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Composition containing bupivacaine for local anaesthesia and application thereof

A bupivacaine and local anesthesia technology, applied in the field of medicine, can solve the problems of long recovery time, unstable hemodynamics, complete motor nerve block, etc., and achieve the effect of improving safety and accuracy

Inactive Publication Date: 2014-07-23
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the conventional dose (15mg) of bupivacaine is used for spinal anesthesia, although it can produce satisfactory labor pain effect, it also has the disadvantages of hemodynamic instability, complete motor nerve block and long recovery time.

Method used

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  • Composition containing bupivacaine for local anaesthesia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Preparation of freeze-dried powder injection of anesthesia composition

[0022] Bupivacaine: 3.0mg,

[0023] Sufentanil: 1 mu g;

[0024] Corydalin: 30 mu g;

[0025] Indomethacin: 15 mu g;

[0026] Ropivacaine: 0.1mg

[0027] Dissolve the corresponding anesthetic composition components and 100 mg glucose in water for injection according to the prescription amount, add activated carbon for adsorption, decarbonize and filter, 0.22 mu M microporous membrane filtration, the obtained filtrate is then divided into sterile vials according to the aforementioned dosage specifications under aseptic conditions, and freeze-dried in a vacuum to obtain a freeze-dried powder; then seal the ampoule with a plastic aluminum cap vial , labeling, and ethylene oxide sterilization to obtain the freeze-dried powder injection.

[0028] The vacuum freeze-drying method is as follows: 1. Quickly freeze and pre-freeze for 2 hours at an ultra-low temperature of -40°C to -60°C t...

Embodiment 2

[0030] Example 2 Preparation of freeze-dried powder injection of anesthesia composition

[0031] Bupivacaine: 3.0mg,

[0032] Sufentanil: 3 mu g;

[0033] Corydalin: 20 mu g;

[0034] Indomethacin: 20 mu g;

[0035] Ropivacaine: 0.3mg

[0036] Dissolve the corresponding anesthetic composition components and 100 mg glucose in water for injection according to the prescription amount, add activated carbon for adsorption, decarbonize and filter, 0.22 mu M microporous membrane filtration, the obtained filtrate is then divided into sterile vials according to the aforementioned dosage specifications under aseptic conditions, and freeze-dried in a vacuum to obtain a freeze-dried powder; then seal the ampoule with a plastic aluminum cap vial , labeled to obtain the freeze-dried powder injection.

[0037] The vacuum freeze-drying method is as follows: 1. Quickly freeze and pre-freeze for 2 hours at an ultra-low temperature of -40°C to -60°C to form fine crystals; 2. Then heat ...

Embodiment 3

[0039] Example 3 Research on the Anesthesia Effect of the Freeze-Dried Powder Injection Prepared in Examples 1 and 2

[0040] A total of 160 elderly patients undergoing surgery on the lower abdomen and lower limbs were collected and randomly divided into 4 groups, aged 61-83 years, weighing 49-75kg, ASA I-II, without coagulation dysfunction, lower limb motor dysfunction and vomiting Medical history, type of operation: urethral resection of prostate or bladder tumor resection, internal fixation of lower extremity fractures, etc. (all operations were completed within 75 minutes).

[0041] The patient fasted for 8 hours before the operation, lay down and connected to the monitoring equipment, and recorded the basic value. The patient was placed in the lateral position and underwent joint hard-spinal puncture in the L3-4 space. After success, anesthesia was injected into the subarachnoid space at a main speed of about 20 seconds. After anesthesia, all patients routinely inhaled...

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PUM

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Abstract

The invention relates to the field of medicines, and particularly relates to a pharmaceutical composition which has anesthetic action in operation. The composition is prepared from 1.0-3.0mg of bupivacaine, 1-5mu g of sufentanil, 15-30mu g of tetrahydropalmatine, 15-30 mu g of indometacin and 0.1-0.5mg of ropivacaine. The anesthetic composition is preferably prepared from 3.0mg of bupivacaine, 3mu g of sufentanil, 20mu g of tetrahydropalmatine, 20mu g of indometacin and 0.3mg of ropivacaine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine composition with anesthesia effect in operation. Background technique [0002] With the improvement of living standards, my country has gradually entered an aging society, and the proportion of elderly patients among surgical patients is gradually increasing. In China, most lower abdomen and lower extremity operations are performed under spinal anesthesia. The use of spinal anesthesia in elderly patients can improve the success rate of anesthesia and reduce the incidence of block insufficiency. [0003] However, due to the decline of organ function, the stress ability of elderly patients is poor, and some of them are in a state of tension and anxiety. They often cannot bear the strong stimulation brought by surgical trauma, and the regulation function of their autonomic nervous system declines. Sudden deterioration or even accidents. Therefore, under spinal anesthesia and epi...

Claims

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Application Information

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IPC IPC(8): A61K31/4535A61P23/02A61K31/445A61K31/4375A61K31/405
Inventor 王寿世宋婷婷杨诚
Owner QINGDAO CENT HOSPITAL
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