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Preparation method of polypeptide-poly trimethylene carbonate-MPEGPLA (mono-methoxyl poly(ethylene glycol)-poly(lactic acid) dual-graft copolymer

A technology of methyl carbonate and graft copolymer, which is applied in the field of biodegradable polymer material preparation, and achieves the effect of easy mastery and simple preparation method

Inactive Publication Date: 2014-06-18
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this double-graft copolymer has not been reported in the literature.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Graft Copolymer

[0016] Add 8 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 30000, 6.2 grams of polytrimethylene carbonate monotetradecyl ether with a molecular weight of 1500, and 1.2 grams of para Add toluenesulfonic acid, and then add 200 ml of 1,1,2-trichloroethane solvent, under an inert atmosphere, stir the reaction at 55°C for 3 days, terminate the reaction, and then obtain the target product by filtration, dialysis, and drying.

[0017] 2) Synthesis of Polypeptide-Polytrimethylene Carbonate-MPEGPLA Double Graft Copolymer:

[0018] Add 7 grams of polypeptide-polytrimethylene carbonate graft copolymer, 3.7 grams of MPEGPLA with a molecular weight of 1200 and 1.12 grams of p-toluenesulfonic acid in the dry reactor, and then add 143 milliliters of 1,1,2-trichloroethylene Alkanes solvent, under an inert atmosphere, stirred and reacted at 55°C for 3 days, terminated the reaction, and then filter...

Embodiment 2

[0021] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Graft Copolymer

[0022] Add 8 grams of poly(r-ethyl-L-glutamate) with a molecular weight of 35,000, 7.5 grams of polytrimethylene carbonate monotetradecyl ether with a molecular weight of 1700, and 1.31 grams of p-toluene in the dry reactor. Sulfonic acid and 181 ml of dimethyl sulfoxide solvent were stirred and reacted at 56° C. for 2 days under an inert atmosphere, and the reaction was terminated, followed by filtration, dialysis, and drying to obtain the target compound.

[0023] 2) Synthesis of Polypeptide-Polytrimethylene Carbonate-MPEGPLA Double Graft Copolymer:

[0024] Add 7 grams of polypeptide-polytrimethylene carbonate graft copolymer, 4.3 grams of MPEGPLA with a molecular weight of 1250 and 0.93 grams of p-toluenesulfonic acid in a dry reactor, then add 131 milliliters of dimethyl sulfoxide solvent, inert atmosphere Under 56°C, the reaction was stirred for 2 days, the reaction was terminated, and the t...

Embodiment 3

[0027] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Graft Copolymer

[0028] Add 9 grams of poly(r-methyl-L-glutamate) with a molecular weight of 40,000, 11 grams of polytrimethylene carbonate monotetradecyl ether with a molecular weight of 2000, and 1.35 grams of p-toluene in the dry reactor. Sulfonic acid and 250 ml of 1,1,2-trichloroethane solvent were stirred and reacted at 58° C. for 3 days under an inert atmosphere, and the reaction was terminated, followed by filtration, dialysis, and drying to obtain the target compound.

[0029] 2) Synthesis of Polypeptide-Polytrimethylene Carbonate-MPEGPLA Double Graft Copolymer

[0030] Add 8 grams of polypeptide-polytrimethylene carbonate graft copolymer, 5.5 grams of MPEGPLA with a molecular weight of 1300 and 1.07 grams of p-toluenesulfonic acid in the dry reactor, and then add 151 milliliters of 1,1,2-trichloroethylene Alkanes solvent, under an inert atmosphere, stirred and reacted at 58°C for 3 days, terminated the r...

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Abstract

The invention discloses a preparation method of a polypeptide-poly trimethylene carbonate-MPEGPLA (mono-methoxyl poly(ethylene glycol)-poly(lactic acid) dual-graft copolymer. The preparation method adopts the following steps: 1) adding a polypeptide homopolymer, poly trimethylene carbonate mono-tetradecyl ether, a solvent and a catalyst to a drying reactor, and stirring the materials at 55-58 DEG C to react for 2-3 days in the inert atmosphere, thus obtaining a polypeptide-poly trimethylene carbonate graft copolymer; 2) adding the polypeptide-poly trimethylene carbonate graft copolymer, the catalyst, the solvent and MPEGPLA to the drying reactor, and stirring the materials at 55-58 DEG C to react for 2-3 days in the inert atmosphere, thus obtaining the target object. The preparation method is simple in process, and the obtained target object is a novel degradable biological material.

Description

technical field [0001] The invention relates to a preparation method of a polypeptide-polytrimethylene carbonate-MPEGPLA double graft copolymer, belonging to the technical field of biodegradable polymer material preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability, which can be widely used in medicine as a carrier for the preparation of sustained-release drug systems; however, the polypeptide material is relatively hard and has poor hydrophilicity. As a result, its application is limited to a certain extent. Polytrimethylene carbonate has better biocompatibility and biodegradability, and is relatively soft. Monomethoxy polyethylene glycol polylactic acid (MPEGPLA) has excellent biocompatibility and biodegradability, and has good hydrophilicity. First graft the polytrimethylene carbonate segment to the polypeptide molecular chain to obtain the polypeptide-polytrimethylene carbonate graft copolymer, and then...

Claims

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Application Information

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IPC IPC(8): C08G81/00
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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