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Method for improving hydrophilicity of polypeptide membrane by using polylactic acid and polyacrylic acid

A technology of polyacrylic acid and polylactic acid, which is applied in the field of polymer film preparation, to achieve the effect of simple operation, easy mastery and improved hydrophilicity

Inactive Publication Date: 2014-05-21
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the improvement of the hydrophilicity of polypeptide membranes by using polylactic acid and polyacrylic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0018] Add 20 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 60,000, 0.9 grams of 2,4-toluene diisocyanate and 285 ml of dimethyl sulfoxide solvent into the dry reactor, and add the above Dibutyltin dilaurate with a total weight of 3‰ of reactants, under an inert atmosphere, stirred and reacted at 40°C for 40 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;

[0019] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:

[0020] Add 15 g of poly(r-benzyl-L-glutamate) containing terminal -NCO groups, 11.8 g of polylactide monotetradecyl ether with a molecular weight of 3000, and 420 ml of dimethyl base sulfoxide solvent, then add dibutyltin dilaurate with a total weight of 3‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 40°C for 50 minutes, terminate the reaction, and obtain th...

Embodiment 2

[0025] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0026] Add 20 g of poly(r-ethyl-L-glutamate) with a molecular weight of 70,000, 1.02 g of 2,4-toluene diisocyanate, and 215 ml of dimethyl sulfoxide solvent into a dry reactor, and add the above reaction Dibutyltin dilaurate with a total weight of 4‰, under an inert atmosphere, stirred and reacted at 45°C for 45 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;

[0027] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:

[0028] Add 15 g of poly(r-ethyl-L-glutamate) containing terminal -NCO groups, 17.1 g of polylactide monotetradecyl ether with a molecular weight of 4000, and 410 ml of dimethyl sulfoxide solvent, and then add dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 45°C for 55 minutes, terminate the reaction, and obtain the target produc...

Embodiment 3

[0033] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0034] Add 20 g of poly(r-methyl-L-glutamate) with a molecular weight of 80,000, 0.96 g of 2,4-toluene diisocyanate, and 155 ml of dimethyl sulfoxide solvent into the dry reactor, and add the above reaction Dibutyltin dilaurate with a total weight of 5‰, under an inert atmosphere, stirred and reacted at 50°C for 50 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;

[0035] 2) Synthesis of polypeptide-polylactic acid diblock copolymer:

[0036] Add 15 g of poly(r-methyl-L-glutamate) containing terminal -NCO groups, 20.1 g of polylactide monotetradecyl ether with a molecular weight of 5000, and 352 ml of dimethyl sulfoxide solvent, and then add dibutyltin dilaurate with a total weight of 5‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 50°C for 60 minutes, terminate the reaction, and obtain the target pr...

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PUM

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Abstract

The invention discloses a method for improving the hydrophilicity of a polypeptide membrane by using polylactic acid and polyacrylic acid. The method comprises the following steps: (1) adding a polypeptide homopolymer, diisocyanate, a catalyst and a solvent into a dry reactor, reacting for 40-50 minutes at the temperature of 40-50 DEG C, and then, removing superfluous diisocyanate by a dialysis method, so as to obtain a polypeptide homopolymer containing terminal -NCO groups; (2) adding the polypeptide homopolymer containing terminal -NCO groups, a catalyst and a solvent into a dry reactor, then, adding polylactic-acid mono tetradecyl ether, and reacting for 50-60 minutes at the temperature of 40-50 DEG C, so as to obtain a polypeptide-polylactic acid diblock copolymer; (3) adding the polypeptide-polylactic acid diblock copolymer, polyacrylic acid and a solvent into a dry reactor, stirring and mixing for 60-70 minutes at the temperature of 40-50 DEG C, then, carrying out membrane forming by a tape casting method, and drying, thereby obtaining a target product of the method. According to the method, the preparation process is simple, and the hydrophilicity of the obtained modified membrane is improved greatly.

Description

technical field [0001] The invention relates to a method for improving the hydrophilicity of a polypeptide film, belonging to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a kind of biomaterial with biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the lack of good hydrophilicity of polypeptide film limits its application to a certain extent. Poly(D,L) lactic acid has good biocompatibility and biodegradability, is relatively soft and has good blendability with polyacrylic acid. Polyacrylic acid has good biocompatibility and biodegradability, and has excellent hydrophilicity. Firstly, the polylactic acid segment is introduced into the polypeptide segment to form a polypeptide-polylactic acid diblock copolymer to improve the blendability of the peptide, and then the polyacrylic acid segment is added to the polypeptide-polylactic acid diblock copolymer to form The blend was used t...

Claims

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Application Information

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IPC IPC(8): C08L87/00C08L33/02C08G81/00C08J5/18
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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