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Ergosterone, a monomer component of Phellinus phellifolia, its preparation method and its application in the preparation of antitumor drugs

A technology of ergosterone and monomer, which is applied in the field of medicine and achieves the effects of simple and easy preparation method, convenient operation and high extraction efficiency

Active Publication Date: 2016-05-25
安徽省森湶谷药业股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, in the prior art, there is no pharmacological report on the inhibition of various tumor cell lines by the compound ergosterone as an active ingredient

Method used

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  • Ergosterone, a monomer component of Phellinus phellifolia, its preparation method and its application in the preparation of antitumor drugs
  • Ergosterone, a monomer component of Phellinus phellifolia, its preparation method and its application in the preparation of antitumor drugs
  • Ergosterone, a monomer component of Phellinus phellifolia, its preparation method and its application in the preparation of antitumor drugs

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Experimental program
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Embodiment

[0027] The preparation method of Phellinus Phellinus monomer component ergosterone comprises the following steps:

[0028] (1) Take 10kg of dried Phellinus fruiting bodies, crush them, and reflux extract with 95% ethanol three times (6 times, 5 times, 4 times), each extraction for 2 hours, the extraction temperature is 80°C, filter, and combine The total extract was obtained from the three extractions; after recovering ethanol, it was concentrated under reduced pressure to an extract, added distilled water to make a suspension, and then extracted with petroleum ether, ethyl acetate, and n-butanol in sequence to obtain 65 g of petroleum ether extract, acetic acid Ethyl ester extract 462g, n-butanol extract 308g;

[0029] (2) 65g of petroleum ether extract was mixed with 200-300 mesh silica gel, and then the volume ratio of petroleum ether to ethyl acetate was 1:0, 100:1, 50:1, 30:1, 20:1, 10:1, 5:1, 0:1 were used as eluents, separated by silica gel column elution, and eight fr...

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Abstract

The invention discloses phellinus igniarius monomer component ergot ketosteroid and a preparation method and application thereof in preparation of anti-tumor drugs. The ergot ketosteroid is light yellow crystal with molecular formula C24H20O9 and melting point 113-115 DEG C; the ergot ketosteroid is easily dissolved in organic solvents such as chloroform, acetone, ethyl acetate and the like; the molecular structural formula is shown in the specification. In the invention, the monomer component ergot ketosteroid extracted from phellinus igniarius has a remarkable anti-cancer effect; moreover, the preparation method disclosed by the invention is simple and easy to implement and convenient to operate and realizes high extraction efficiency and stable product quality, thus the preparation method can be effectively used for preparing anti-tumor drugs.

Description

technical field [0001] The invention relates to ergosterone, a monomer component of Phellinus Phellinus, its preparation method and its application in the preparation of antitumor drugs, and belongs to the technical field of medicine. Background technique [0002] Tumor is a kind of common and frequently-occurring disease. It is a new organism formed by the abnormal growth and differentiation of clonal abnormal proliferation and differentiation due to gene mutation and loss of normal regulation of its growth and differentiation under the long-term action of various internal and external tumorigenic factors. or vegetation. Tumors are divided into benign tumors and malignant tumors, and malignant tumors are subdivided into three types: carcinoma derived from epithelial tissue, sarcoma derived from mesenchymal tissue, and carcinosarcoma. Usually people say "cancer" refers to all malignant tumors. [0003] Malignant tumor is one of the most important malignant diseases threate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00A61K31/575A61P35/00
Inventor 李宁孙靖龙方祥明王开金余春富
Owner 安徽省森湶谷药业股份有限公司