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Production method of biodegradable polymer support

A technology for degrading polymers and polymer materials, applied in the field of preparation of biodegradable polymer stents, can solve the problems of inability to slow down the physical aging of materials, the stent is prone to fracture, and the technical advantages are not obvious, and achieves improved strength and toughness, It is not easy to break, and the effect of reducing the breakage phenomenon

Inactive Publication Date: 2014-06-25
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after research, it was found that the technical advantages of the above-mentioned treatment effect are not obvious, and the physical aging of the material cannot be slowed down, and the stent treated by this method is still prone to fracture

Method used

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  • Production method of biodegradable polymer support
  • Production method of biodegradable polymer support
  • Production method of biodegradable polymer support

Examples

Experimental program
Comparison scheme
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preparation example Construction

[0043] The present invention generally provides a method for preparing a biodegradable polymer scaffold, comprising the following steps:

[0044] Step 1): preparing the biodegradable polymer original pipe 2 from the biodegradable polymer material;

[0045] Step 2): Put the original pipe material 2 prepared in the step 1) into the tubular mold 1 (such as figure 1 As shown, the original pipe material 2 is inserted into the inner hole of the tubular mold 1), the original pipe material 2 is heated, and high-pressure gas is injected into the original pipe material 2 to move along the radial direction of the original pipe material 2 Inflate the original pipe material 2 so that the outer diameter of the pipe material 3 after inflation is equal to the inner diameter of the tubular mold 1 (such as figure 2 shown), so that the tube can be highly oriented in the radial direction; and, the tube can be axially stretched along the axial direction of the tube before blowing the tube along ...

example 1

[0064] The polymer material of the original tubing 2 selected in this example is polylactic acid, a biodegradable polymer material. The polylactic acid particles were extruded to obtain a raw pipe 2 with an outer diameter of 1.5 mm and a wall thickness of 0.5 mm. Put this original pipe 2 into a stainless steel tubular mold 1 with an internal diameter of 2.5mm, such as figure 1 shown in . One end of the polylactic acid original pipe material 2 is closed, and the other end is connected with a high-pressure gas circuit. First, heat the original pipe 2 and the tubular mold 1 to raise the temperature to 120°C, then fill the original pipe 2 with high-pressure nitrogen at a pressure of 200 psi (pounds per square inch), and at the same time carry out axial Stretch, the stretching distance is 40mm. The original pipe 2 is prepared under the conditions of high temperature, high pressure and stretching into a pipe with an outer diameter of 2.5 mm and a wall thickness of 0.15 mm, that i...

example 2

[0069] The polymer material of the original pipe 2 selected in this example is polylactic-polyglycolic acid copolymer (PLGA), a biodegradable polymer material, with a copolymerization ratio of 85:15. The copolymerized particles were injection-molded to obtain an original pipe material 2 with an outer diameter of 1.2 mm and a wall thickness of 0.3 mm. This raw pipe material 2 was put into a stainless steel tubular mold 1 with an inner diameter of 2.5 mm. One end of the PLGA original pipe 2 is closed, and the other end is connected with a high-pressure gas circuit. First, the original pipe 2 and the tubular mold 1 are heated to 80° C., and then the original pipe 2 is filled with high-pressure helium at a pressure of 400 psi. The original pipe 2 was prepared under high temperature and high pressure conditions into a pipe with an outer diameter of 2.5 mm and a wall thickness of 0.15 mm. Afterwards, the entire system is rapidly cooled to 20° C., and then the pressure is released,...

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Abstract

The invention provides a production method of a biodegradable polymer support. The method includes 1, producing a biodegradable polymer original pipe through biodegradable polymer material; 2, placing the original pipe into a tubular die and heating, injecting high-pressure gas into the original pipe, allowing the original pipe to realize height orientation radially, and axially drawing the original pipe along the axial direction of the original pipe to realize simultaneously radial and axial orientation of the original pipe; 3, annealing the pipe, expanded by blowing, at the annealing temperature to obtain a formed pipe; 4, producing the biodegradable polymer support through the formed pipe. The annealing temperature is higher than the glass transition temperature of the polymer material and is lower than the melting temperature of the polymer material. The immediate support capacity of the support is high, breakage occurs rarely, the inner stress of the pipe can be released effectively, and accordingly service lives of the support and shelves can be prolonged.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable polymer bracket for medical use. Background technique [0002] As an important device for the treatment of vascular stenosis, stent has been widely used in the field of cardiovascular diseases. For metal stents that are widely used in clinical practice at present, because they will permanently remain in the human body after completing the treatment task, they will weaken MRI or CT images of coronary arteries, interfere with surgical revascularization, hinder the formation of collateral circulation, and inhibit the positive blood flow of blood vessels. Remodeling and other defects. Based on these problems, biodegradable scaffolds have attracted much attention as a possible alternative solution. [0003] Biodegradable stents are made of degradable polymer materials or metal materials. After being implanted in the lesion, the biodegradable stent can support blood vessels in a short period...

Claims

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Application Information

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IPC IPC(8): A61F2/91
CPCB29C49/0005B29C49/08B29K2995/006A61F2/82A61F2/91B29C49/04A61F2/90A61F2210/0004A61F2240/001B29C71/02B29C2071/022B29C71/0063B29C71/0072
Inventor 陈宝爱孟娟陈树国罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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