Polymeric sorbent for removal of impurities from whole blood and blood products

A technology of blood products and sorbents, applied in blood diseases, medical raw materials derived from mammals, applications, etc., can solve problems such as blood shortages

Active Publication Date: 2014-05-28
CYTOSORBENTS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This situation, combined with the high demand for blood, has caused periodic blood shortages

Method used

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  • Polymeric sorbent for removal of impurities from whole blood and blood products
  • Polymeric sorbent for removal of impurities from whole blood and blood products
  • Polymeric sorbent for removal of impurities from whole blood and blood products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: overall synthetic method

[0041] In the search for neutrally buoyant beads, early experiments showed porous and solid beads of divinylbenzene-based polymers floating on packed red blood cells. Red blood cells (alone) have a density of 1.125 g / mL, while some of our divinylbenzene porous polymers have a backbone density of 1.082 g / mL. In practice, bags of packed red blood cells contain not only cells, but also substances such as preservatives (eg SAG), and residual plasma, which can cause the density of packed red blood cells to vary from bag to bag. The density of plasma is 1.025 g / mL. In our study, we found hematocrit values ​​of 40% to 60%. Interestingly, poly-4-chlorostyrene has a density of 1.55 g / mL. Therefore, consider that the copolymerization of divinylbenzene and 4-chlorostyrene at specific ratios will generate a series of neutrally buoyant beads in packed red blood cells. Such asfigure 1 It was shown that increasing the amount of 4-chlorostyr...

Embodiment 2～4

[0043] Embodiment 2~4: Sorbent synthesis

[0044] Three porous polymeric sorbents were characterized by their pore structure and their synthesis (described in Examples 2, 3 and 4). Structural characterization is given in Examples 5, 6 and 7. The polymers synthesized in these steps are then placed into suitable blood containers.

[0045] The synthesis procedure consists of (1) preparation of the aqueous phase, (2) preparation of the organic phase, (3) implementation of the suspension polymerization, (4) purification of the resulting porous polymer adsorbent product (work-up), and (5) adding a hemocompatible coating.

[0046] Reactor setup. 0.5 L kettle reactor equipped with an over-head stirrer with multi-level stirrer blade, water-cooled condenser, thermocouple, and bubbler (bubbler). A gasket was installed between the top cover and bottom kettle. All unused ports were capped with suitable stoppers. The temperature was controlled with a heating mantle regulated by a tem...

Embodiment 5

[0053] Embodiment 5: Pore structure characterization

[0054] The pore structure of the sorbent polymer was measured with Micromeritics AutoPore IV9500V1.09 Mercury Penetrometer (Mercury Penetrometer) (pressure Hg instrument) or Micromeritics ASAP2010 instrument (N 2 desorption) analysis to reveal the presence of large and small pores. The results are provided in Figure 4 and Figure 5 , where the pore volume is plotted as a function of pore diameter. Figure 7 It is shown in that different pore structures allow the polymer to sorb a range of different harmful by-products in blood.

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Abstract

The invention concerns methods of treating stored blood and blood products maximizing shelf life and / or minimizing transfusion related complications such as non not hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.

Description

[0001] related application [0002] This application claims the benefit of US Patent Application No. 61 / 523,170, filed August 12, 2011, the disclosure of which is incorporated herein in its entirety. technical field [0003] The present invention relates to compositions and methods useful for removing cytokines, bioactive lipids, free hemoglobin, membrane or cellular degradation products, inflammatory mediators, vasoactive substances, foreign antigens, and antibodies from blood and blood products. Background technique [0004] Transfusions of whole blood or derivatives of whole blood ("blood products") are truly a lifeline for patients ranging from severe trauma to cancer surgery. According to the American Red Cross, more than 14 million packed red blood cell (pRBC) transfusions are performed annually in the United States, and an average of 1 in 10 US hospital admissions requires a transfusion. Transfusions of other fractions of whole blood or blood products such as platele...

Claims

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Application Information

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IPC IPC(8): A01N1/02A61K35/14
CPCA01N1/021A61P7/08B01J20/267B01J20/28016B01J20/28073B01J20/28076B01J20/2808B01J20/28083B01J20/28085C08F236/20
Inventor 菲利普·P·哈恩文森特·J·卡波尼托马斯·D·戈洛比什胡迈拉·贝居姆·阿利
Owner CYTOSORBENTS CORP
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