Application of D-erythro-Sphingosine in central nervous system

A sphingosine and myelin technology, which can be used in nervous system cells, nervous system diseases, vertebrate cells, etc., and can solve problems such as unclear downstream signal transduction pathways.
CN103992985AInactive Publication Date: 2014-08-20SHANGHAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI UNIV
Publication Date
2014-08-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an application of a compound D-erythro-Sphingosine (DES) in a central nervous system. During the multiple sclerosis disease course, many inhibitory factors are generated in disintegrated axon myelin. These inhibitory factors inhibit differentiation and maturation and remyelination of newborn oligodendrocytes. It proves through results of compound screening that DES can relieve inhibition of myelin debris on differentiation and maturation of newborn oligodendrocytes and promote recovery of EAE demyelination mouse athletic ability. Thus, it prompts that the compound can be used for treating demyelination disease of the central nervous system.
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Description

technical field

[0001] The invention relates to the application of a compound sphingosine (D-erythro-Sphingosine, DES) in the central nervous system. Background technique

[0002] In the pathogenesis of central nervous system demyelinating diseases such as multiple sclerosis, it is accompanied by the differentiation, maturation and remyelination of OPC cells. At present, the research on the molecular mechanism of how to promote the process of remyelination in patients with multiple sclerosis is a hot spot both at home and abroad. During the pathogenesis of multiple sclerosis, many inhibitory factors are produced in the disintegrated axon myelin sheath. These inhibitors inhibit maturation and remyelination of nascent oligodendrocytes. The use of antibodies antagonizing these inhibitors was found to induce partial recovery of function in experimentally demyelinated rats. But its downstream signal transduction pathway is unknown. Contents of the invention

[0003] One of ...

Claims

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