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Synthesis method of tetrabromobisphenol A analog-tetrabromobisphenol A hexanoic acid

A technology of tetrabromobisphenol and synthetic method, which is applied in the field of synthesis of tetrabromobisphenol A analog tetrabromobisphenol A hexanoic acid, can solve the problems of expensive instruments, long detection time, complicated sample processing, etc., and achieve the synthetic steps Concise, meet the needs of immune research, and the effect of high product purity

Inactive Publication Date: 2014-09-10
JIANGNAN UNIV
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Problems solved by technology

[0007] Although the existing instrument detection method has the advantages of high sensitivity and wide application range, the sample pretreatment is complicated, the required equipment is expensive, the cost is high, and the detection time is long. Therefore, it is necessary to study specificity, high sensitivity, and low price. , a fast and easy immunoassay technique

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  • Synthesis method of tetrabromobisphenol A analog-tetrabromobisphenol A hexanoic acid
  • Synthesis method of tetrabromobisphenol A analog-tetrabromobisphenol A hexanoic acid
  • Synthesis method of tetrabromobisphenol A analog-tetrabromobisphenol A hexanoic acid

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Embodiment Construction

[0023] Add 1g, 1.84mmol of the compound tetrabromobisphenol A (TBBPA) into a 50mL round bottom flask, then add 20mL of N,N-dimethylformamide DMF, after the tetrabromobisphenol A is dissolved, add 3.68mmol 0.1M NaOH solution, placed at room temperature for later use. 1.84mmol of 6-bromohexanoic acid was dissolved in 3mL of DMF, then added dropwise to the mixed solution of tetrabromobisphenol A and NaOH, and reacted at 65°C for 2 hours. After the reaction, add water to the reaction solution, and adjust the pH to 1-2 with hydrochloric acid , obtained a precipitate, extracted with ethyl acetate, washed the organic phase three times with water, concentrated to obtain the product, and separated by column chromatography to obtain the target compound tetrabromobisphenol A hexanoic acid.

[0024] Characterization of tetrabromobisphenol A hexanoic acid:

[0025] The substance and purity identification of tetrabromobisphenol A hexanoic acid are characterized by means of ultra-high perfo...

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Abstract

The invention relates to a synthesis method of a tetrabromobisphenol A analog-tetrabromobisphenol A hexanoic acid, belonging to the technical field of biochemical engineering. The method comprises the following steps: carrying out one-step chemical reaction on the raw material 6-bromohexanoic acid to obtain the tetrabromobisphenol A analog-tetrabromobisphenol A hexanoic acid, and carrying out liquid chromatography-mass spectrometry to identify and analyze the important intermediate product and end product. The method successfully synthesizes the tetrabromobisphenol A analog-tetrabromobisphenol A hexanoic acid by using safe and effective synthesis steps, provides favorable conditions for establishing the tetrabromobisphenol A enzyme-linked immunosorbent assay analysis process, and satisfies the national demands for the research.

Description

technical field [0001] The invention relates to a method for synthesizing tetrabromobisphenol A hexanoic acid, which is a tetrabromobisphenol A analogue, and belongs to the technical field of biochemistry. Background technique [0002] Tetrabromobisphenol A (TetrabromobisPhenolA, TBBPA) is currently the world's largest brominated flame retardant, accounting for about 60% of the total brominated flame retardant market. Its structure is as follows: [0003] . [0004] At present, TBBPA pollution has attracted the attention of the international community. TBBPA pollution has been reported in non-biological samples such as soil, sediment and air, and biological samples such as aquatic organisms and wild animals. It has also been reported in samples such as human plasma and breast milk. TBBPA was detected. [0005] Tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCDD) are common brominated flame retardants, and their pollution hazards are obvious. Its polluting a...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/367C07C59/68
CPCC07C51/367C07C59/68
Inventor 匡华胥传来余丽徐丽广马伟刘丽强宋珊珊吴晓玲
Owner JIANGNAN UNIV
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