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Water-soluble carbon nanocomposite material for double phototherapy and its preparation method and application

A composite material and water-soluble technology, which is applied in the field of biomedical materials, can solve the problems of not fully exerting the photosensitivity of phthalocyanine, and the preparation method is complicated, and achieves the effects of enhanced killing efficiency and simple preparation method.

Active Publication Date: 2016-01-20
GUANGXI NORMAL UNIV
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  • Claims
  • Application Information

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Problems solved by technology

However, the preparation method is too complicated. In addition, the photosensitivity of phthalocyanine is not fully exerted by putting phthalocyanine into the interior of carbon nanohorns.

Method used

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  • Water-soluble carbon nanocomposite material for double phototherapy and its preparation method and application

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Experimental program
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Effect test

preparation Embodiment 1

[0027] The preparation of water-soluble single-walled carbon nanohorn-phthalocyanine complex, according to the following steps:

[0028] (1) Dissolve tetrasulfonic acid-based copper phthalocyanine with secondary water, prepare an aqueous solution with a mass concentration of 10%, and add single-wall Carbon nanohorns were ultrasonically ultrasonicated for 60 minutes.

[0029] (2) Centrifuge the ink-colored dispersion prepared above to remove large particle aggregates, filter the obtained liquid with a microporous membrane with a pore size of 220 nm, and wash with secondary water until the filtrate is colorless to remove free phthalocyanine. The obtained black solid was redispersed in water to obtain a single-wall carbon nanohorn-phthalocyanine complex with a total concentration of 1.4 mg / mL, of which phthalocyanine was 0.49 mg / mL and single-wall carbon nanohorn was 0.91 mg / mL .

[0030] The obtained single-wall carbon nanohorn-phthalocyanine composite can be uniformly dispers...

preparation Embodiment 2

[0032] The preparation of water-soluble single-walled carbon nanohorn-phthalocyanine complex, according to the following steps:

[0033] (1) Dissolve tetrasulfonate-based aluminum phthalocyanine with secondary water, prepare an aqueous solution with a mass concentration of 12%, and add single-wall Carbon nanohorns were ultrasonically ultrasonicated for 60 minutes.

[0034] (2) Centrifuge the above-prepared dispersion to remove large particle aggregates, filter the resulting liquid through a microporous membrane with a pore size of 220 nm, and wash with secondary water until the filtrate is colorless to remove free phthalocyanine. After drying, the single-walled carbon nanohorn-phthalocyanine composite is obtained.

preparation Embodiment 3

[0036] The preparation of water-soluble single-layer non-curled graphene-phthalocyanine composite, according to the following steps:

[0037] (1) Dissolve tetrasulfonic acid-based copper phthalocyanine with secondary water, prepare an aqueous solution with a mass concentration of 15%, and add a single layer of uncurled graphene, and ultrasonicated for 60 minutes with a sonicator.

[0038] (2) Centrifuge the above-prepared dispersion to remove large particle aggregates, filter the resulting liquid through a microporous membrane with a pore size of 200 nm, and wash with secondary water until the filtrate is colorless to remove free phthalocyanine. After drying, a single-layer uncurled graphene-phthalocyanine composite was obtained.

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Abstract

The water-soluble carbon nanocomposite material for dual phototherapy is a π-π planar conjugated complex composed of single-walled carbon nanohorns or single-layer uncurled graphene and water-soluble phthalocyanine. Its preparation method includes (1) dissolving water-soluble phthalocyanine with secondary water, preparing it to a mass concentration of 10% to 15%, adding single-walled carbon nanohorn or single-layer non-curling Graphene is ultrasonically ultrasonicated for 30 to 180 minutes; (2) centrifuge the above-prepared dispersion, filter it with suction, wash it, and dry it. Under the action of infrared light source, the composite material has dual therapeutic effects of photothermal and photodynamic, which enhances the killing efficiency of cancer cells; the preparation method is simple, and one-step ultrasonic method can solve the problem of single-walled carbon nanohorn or single-layer non-curled graphene. The water solubility of the carbon nanocomposite is loaded with photodynamic therapy agent, and the non-covalent modification is used, which does not destroy the surface characteristics of the carbon nanocomposite.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a phototherapy agent, more specifically to a dual phototherapy water-soluble carbon nanocomposite material and its preparation method and application. Background technique [0002] Phototherapy is a non-invasive treatment technology using visible light or near-infrared light irradiation. It has unique advantages such as remote controllability, high selectivity and low systemic toxicity. It has broad application prospects in the treatment of malignant tumors. Photothermal therapy and photodynamic therapy are two different forms of phototherapy currently widely used in tumor treatment. Photothermal therapy is the use of photothermal reagents to absorb light of specific wavelengths, and convert the absorbed energy into heat through non-radiative attenuation, resulting in an increase in local environmental temperature and irreversible damage to diseased cells. Photother...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/48A61P35/00
Inventor 沈星灿胡兰芳蒋邦平
Owner GUANGXI NORMAL UNIV
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