Unlock instant, AI-driven research and patent intelligence for your innovation.
2-Arylselenazole compounds and medicinal composition thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A compound, the technology of selenazole, which is applied in the field of xanthine oxidase inhibitors to treat gout and hyperuricemia, 2-aryl selenazole compounds, can solve the problems of large toxic and side effects
Active Publication Date: 2014-06-11
NANJING LIFECARE PHARM CO LTD
View PDF13 Cites 9 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
As far as the chronic disease of gout is concerned, the design of new drugs targeting xanthine oxidase has received extensive attention, and a variety of highly active compounds have entered clinical trials, but they still face many problems such as high toxicity and side effects, and more in-depth research is needed. Research
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0145] Synthesis of 2-(3-cyano-4-ethoxyphenyl)-4-methyl-selenazole-5-carboxylic acid (6)
[0146]
[0147] Step A: Add absolute ethanol (540mL) dropwise to a mixture of seleniumpowder (50.0g, 0.633mol) and sodiumborohydride (26.4g, 0.698mol) within 3 to 4 hours under ice-water bath and nitrogen protection, After the addition was complete, the temperature was raised to room temperature and stirring was continued for 1 hour. Then add a pyridine solution (126mL) containing p-hydroxybenzonitrile (18.84g, 0.158mol), raise the temperature to reflux, then slowly add 2M hydrochloric acid solution (320mL) dropwise, and the dropwise addition time is not less than 4 hours, and reflux after the addition is completed. overnight. TLC analysis indicated that the reaction was complete. Most of the ethanol was evaporated under reduced pressure, diluted with water (400mL), extracted with ethyl acetate (200mL×2), the combined organic phase was washed with 2M hydrochloric acid (100mL), the...
Embodiment 2
[0156] Synthesis of 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-selenazole-5-carboxylic acid (7)
[0157]
[0158] For the experimental operation, see Step E and Step F in Example 1.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention discloses 2-arylselenazole compounds and a medicinal composition thereof. The 2-arylselenazole compounds are compounds represented by formula (I) or pharmaceutically acceptable salts thereof. The 2-arylselenazole compounds have a xanthine oxidase inhibition activity. The compounds or pharmaceutically acceptable salts thereof can be applied to prepare medicines for preventing or treating hyperuricemia, gout, diabetic nephropathy, inflammatory diseases and neurological system diseases.
Description
technical field [0001] The invention relates to a class of 2-aryl selenazole compounds and applications thereof, specifically belonging to the field of medicinal chemistry. The present invention also relates to the preparation method of these compounds, the pharmaceutical composition containing these compounds and their medical application, especially the application as xanthine oxidase inhibitor to treat gout and hyperuricemia. Background technique [0002] Gout is a disease caused by the excessive production of uric acid due to the disorder of purinemetabolism in the body, and the deposition of sodium urate in the body. Gout is the second most common metabolic disease after diabetes, and this disease has been listed by the United Nations as one of the twenty chronic diseases in the 21st century. Epidemiological studies at home and abroad have shown that with the improvement of human living standards and the extension of average human life expectancy, the incidence of hyp...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More 
