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Vegetable gum for preparing hollow capsules and its application

A hollow capsule and plant-based technology, applied in the field of plant-based glue, can solve the problems of large glue liquid, long glue paste filaments, and difficult molding, and achieve the effects of accelerating dissolution speed, improving production efficiency, and easy molding

Active Publication Date: 2016-05-11
青岛盛海海洋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, the glue liquid material is relatively large in the production process of preparing hollow capsules, and it is difficult to remove water, and the glue paste thread is long and difficult to form. The capsules made of it as the main raw material have a long disintegration time limit, therefore, the current domestic market share is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 12wt% hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 7.0mpa s), 7wt% starch octenyl succinate (degree of substitution DS=0.005), 0.4wt% konjac gum and the rest of water were mixed to obtain vegetable gum for preparing hollow capsules.

[0016] The cellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared cellulose hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. Tianda Tianfa ZB-1E intelligent disintegration instrument was used for disintegration experiments. All 50 samples were tested and all disintegrated within 6 minutes. The disintegration time limit meets the requirements of the Pharmacopoeia.

Embodiment 2

[0018] 22wt% hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 3.0mpa s), 3wt% starch octenyl succinate (degree of substitution DS=0.02), 2wt% carrageenan and the rest of water were mixed to obtain vegetable gum for preparing hollow capsules.

[0019] The cellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared cellulose hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. Tianda Tianfa ZB-1E intelligent disintegration instrument was used for disintegration experiments. All 50 samples were tested and all disintegrated within 6 minutes. The disintegration time limit meets the requirements of the Pharmacopoeia.

Embodiment 3

[0021] 25wt% hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 3.0mpa s), 0.5wt% octenyl succinic acid starch Esters (substitution degree DS=0.01), 1wt% locust bean gum and the rest of water were mixed to obtain vegetable gum for preparing hollow capsules.

[0022] The cellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared cellulose hard hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and the Tianda Tianfa ZB-1E intelligent disintegration instrument was used for disintegration experiments. All 50 samples were tested and all disintegrated within 8 minutes. Its disintegration time limit meets the requirements of the Pharmacopoeia.

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Abstract

The invention relates to vegetable jelly for preparing hollow capsules, and applications of the vegetable jelly. The vegetable jelly comprises the following active ingredients in percentage by weight: 12-25% of hydroxypropyl methylcellulose, 1-7% of starch octenylsuccinate, 0.4-2% of gelatinizing agent, and the balance of water; the viscosity of a 2wt% hydroxypropyl methylcellulose water solution is 3-7mpa.s at 20 DEG C; the degree of substitution DS of the starch octenylsuccinate is within the range of 0.005-0.02. Through adopting the method of adding the starch octenylsuccinate into a cellulose matrix to modify the hydroxypropyl methylcellulose matrix, the paste silks of mixed components are shorter, and easy to form, and the production efficiency can be improved; the compact structure of the cellulose hollow capsules in a dissolving process can be effectively broken, the dissolving velocity of the hydroxypropyl methylcellulose cellulose matrix can be quickened, the disintegration of the hollow capsules can be promoted and drug release can be quickened.

Description

technical field [0001] The present invention relates to the plant gum used for preparing hollow capsules for food, medicine, etc., and the application of the plant gum used for preparing hollow capsules. Background technique [0002] Capsules made from animal-derived gelatin have been around for at least 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident that broke out in my country undoubtedly aggravated the distrust of the Chinese people towards gelatin capsules. In addition, gelatin capsules themselves ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K9/48A23P10/30
Inventor 闫丰文袁国卿
Owner 青岛盛海海洋生物科技有限公司