A method for improving the hydrophilicity of polypeptide membranes with polytrimethylene carbonate and polyvinylpyrrolidone

A technology of polytrimethylene carbonate and polyvinylpyrrolidone, which is applied in the field of polymer film preparation, can solve the problems of lack of hydrophilicity of the polypeptide film, and achieve the improvement of the hydrophilicity of the modified polypeptide film, which is easy to master and operate simple effect

Inactive Publication Date: 2016-01-20
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the lack of good hydrophilicity of polypeptide film limits its application to some extent. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Synthesis of polypeptide-polytrimethylene carbonate graft copolymer:

[0015] Add 12 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 60,000, 3.1 grams of polytrimethylene carbonate monolauryl ether with a molecular weight of 1000, and 0.9 grams of p-toluene in the dry reactor. Sulfonic acid, then add 260 ml of dimethyl sulfoxide solvent, under inert atmosphere, stir and react at 55°C for 3 days, terminate the reaction, and then obtain the target object by filtration, dialysis, and drying;

[0016] 2) Preparation of Polytrimethylene Carbonate and Polyvinylpyrrolidone Modified Polypeptide Film:

[0017] Add 10 grams of polypeptide-polytrimethylene carbonate graft copolymer and 38 ml of dimethyl sulfoxide solvent into the dry reactor, and add polyvinylpyrrolidone (molecular weight 4000) accounting for 1% of the total weight of the modified membrane , under an inert atmosphere, stirred and mixed at 40°C for 50 minutes, formed a film by casting method, and...

Embodiment 2

[0020] 1) Synthesis of polypeptide-polytrimethylene carbonate graft copolymer:

[0021] Add 12 grams of poly(r-ethyl-L-glutamate) with a molecular weight of 70,000, 5.3 grams of polytrimethylene carbonate monolauryl ether with a molecular weight of 1500, and 0.91 grams of p-toluenesulfonate in the dry reactor. acid, then add 230 ml of dimethyl sulfoxide solvent, under an inert atmosphere, stir and react at 56 ° C for 4 days, terminate the reaction, and then obtain the target object by filtration, dialysis, and drying;

[0022] 2) Preparation of Polytrimethylene Carbonate and Polyvinylpyrrolidone Modified Polypeptide Film:

[0023] Add 10 grams of polypeptide-polytrimethylene carbonate graft copolymer and 36 ml of dimethyl sulfoxide solvent into the drying reactor, and add polyvinylpyrrolidone (molecular weight 4500) accounting for 2% of the total weight of the modified membrane , under an inert atmosphere, stirred and mixed at 45°C for 60 minutes, formed a film by casting met...

Embodiment 3

[0026] 1) Synthesis of polypeptide-polytrimethylene carbonate graft copolymer:

[0027] Add 12 grams of poly(r-methyl-L-glutamate) with a molecular weight of 80,000, 7.2 grams of polytrimethylene carbonate monolauryl ether with a molecular weight of 2000, and 1.03 grams of p-toluenesulfonate in the dry reactor acid, then add 177 ml of dimethyl sulfoxide, under an inert atmosphere, stir and react at 58°C for 3 days, terminate the reaction, and then obtain the target product by filtration, dialysis, and drying;

[0028] 2) Preparation of Polytrimethylene Carbonate and Polyvinylpyrrolidone Modified Polypeptide Film:

[0029] Add 10 grams of polypeptide-polytrimethylene carbonate graft copolymer and 35.5 milliliters of dimethyl sulfoxide in the drying reactor, and add polyvinylpyrrolidone (molecular weight is 5000) accounting for 3% of the total weight of the modified membrane, Under an inert atmosphere, after stirring and mixing at 50°C for 70 minutes, a film was formed by casti...

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PUM

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Abstract

The invention discloses a method for improving the hydrophilicity of a polypeptide film by using polytrimethylene carbonate and polyvinylpyrrolidone. The following steps are adopted: 1) Synthesis of a graft copolymer of polytrimethylene carbonate-polytrimethylene carbonate: Add polypeptide homopolymer, polytrimethylene carbonate monododecyl ether, solvent and catalyst into the drying reactor, under inert atmosphere, stir and react at 55-58°C for 3-4 days, then filter, dialyze, Drying to obtain the target product; 2) Preparation of polytrimethylene carbonate and polyvinylpyrrolidone modified polypeptide film: add polypeptide-polytrimethylene carbonate graft copolymer, polyvinylpyrrolidone to the drying reactor and a solvent, under an inert atmosphere, stir and mix at 40-50°C for 50-70 minutes, then form a film by casting method and dry to obtain the object of the present invention. The preparation process of the invention is simple and easy to master, and the hydrophilicity of the obtained modified membrane is greatly improved.

Description

technical field [0001] The invention relates to a method for improving the hydrophilicity of a polypeptide film, belonging to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the lack of good hydrophilicity of polypeptide film limits its application to some extent. application. Polytrimethylene carbonate has better biocompatibility and biodegradability, and has better blendability with polyvinylpyrrolidone. Polyvinylpyrrolidone has good biocompatibility and biodegradability, and has excellent hydrophilicity. Firstly, the polytrimethylene carbonate segment is introduced into the polypeptide segment to form a polypeptide-polytrimethylene carbonate graft copolymer to improve the blendability of the polypeptide, and then the polyvinylpyrrolidone segment is added to the polypeptide- The polytrimethylene carbonate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L87/00C08L39/06C08G81/00C08J5/18
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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