Traditional Chinese medicinal composition for treating insomnia and application thereof
A composition and technology for insomnia, applied in the field of medicine, can solve problems such as dependence and side effects, memory loss, central nervous system dysfunction, etc., and achieve the effect of being suitable for long-term use, reducing toxic and side effects, and having small toxic and side effects
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Embodiment 1
[0020] 1 Materials and methods
[0021] 1.1 Diagnostic criteria of the disease Western medicine diagnostic criteria refer to "Practical Internal Medicine", "Psychiatry", "Diagnostic Criteria for Internal Medicine Diseases", ICD-10F51.0 diagnostic criteria for insomnia: ①Sleep disorders: including difficulty falling asleep, intermittent wakefulness, Dreaminess, sleepiness, early awakening, inability to fall back to sleep after waking up, or even insomnia all night. ②The sleep disorders mentioned above occur at least 3 times a week and last for more than 4 weeks. ③ Symptoms such as fatigue, lack of energy, dizziness, dizziness, palpitation and upset during the day will affect social activities such as work and study.
[0022] TCM Syndrome Differentiation Standards Refer to the "Shanghai TCM Special Diagnosis and Treatment Program for Insomnia" formulated by the Sleep Disease Research Institute of Shanghai TCM Hospital.
[0023] Liver depression and blood stasis: emotional disp...
Embodiment 2
[0084] Influence of the Chinese medicine composition of the present invention on neurotransmitters and hormones in the serum of sleep-deprived rats
[0085] 1. Materials and methods
[0086] 1.1 Source of experimental animals Shanghai Xipuer-Bikay Laboratory Animal Co., Ltd. provided SD rats, SPF grade, male, 4-week-old rats, weighing 180-220 g, certificate number: 2008001635587.
[0087] Grouping and sample size: Normal control group (group A), sleep deprivation group (group B), Ganmailongmu decoction sleep deprivation group (group C), and Ganmailongmu decoction group (group D). After adaptive feeding for 3 days, the rats were randomly divided into 4 groups with 11 rats in each group by the random number generator in EXCEL.
[0088] Administration method and observation content After the rats were fed adaptively for 3 days, they were randomly divided into 4 groups, Group A and Group B were given 0.9% sodium chloride injection; Groups C and D were given Ganmai Longmu Decoctio...
Embodiment 3
[0151] 1 Materials and methods
[0152] 1.1 The diagnostic criteria of the disease Western medicine diagnostic criteria are the same as in Example 1
[0153] 1.2 TCM Syndrome Differentiation Standard Same as Example 1
[0154] 1.3 inclusion criteria Same as Example 1
[0155] 1.4 Exclusion criteria Same as Example 1
[0156] 1.5 Types of insomnia Same as Example 1
[0157] 1.6 Treatment methods
[0158] Chinese Medicine Group
[0159] Group (1): Huai wheat 26 grams, licorice 10 grams, flavescens 11 grams, cicada 5 grams, calcined keel 28 grams
[0160] Group (2): 28 grams of Huai wheat, 8 grams of licorice, 10 grams of sophora, 7 grams of cicada, 26 grams of calcined keel
[0161] Group (3): Huai wheat 27 grams, licorice 9 grams, flavescens 9 grams, cicada 6 grams, calcined keel 27 grams
[0162] Group (4): 26 grams of Huai wheat, 10 grams of licorice, 11 grams of sophora, 5 grams of cicada, 28 grams of calcined keel, 8 grams of soft Bupleurum, 13 grams of Guangyujin, 1...
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