27 results about "Narcotic Effects" patented technology

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a pharmaceutical use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has high-efficiency sedative, hypnotic and / or anesthetic effects, can control status epilepticus, and also has an analgesic effect, providing a new choice for clinical preparation of a drug having the analgesic effect, a drug having the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having both the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus and also having the analgesic effect.

A substituted phenol derivative and the use thereof, which relates to the field of medicinal chemistry. The substituted phenol derivative is a compound represented by formula I, or a stereoisomer, a pharmaceutically acceptable salt, a solvate, a prodrug, a metabolite, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and / or anesthetic effects, but also has an analgesic effect. The derivative can control status epilepticus, and has good safety during use. Therefore, the derivative has broad application prospects in the preparation of a drug having both sedative, hypnotic and / or anesthetic effects and an analgesic effect and capable of controlling status epilepticus, and provides a new option for the clinical preparation of a drug having both an analgesic effect and sedative, hypnotic and / or anesthetic effects, which is capable of controlling status epilepticus, etc.

Disclosed in the present invention are a benzodiazepine compound, a pharmaceutical composition and the use thereof. Specifically provided is a compound represented by formula I, or a stereoisomer thereof, a deuterated compound thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present invention has one or more of the following advantageous effects: (1) the compound of the present invention exhibits good intravenous sedative and anesthetic effects; (2) the compound of the present invention exhibits low drug accumulation and a good tolerance; and (3) the compound of the present invention achieves an anesthetic effect with faster recovery.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has efficient sedative, hypnotic and / or anesthetic effects, can control the status epilepticus, further has an analgesic effect, and provides a new option for clinically preparing a drug having an analgesic effect, a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus, and a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus and also having the analgesic effect.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The invention discloses substituted phenol derivatives and application thereof, and relates to the field of medicinal chemistry. The substituted phenol derivative is a compound as shown in a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and / or anesthetic effects, but also has an analgesic effect, can control the state of epilepsy, and is good in safety during use. Therefore, the derivative has wide application prospects in preparation of drugs which have sedative, hypnotic and / or anesthetic effects and analgesic effects and can control the epileptic status. The invention provides a new choice for clinically preparing medicines which have the effects of easing pain, calming, hypnotizing and / or anesthetizing, controlling the epileptic status and the like. # imgabs0 #

Abstract: A piperazine-substituted phenol derivative having the structure represented by formula (I) is provided. This compound not only has good salt-forming properties and excellent water solubility to meet pharmaceutical requirements, but also has a low minimum effective dose of anesthetics, rapid onset of action, and rapid recovery. This overcomes the drawbacks of prodrugs and lipid emulsion formulations of propofol and ciprofol, and is expected to be used in the preparation of drugs with sedative, hypnotic, and / or anesthetic effects and drugs for controlling status epilepticus. TIFF2025535407000076.tif41170

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

Provided in the present invention are heterocyclic compounds, and a pharmaceutical composition and use thereof, belonging to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the present invention have effective sedative, hypnotic and / or anaesthetic effects, can control the status epilepticus, and also have an analgesic effect, thus providing a new option for clinical preparation of drugs having an analgesic effect, drugs having anaesthetic, sedative, or hypnotic effects and / or capable of controlling status epilepticus, and drugs having anaesthetic, sedative, or hypnotic effects and / or being capable of controlling status epilepticus and also having an analgesic effect.

Provided in the present invention are a heterocyclic compound and the use thereof, belonging to the technical field of pharmaceutical chemistry. A series of heterocyclic compounds prepared in the present invention have highly efficient sedative, hypnotic, and / or anesthetic effects, can control status epilepticus, and also have analgesic effects, thus providing a new option for the clinical preparation of a drug having analgesic effects, a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus which also has analgesic effects.

The present invention belongs to the technical field of medicine. Provided are a compound, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula I. The compound of the present invention not only has efficient sedative, hypnotic and / or anesthetic effects, and the ability to control status epilepticus, but also exhibits an analgesic effect, and can reduce or avoid the use of opioid analgesics such as fentanyl, alfentanil, sufentanil or remifentanil in clinical application, thereby reducing the occurrence of adverse reactions such as circulatory depression, respiratory depression, urinary retention and pruritus caused by opioid analgesics.

The invention provides a heterocyclic compound and application thereof, and belongs to the technical field of medicinal chemistry. The structure of the heterocyclic compound is shown as a formula II. The compound provided by the invention has efficient sedation, hypnosis and / or anesthesia effects, can control the state of epilepsy, also has an analgesic effect, and has great significance for clinically preparing drugs with the analgesic effect, drugs with anesthesia, sedation and hypnosis effects and / or drugs capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The present application relates to the technical field of inhalation anesthetic antagonism, and particularly relates to the application of a corticotropin-releasing hormone receptor antagonist in the preparation of an inhalation anesthetic antagonist. The present application first discovers that the corticotropin-releasing hormone receptor of the dorsal raphe nucleus is a key target of the action of an inhalation anesthetic, and that the oculomotor nerve parvocellular nucleus-dorsal raphe nucleus neural loop mediates the effect of an inhalation anesthetic, and that a corticotropin-releasing hormone receptor antagonist can block the excitatory effect of urocortin on the neurons of the dorsal raphe nucleus, thereby weakening the effect of an inhalation anesthetic. The present application first applies a corticotropin-releasing hormone receptor antagonist in the preparation of an inhalation anesthetic antagonist, fills the technical gap in this field, is conducive to the rapid postoperative recovery of patients under general anesthesia, and has a broad application prospect.

The invention provides a heterocyclic compound and pharmaceutical application thereof, and belongs to the technical field of medicinal chemistry. The structure of the heterocyclic compound is shown as a formula II. The compound provided by the invention has efficient sedation, hypnosis and / or anesthesia effects, can control the state of epilepsy, also has an analgesic effect, and has great significance for clinically preparing drugs with the analgesic effect, drugs with anesthesia, sedation and hypnosis effects and / or drugs capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The present invention belongs to the technical field of medicine. Provided are a compound, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula I. The compound of the present invention not only has efficient sedative, hypnotic and / or anesthetic effects, and can control status epilepticus, but also has an analgesic effect, and can reduce or avoid the use of opioid analgesics such as fentanyl, alfentanil, sufentanil or remifentanil in clinical application, thereby reducing the occurrence of adverse reactions such as circulatory inhibition, respiratory inhibition, urinary retention and pruritus caused by opioid analgesics.

The present invention relates to the field of pharmaceutical chemistry. Provided are a quaternary ammonium salt compound containing a bridged ring structure, and a preparation method therefor and the use thereof. The compound has a structure as shown in formula (I). The compound can not only produce a long-acting analgesic effect, but also has a low toxicity to systemic and local tissues, has a good safety and a long duration of action in use, and has broad application prospects in the preparation of drugs having long-acting analgesic and / or long-acting local anesthetic effects.

A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, a metabolite thereof or a deuterated derivative thereof. The substituted nitrogen heterocyclic compound provided in the present application has good central nervous system inhibition effects, capable of generating sedative, hypnotic and / or general anesthetic effects, and capable of controlling status epilepticus; said substituted nitrogen heterocyclic compound is also characterized by rapid onset of action and rapid recovery, while maintaining positive anesthetic activity; in addition, said substituted nitrogen heterocyclic compound has almost no inhibitory effect on adrenocortical function, low side effects, and resolves technical difficulties in the art. The present invention provides a new selection for clinical screening and / or preparation of sedative, hypnotic and / or general anesthetic drugs and drugs controlling status epilepticus.

This invention discloses an N-acetanilide cationic compound, its preparation method, and its applications, particularly in the pharmaceutical field. This cationic compound exhibits rapid onset of action, high potency, long duration of action, good safety profile, and strong nerve-blocking effect. It can exert a reversible and sustained local anesthetic effect in vivo and can be used as a long-acting and / or selectively blocking local anesthetic or analgesic, showing great promise and value.

The invention relates to a novel pyrimidine derivative and application thereof. Specifically, the invention relates to a compound as shown in a formula I, a preparation method of the compound, a pharmaceutical composition and a combined product containing the compound, and application of the compound, the pharmaceutical composition or the combined product in preparation of central inhibitory drugs with sedative hypnotic and / or anesthetic effects,

The invention discloses a benzodinitrogen compound, a pharmaceutical composition and application of the benzodinitrogen compound. Specifically provided are a compound represented by formula I, and a stereoisomer, a deuterated compound or a pharmaceutically acceptable salt thereof. The compound provided by the invention has one or more advantages and effects as follows: (1) the compound provided by the invention has a relatively good vein sedation and anesthesia effect; (2) the compound provided by the invention is small in drug accumulation effect and good in tolerance; and (3) the compound disclosed by the invention has an anesthetic effect of more quickly reviving.

The invention belongs to the technical field of medicine synthesis and application, and particularly relates to an etomidate derivative and a preparation method and application thereof. Compared with etomidate, the compounds as shown in the formulas I and II or the isomers thereof provided by the invention partially have better anesthetic effect and more excellent effective dose, and are drugs capable of being used in the aspect of anesthesia.

The invention provides a heterocyclic compound and application thereof, and belongs to the technical field of medicinal chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The application provides a preparation method of lidocaine-containing polycaprolactone microsphere injection, and belongs to the technical field of facial filler preparation; the preparation process comprises the following steps: preparing modified gelatin hydrogel; preparing sustained-release antibacterial gel; preparing polycaprolactone microspheres; and preparing polycaprolactone microsphere injection. According to the application, lidocaine is added into the polycaprolactone microspheres, so that the lidocaine plays a role of anesthesia after people inject the polycaprolactone microsphere injection; the lidocaine can inhibit the generation and conduction of nerve impulses, leads to loss of sensation or numbness, and realizes the effect of local anesthesia, so that the pain of the patient can be relieved without additional use of anesthetics.

The present invention relates to the technical field of medicinal chemistry, and specifically discloses a compound or composition and its application in the preparation of anesthetic drugs. The compound selected is solamargine or andrographolide. The composition contains solamargine and andrographolide. Since solamargine or andrographolide has a certain anesthetic effect; therefore, using solamargine or andrographolide as an active ingredient in the preparation of anesthetic drugs has important application value; in addition, when the weight ratio of solamargine and andrographolide is controlled within the range of 1-5:1-5, the anesthetic effect of the obtained composition is significantly higher than that of single solamargine or andrographolide, and a synergistic effect can be produced, having a more excellent anesthetic effect; therefore, compared with using single solamargine or andrographolide, using the composition of the present invention is beneficial to reducing the dosage of anesthetic drugs.

The invention provides a quaternary ammonium salt compound containing a bridge ring structure as well as a preparation method and application thereof, and relates to the field of medicinal chemistry. The structure of the compound is shown as a formula I in the specification. The compound provided by the invention not only can generate a long-time analgesic effect, but also has low toxicity to whole body and local tissues, is good in safety and long in acting time during use, and has a wide application prospect in preparation of medicines with long-acting analgesic or / and long-acting local anesthesia effects.