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Vegetable gum for preparing hollow capsules and hollow capsules thereof

A hollow capsule, plant-based technology, which is applied in the directions of capsule delivery, medical preparations with inactive ingredients, and applications, can solve the problems of low market share, long time limit for capsule disintegration, and difficulty in forming, and can achieve paste silk. The effect of shortening, reducing viscosity, and easy processing and molding

Active Publication Date: 2016-09-21
江苏崇尚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, the glue liquid material is relatively large in the production process of preparing hollow capsules, and it is difficult to remove water, and the glue paste thread is long and difficult to form. The capsules made of it as the main raw material have a long disintegration time limit, therefore, the current domestic market share is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 12wt% of hydroxypropyl methylcellulose (at 20°C, a concentration of 2wt% hydroxypropylmethylcellulose in aqueous solution has a viscosity of 7.0mpa s), 7wt% of acid-treated hydroxypropyl cassava Starch (degree of substitution DS=0.55, acid-treated hydroxypropyl tapioca starch is obtained by hydrochloric acid degradation and viscosity-reducing treatment of cassava starch, and then prepared with propylene oxide through a conventional reaction method in the starch industry), 0.4wt% konjac gum and The rest of the water is mixed to obtain the plant gum for preparing the hollow capsule.

[0018] The hydroxypropyl methylcellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared hydroxypropyl methylcellulose hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and...

Embodiment 2

[0020] 22wt% of hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 3.0mpa·s), 3wt% of hydroxypropyl wheat starch (substituted Degree DS=0.08, hydroxypropyl wheat starch is prepared by wheat starch and propylene oxide through the conventional reaction mode of starch industry), 2wt% carrageenan and the rest of the water are mixed to obtain the vegetable gum for preparing hollow capsules .

[0021] The hydroxypropyl methylcellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared hydroxypropyl methylcellulose hollow capsules refer to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and the disintegration experiment is carried out by using Tianda Tianfa ZB-1E intelligent disintegration instrument, and all 50 samples can be disintegrated within 6 minu...

Embodiment 3

[0023] With 25wt% hydroxypropyl methylcellulose (at 20°C, a concentration of 2wt% hydroxypropylmethylcellulose solution has a viscosity of 3.0mpa·s), 0.1wt% hydroxypropyl cornstarch ( The degree of substitution DS=0.004, hydroxypropyl cornstarch is prepared by cornstarch and propylene oxide through the conventional reaction mode of starch industry), 1wt% locust bean gum and the rest of the water are mixed to obtain the plant for preparing hollow capsules Glue.

[0024] The hydroxypropyl methylcellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared hydroxypropyl methylcellulose hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and the disintegration experiment was carried out by using Tianda Tianfa ZB-1E intelligent disintegration instrument, and all 50 samp...

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Abstract

The invention relates to a plant gum used for manufacturing hollow capsules used for food, medicine, etc., and a rapidly disintegrating hollow capsule prepared from the plant gum. The present invention mixes 12-25wt% of hydroxypropyl methylcellulose, 0.1-9wt% of hydroxypropyl starch or acid-treated hydroxypropyl starch, 0.4-2wt% of gelling agent and the rest of the water, That is, the vegetable gum used for preparing the hollow capsule is prepared. For the hydroxypropyl methylcellulose, at 20°C, the aqueous solution with a concentration of 2wt% hydroxypropyl methylcellulose has a viscosity of 3 to 7mpa·s; the hydroxypropyl starch or acid-treated The degree of substitution DS of hydroxypropyl starch is in the range of 0.004-0.55. The vegetable gum used for preparing the hollow capsules of the present invention can be prepared by adopting a conventional capsule preparation process to prepare rapidly disintegrating hydroxypropyl methylcellulose hollow capsules.

Description

technical field [0001] The invention relates to a plant gum used for manufacturing hollow capsules used for food, medicine, etc., and a rapidly disintegrating hollow capsule prepared from the plant gum. Background technique [0002] Capsules made from animal-derived gelatin have been around for at least 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident that broke out in my country undoubtedly aggravated the distrust of the Chinese people towards gelatin capsules. In addition, gelatin capsules themselves h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A23P10/30
Inventor 闫丰文袁国卿
Owner 江苏崇尚生物科技有限公司