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Biodegradable chitosan-based hydrogel and preparation method thereof

A technology of biodegradation and chitosan, which is applied in the fields of tissue engineering and drug controlled release, can solve the problems of strong irritation and side effects, and achieve the effect of enhanced solubility, simple preparation method and mild reaction conditions

Inactive Publication Date: 2014-08-27
SHENYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent [200810059134.5] although chitosan with good biocompatibility is used as the base material to prepare chitosan hydrogel, but in the preparation process, strong alkaline components such as potassium hydroxide and sodium hydroxide and urea are added. Strong irritating substances are bound to produce strong irritating and toxic side effects on the body during use

Method used

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Examples

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Effect test

preparation example Construction

[0020] The preparation method of this biodegradable chitosan-based hydrogel is realized according to the following steps:

[0021] First dissolve N-succinyl chitosan and hyaluronic acid in deionized water respectively, wherein the mass ratio of N-succinyl chitosan to deionized water, hyaluronic acid to deionized water is 1:80-100 and 0.5:100, at room temperature and under full stirring, after mixing the two for 1-5 minutes, a biodegradable chitosan-based hydrogel can be formed.

Embodiment 1

[0023] A biodegradable chitosan-based hydrogel is formed by mixing the following weight percentages: 70% of N-succinyl chitosan with an N-succinylation degree of 15%, and 30% of hyaluronic acid.

[0024] The preparation method of this biodegradable chitosan-based hydrogel is realized according to the following steps:

[0025] Weigh each component of the above-mentioned biodegradable chitosan-based hydrogel by weight percentage, dissolve them in deionized water respectively, wherein the mass ratios of N-succinyl chitosan and hyaluronic acid to deionized water are respectively 1:100 and 0.5:100, mix the two at room temperature and under full stirring, and form a hydrogel after 60s.

Embodiment 2

[0027] A biodegradable chitosan-based hydrogel, which is formed by mixing the following percentages by weight: 70% of N-succinyl chitosan with an N-succinylation degree of 20%, and 30% of hyaluronic acid;

[0028] The preparation method of this biodegradable chitosan-based hydrogel is realized according to the following steps:

[0029] Weigh each component of the above-mentioned biodegradable chitosan-based hydrogel according to the proportion by weight, and dissolve them in deionized water respectively, wherein the mass ratios of N-succinyl chitosan and hyaluronic acid to water are respectively 1: 90 and 0.5:100, at room temperature and under full stirring, mix the two, and form a biodegradable chitosan-based hydrogel after 90s.

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Abstract

The invention discloses biodegradable chitosan-based hydrogel and a preparation method thereof. The biodegradable chitosan-based hydrogel comprises, by weight, 65-100% of N-succinyl-chitosan and 0-35% of hyaluronic acid. The preparation method comprises the following steps of respectively dissolving the N-succinyl-chitosan and the hyaluronic acid in deionized water according to a mass ratio of N-succinyl-chitosan to deionized water of 1: 80-100 and a mass ratio of hyaluronic acid to deionized water of 0.5: 100, and carrying out full stirring at a room temperature for 1-5min to mix the two solutions so that the biodegradable chitosan-based hydrogel is formed. The preparation method has simple processes and mild reaction conditions, does not utilize any cross-linking agent and prevents toxic and side effects caused by the cross-linking agent in clinical use. The biodegradable chitosan-based hydrogel is stable for a long time, can be used in fields of drug carriers and biological tissue engineering and has a wide application prospect.

Description

technical field [0001] The invention relates to a biodegradable chitosan-based hydrogel and a preparation method thereof, which can be applied to the fields of drug controlled release and tissue engineering. Background technique [0002] Hydrogel is an intersecting polymer network structure with a large number of hydrophilic groups. These network structures have strong hydrophilicity, but due to the chemical bonds or physical bonds formed between polymer chains, these network structures will not be dissolved by water. But the penetration of water into these networks causes them to swell, forming hydrogels. Fully water-swellable hydrogels have the same physical properties as living tissues, such as softness, elasticity, and low interfacial tension with water or bioengineering fluids. The fully swollen hydrogel minimizes irritation to surrounding tissues after implantation due to its good elasticity. The low surface tension between the hydrogel surface and body fluids minim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08J3/075A61K47/36
Inventor 曾敬
Owner SHENYANG NORMAL UNIV
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