sulfate sodium is a mucopolysaccharide substance extracted from animal cartilages such as nasal bones of pigs and the like. The content of the chondroitin sulfate sodium product prepared by a traditional process is 90-95%, and the limit of protein impurities is above 5% while the European Pharmacopoeia stipulates that the content of chondroitin sulfate sodium is not lower than 95% and the limit of protein impurities is not higher than 3%. Visibly, the traditional process can not meet the requirements of the European Pharmacopoeia. In the method, the protein impurities in the chondroitin sulfate sodium product are removed by adopting a method of thermal precipitation. The process is reasonable, is high in removal efficiency, improves the product content and meets the requirements of the European Pharmacopoeia.

Description

technical field [0001] The field of the invention belongs to the field of biopharmaceuticals, and relates to a method for increasing the content of chondroitin sulfate sodium, in particular to a production process of chondroitin sulfate sodium. Background technique [0002] Chondroitin Sulfate Sodium is an acidic mucopolysaccharide extracted from animal tissue, which belongs to glycosaminoglycan. Clinically, it is mainly used for lipid-regulating drugs, arthritis, eye drops, etc. Sodium chondroitin sulfate is a relatively important biochemical drug currently on the market. It is included in the "Chinese Pharmacopoeia (2010 Edition)", and the content requirement is not less than 90%, and no protein limit is specified. However, the European Pharmacopoeia stipulates that the content of sodium chondroitin sulfate should not be lower than 95%, and the limit of protein impurities should not be higher than 3%. Traditional production techniques are difficult to meet this standard....

Claims

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Application Information

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IPC IPC(8): C08B37/08
Inventor 刘乃山夏衬来迟培升陆玉梅
Owner QINGDAO JIULONG BIO PHARMA
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