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Type I collagen modified porous titanium coat and making method thereof

A technology of porous titanium and collagen, applied in medical science, prosthesis, etc., can solve the problems of easy desorption, limited collagen, instability, etc., and achieve the effects of good biological performance, good repeatability, and good fixation stability.

Active Publication Date: 2014-05-14
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the collagen fixed by physical adsorption is limited, unstable and easy to detach

Method used

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  • Type I collagen modified porous titanium coat and making method thereof
  • Type I collagen modified porous titanium coat and making method thereof
  • Type I collagen modified porous titanium coat and making method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0024] (1) Preparation of titanium coating: The titanium coating was prepared by plasma spraying technology.

[0025] (2) Alkali treatment: immerse the titanium coating in a NaOH solution with a concentration of 5-10M and keep it warm at 60-80°C for 6-12 hours. After taking it out, it can be cleaned with deionized water ultrasonically, and the ultrasonic cleaning can last for about 5 minutes. Here, 5-10M NaOH is used as the lye for alkali treatment, but it should be understood that other suitable lyes are also applicable, such as potassium hydroxide.

[0026] (3) Aging in deionized water: Soak the porous titanium coating obtained by alkali treatment in deionized water at 40-80°C for 3-7 days. The water can be changed once a day, and finally dried at 40°C.

[0027] (4) Silanization: Soak the dry porous titanium coating in a 5-10% aminopropyltriethoxysilane (APS) / toluene solution, heat the solution to boiling, condense and reflux, and react for 6-12 hours , after cooling, ultr...

Embodiment 1

[0031] [Preparation of modified titanium coating based on covalent bond immobilization of type I collagen]

[0032] The titanium coating (marked as TC) was prepared by plasma spraying technology. The prepared titanium coating was immersed in 5M NaOH solution, kept at 80°C for 12h, cleaned with deionized water ultrasonically, and aged in deionized water at 60°C. Leave for 7 days, change the water once a day, and dry at 40°C. The alkali-treated modified titanium coating is marked as TC-A. Soak the dried sample TC-A in a 10% APS / toluene solution, heat the solution to boiling, condense and reflux, and react for 12 hours. After cooling, it was ultrasonically cleaned once with alcohol and twice with deionized water, and dried in vacuum. Silanized titanium coatings are designated TC-AA. Soak the sample TC-AA in a solution with a concentration of 1 mg / mL type I collagen / 5 mM acetic acid. 1 mL of 120 mg / mL EDC aqueous solution and 1 mL of 30 mg / mL NHS aqueous solution were dropped ...

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Abstract

The invention relates to a type I collagen modified porous titanium coat and a making method thereof. The type I collagen modified porous titanium coat is obtained by fixing type I collagen to the surface of a porous titanium coat in a covalent bond grafting mode by adopting a biochemical modification process. Compared with physically-adsorbed collagen modified porous titanium coats, the covalent-grafted type I collagen modified porous titanium coat has the advantages of about 1 time increase of the fixed collagen amount, good fixing stability, reservation of above 90% after 7d, and good biological performances, and can be applied to promote bone implant materials inducing the growth of bone tissues. The making method has the advantages of simple technology, high efficiency and good repeatability, and provides a new method for medicinal biological coat technologies.

Description

technical field [0001] The invention relates to a type I collagen modified porous titanium coating and a preparation method thereof, in particular to a type I collagen fixed on the surface of a plasma sprayed titanium coating by means of covalent bond grafting and has good biological properties The type I collagen modified porous titanium coating and a preparation method thereof belong to the technical field of medical biological coatings. Background technique [0002] Titanium and titanium alloys are clinically commonly used bone implant materials. The porous titanium coating prepared on its surface by plasma spraying method is a common method to improve its combination with bone tissue. The porous structure can increase the mechanical fit between the bone and the surface of the implant, so that the bonding strength between the implant and the bone tissue can be significantly improved. Plasma-sprayed titanium-coated artificial joints and other hard tissue implants have be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/56
Inventor 敖海勇郑学斌汤亭亭谢有桃季衍黄利平
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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