Method for purifying 1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyranose intermediate

A technology of trifluoromannose and purification method, applied in the field of purification of trifluoromannose intermediate, 1,3,4,6-tetraacetyl-β-D-mannose, can solve the problem of yield and purity. High, affecting the yield and purity of trifluoromannose, to achieve the effect of good stability and long shelf life
CN103739635AActive Publication Date: 2014-04-23无锡市江原实业技贸有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
无锡市江原实业技贸有限公司
Publication Date
2014-04-23

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Abstract

The invention provides a method for purifying a 1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyranose intermediate. The method comprises the following steps: adding a crude 1,3,4,6-tetraacetyl-beta-D-mannopyranose product into mixed liquid containing n-butyl alcohol and 2-methoxyethanol; heating the crude 1,3,4,6-tetraacetyl-beta-D-mannopyranose product until the crude 1,3,4,6-tetraacetyl-beta-D-mannopyranose product is dissolved; cooling the crude 1,3,4,6-tetraacetyl-beta-D-mannopyranose product until the crude 1,3,4,6-tetraacetyl-beta-D-mannopyranose product is completely crystallized; performing filtering, washing and drying to obtain the 1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyranose intermediate, namely a 1,3,4,6-tetraacetyl-beta-D-mannopyranose crystal. The yield and purity of the 1,3,4,6-tetraacetyl-beta-D-mannopyranose are remarkably improved, so that the problems of low yield and low purity of the synthesized 1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyranose intermediate namely 1,3,4,6-tetraacetyl-beta-D-mannopyranose in the prior art are solved.
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Description

technical field

[0001] The invention belongs to the field of separation and purification, and in particular relates to a method for purifying a trifluoromannose intermediate, that is, 1,3,4,6-tetraacetyl-β-D-mannose. Background technique

[0002] Trifluoromannose, whose chemical name is 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannose, is a synthetic PET imaging agent 18 Precursor of F-FDG. Currently, 18 F-FDG is the most widely used tracer in positron emission tomography (PET) imaging. It is not only widely used in laboratory research, but also widely used in daily clinical diagnosis of cardiovascular, neurological and tumor. Accounting for more than 90% of the clinical application of PET imaging, thus increasing the demand for mannose trifluoride, thus requiring higher requirements for the yield and purity of mannose trifluoride synthesized in the prior art to meet the three Huge demand for mannose.

[0003] At present, the industrial production of trifl...

Claims

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