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A traditional Chinese medicine material composition with antidepressant effect and its preparation method and application

An antidepressant and drug technology, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve problems such as research reports on depression diseases that have not been seen with compositions.

Active Publication Date: 2021-04-16
石任兵 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the purification and preparation of antidepressant drug substance combination from Yuanzhi Decoction, and there is no relevant research report on the composition in the treatment of depression

Method used

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  • A traditional Chinese medicine material composition with antidepressant effect and its preparation method and application
  • A traditional Chinese medicine material composition with antidepressant effect and its preparation method and application
  • A traditional Chinese medicine material composition with antidepressant effect and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0026] Experimental example 1 The improvement effect of the rat olfactory bulb damage model caused by the antidepressant active part of the present invention

[0027] (1) Experimental materials

[0028] 1. Experimental animals

[0029] SD rats, male, weighing 230-250g. Provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0030] 2. Drugs and reagents

[0031] Drugs under test: antidepressant active fraction of Yuanzhi Decoction (mixture of active ingredients); Fluoxetine Hydrochloride Dispersible Tablets, production batch number: 0745A.

[0032] 3. Equipment

[0033] Rat brain stereotaxic instrument, electric soldering iron, etc.

[0034] (2) Experimental methods and results

[0035] 1. Grouping and administration

[0036] After feeding for 1 week, the rats were divided into 5 groups: blank control group, sham operation group and model group. The olfactory bulb was damaged in the model group, and the sham operation group was the same as the model...

Embodiment 1

[0050] Embodiment 1: Capsules

[0051] Polygala 500g Shichangpu 500g

[0052] Take 500g of raw material Polygala decoction pieces according to the above ratio, reflux extraction with 60% ethanol 4L for 3 times, extract for 1.5 hours each time, reclaim the solvent under reduced pressure, and obtain the extract; add water to disperse and dissolve, so that the concentration of the aqueous solution is 0.1g / mL Medicinal material volume meter, wherein the concentration of terpene is 6.453mg / ml, the concentration of total phenols is 5.953mg / ml), through DM130 macroporous adsorption resin, the ratio of resin diameter to height is 1:6; the ratio of sample amount to resin volume is 1:8, The adsorption flow rate is 3BV / h, and the impurity is removed by washing with 2 times the column volume, and the impurity removal flow rate is 3BV / h. 30% alcohol was eluted with 5 times the column volume at 3BV / h, the solvent was recovered, and dried under reduced pressure to obtain the effective compo...

Embodiment 2

[0080] Embodiment 2: tablet

[0081] Polygala 500g Shichangpu 500g

[0082] Take 500g of raw material Polygala decoction pieces according to the above ratio, reflux extraction with 70% ethanol 4L for 3 times, extract for 1.5 hours each time, reclaim the solvent under reduced pressure, and obtain the extract; add water to disperse and dissolve, so that the concentration of the aqueous solution is 0.1g / mL Medicinal material volume meter, wherein the concentration of terpene is 6.453mg / ml, the concentration of total phenols is 5.953mg / ml), through DM130 macroporous adsorption resin, the ratio of resin diameter to height is 1:6; the ratio of sample amount to resin volume is 1:8, The adsorption flow rate is 3BV / h, and the impurity is removed by washing with 2 times the column volume, and the impurity removal flow rate is 3BV / h. 30% alcohol was eluted with 5 times the column volume at 3BV / h, the solvent was recovered, and dried under reduced pressure to obtain the effective compone...

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Abstract

The invention belongs to the field of drug research and development, and relates to a drug substance, in particular to a drug substance with antidepressant effect and a preparation method thereof. It is obtained from Polygala Decoction through ethanol extraction and macroporous adsorption resin purification, which enriches the phenolic acid components, terpenoid components, and phenylpropanoid components in Polygala Decoction, and is proved by rat olfactory bulb damage and depression model tests. The pharmaceutical composition can increase the content of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the hippocampal region of the rat brain, thereby achieving the purpose of antidepressant.

Description

technical field [0001] The invention belongs to the field of drug research and development, and relates to a drug substance, in particular to a drug substance with antidepressant effect and a preparation method thereof. Background technique [0002] Depression is one of the most common mental illnesses. With the acceleration of modern life and work rhythm and the increase of various stress factors, people's psychological pressure is gradually increasing, and the number of depression patients in society is increasing day by day. The etiology of depression is complex and has not yet been fully elucidated. Although some western medicines such as clomipramine, fluoxetine, venlafaxine, and mirtazapine have certain therapeutic effects on depression, they still have narrow antidepressant spectrum, many adverse reactions, easy drug resistance and high price. Expensive and other defects. [0003] Polygala decoction is commonly used as a clinical antidote, which has the effects of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61P25/24A61P31/04A61P29/00A61P11/14A61P11/10
Inventor 石任兵王永炎张璐李焕娟彭平姜艳艳朱乃亮
Owner 石任兵
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