Disposable supporting cell culture system for sterile cell culture bag

A cell culture, disposable technology, applied in tissue cell/virus culture devices, biochemical instruments, biochemical equipment and methods, etc., can solve the problems of complex cleaning in place, low cell growth density, limited surface area, etc., and achieve gas The effect of high conduction rate, avoiding cross-contamination, and reducing preparation time

Active Publication Date: 2014-09-03
奥星制药设备(石家庄)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Spinner bottle culture has the following problems: limited surface area, low cell growth density; unstable monitoring and control of environmental conditions (pH, dissolved oxygen, etc.) during culture, affecting product quality; high labor intensity, large space occupation, and high pollution rate
[0005] Stainless steel tank cultivation has

Method used

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  • Disposable supporting cell culture system for sterile cell culture bag
  • Disposable supporting cell culture system for sterile cell culture bag
  • Disposable supporting cell culture system for sterile cell culture bag

Examples

Experimental program
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Embodiment Construction

[0028] The supporting cell culture system of the disposable aseptic cell culture bag provided by the invention is as follows: figure 1 As shown, the specific structure diagram is shown in figure 2 As shown, it is mainly composed of a stirring unit, a support pipeline, a temperature control unit, a gas circuit control unit and a controller. The stirring unit, temperature control unit, and gas path control unit are connected through the bracket pipeline; the controller unit automatically controls the above four units through PLC, and conducts human-computer interaction through the touch screen, which can realize the stirring speed, temperature, and temperature of the culture bag. pH, dissolved oxygen and other automatic control functions, and has data recording and query functions.

[0029] Such as image 3 and Figure 4 As shown, an electrical cabinet frame 1 is arranged on the outside of the disposable sterile cell culture bag matching cell culture system, and the electric...

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Abstract

The invention provides a disposable supporting cell culture system for a sterile cell culture bag. The disposable supporting cell culture system comprises a stirring unit, a bracket pipeline, a temperature control unit, a gas path control circuit and a controller unit for controlling the four units, wherein the bracket pipeline is respectively connected with the stirring unit, the temperature control unit and the gas path control unit, and used for providing a channel for gas and liquid needed for the system; the stirring unit is provided with a stirring paddle which is integrated with a hollow gas distributor; the hollow gas distributor is connected with the gas path control unit; the hollow gas distributor comprises a micro air bubble distributor arranged on the lower part of the stirring paddle and a ventilating pipe arranged inside the stirring paddle. The system is used for lowering the labor intensity, staff needed for production and GMP (good manufacturing practice) production workshop area are greatly lower than those of the conventional production equipment, thereby facilitating realizing quicker refit for conveniently operating novel flow.

Description

technical field [0001] The invention relates to a cell culture system, in particular to a cell culture system matched with a disposable aseptic cell culture bag. Background technique [0002] Large-scale culture technology (large-scale culture technology) refers to the technology of cultivating cells at a high density in a cell bioreactor (bioreactor) under artificial conditions (setting pH, temperature, dissolved oxygen, etc.) for the production of biological products. [0003] At present, large-scale cell culture mainly adopts spinner bottle culture system and stainless steel tank culture system. [0004] Spinner bottle culture has the following problems: limited surface area, low cell growth density; unstable monitoring and control of environmental conditions (pH, dissolved oxygen, etc.) during culture, affecting product quality; high labor intensity, large space occupation, and high pollution rate. [0005] Stainless steel tank culture has the following problems: the ne...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/38C12M1/36C12M1/34C12M1/04C12M1/02
CPCC12M23/14C12M23/28C12M29/06C12M29/08C12M41/12C12M41/26C12M41/32C12M41/42
Inventor 何国强陈跃武闫永辉邓哲刘利科梁志国胡志威
Owner 奥星制药设备(石家庄)有限公司
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