Traditional Chinese medicinal composition for treating insomnia and application thereof

A composition and technology for insomnia, applied in the field of medicine, can solve problems such as dependence and side effects, memory loss, central nervous system dysfunction, etc., and achieve the effect of being suitable for long-term use, reducing toxic and side effects, and having small toxic and side effects

Inactive Publication Date: 2014-09-24
SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used are benzodiazepines (BDZ), such as estazolam, alprazolam, clonazepam, etc., all have sedative hypnotic and anti-anxiety effects, but also have obvious dependence and side effects at the same time, which can cause Central nervous system dysf...

Method used

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  • Traditional Chinese medicinal composition for treating insomnia and application thereof
  • Traditional Chinese medicinal composition for treating insomnia and application thereof
  • Traditional Chinese medicinal composition for treating insomnia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1 Materials and methods

[0021] 1.1 Diagnostic criteria of the disease Western medicine diagnostic criteria refer to "Practical Internal Medicine", "Psychiatry", "Diagnostic Criteria for Internal Medicine Diseases", ICD-10F51.0 diagnostic criteria for insomnia: ①Sleep disorders: including difficulty falling asleep, intermittent wakefulness, Dreaminess, sleepiness, early awakening, inability to fall back to sleep after waking up, or even insomnia all night. ②The sleep disorders mentioned above occur at least 3 times a week and last for more than 4 weeks. ③ Symptoms such as fatigue, lack of energy, dizziness, dizziness, palpitation and upset during the day will affect social activities such as work and study.

[0022] TCM Syndrome Differentiation Standards Refer to the "Shanghai TCM Special Diagnosis and Treatment Program for Insomnia" formulated by the Sleep Disease Research Institute of Shanghai TCM Hospital.

[0023] Liver depression and blood stasis: emotional disp...

Embodiment 2

[0084] Influence of the Chinese medicine composition of the present invention on neurotransmitters and hormones in the serum of sleep-deprived rats

[0085] 1. Materials and methods

[0086] 1.1 Source of experimental animals Shanghai Xipuer-Bikay Laboratory Animal Co., Ltd. provided SD rats, SPF grade, male, 4-week-old rats, weighing 180-220 g, certificate number: 2008001635587.

[0087] Grouping and sample size: Normal control group (group A), sleep deprivation group (group B), Ganmailongmu decoction sleep deprivation group (group C), and Ganmailongmu decoction group (group D). After adaptive feeding for 3 days, the rats were randomly divided into 4 groups with 11 rats in each group by the random number generator in EXCEL.

[0088] Administration method and observation content After the rats were fed adaptively for 3 days, they were randomly divided into 4 groups, Group A and Group B were given 0.9% sodium chloride injection; Groups C and D were given Ganmai Longmu Decoctio...

Embodiment 3

[0151] 1 Materials and methods

[0152] 1.1 The diagnostic criteria of the disease Western medicine diagnostic criteria are the same as in Example 1

[0153] 1.2 TCM Syndrome Differentiation Standard Same as Example 1

[0154] 1.3 inclusion criteria Same as Example 1

[0155] 1.4 Exclusion criteria Same as Example 1

[0156] 1.5 Types of insomnia Same as Example 1

[0157] 1.6 Treatment methods

[0158] Chinese Medicine Group

[0159] Group (1): Huai wheat 26 grams, licorice 10 grams, flavescens 11 grams, cicada 5 grams, calcined keel 28 grams

[0160] Group (2): 28 grams of Huai wheat, 8 grams of licorice, 10 grams of sophora, 7 grams of cicada, 26 grams of calcined keel

[0161] Group (3): Huai wheat 27 grams, licorice 9 grams, flavescens 9 grams, cicada 6 grams, calcined keel 27 grams

[0162] Group (4): 26 grams of Huai wheat, 10 grams of licorice, 11 grams of sophora, 5 grams of cicada, 28 grams of calcined keel, 8 grams of soft Bupleurum, 13 grams of Guangyujin, 1...

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Abstract

The invention relates to a traditional Chinese medicinal composition for treating insomnia. The composition is prepared from the following raw medicinal materials in parts by weight: 27 parts of Huai wheat, 9 parts of liquorice, 9 parts of radix sophorae flavescentis, 6 parts of periostracum cicada, 9 parts of bombyx batryticatus, 9 parts of rhizona gastrodiae, 15 parts of tender uncaria rhynchophylla, 30 parts of kudzu vine root, 12 parts of ligusticum wallichii, 9 parts of soft radix bupleuri, 27 parts of calcined keel, 12 parts of radix curcumae, 9 parts of rhizoma acori graminei, 12 parts of stir-baked fructus gardeniae, 12 parts of scutellaria baicalensis, 12 parts of red peony root, 12 parts of radix paeoniae alba, 27 parts of radix salviae miltiorrhizae, 27 parts of cortex albiziae and 30 parts of tuber fleeceflower stem. The invention also provides an application of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition has the effects of calming the liver and resolving depression, clearing heat, activating blood circulation and calming nerves, has a good curative effect in clinical treatment of liver stagnation type insomnia, and can be used for regulating neurotransmitter and hormone disturbance.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for treating insomnia and its application. Background technique [0002] Insomnia refers to the occurrence of difficulty in falling asleep, repeated easy to wake up, and early awakening under the condition of good sleep conditions, and more than 3 nights a week for more than 1 month in a row, because the time and quality of sleep cannot meet the body's physiological A group of syndromes in which daytime dysfunction occurs as a result of need. Insomnia is equivalent to "insomnia" in traditional Chinese medicine. In the past ten years, with the acceleration of social development and the intensification of competition, the incidence of insomnia among the population has risen rapidly. In 2002, it was reported that about one-third of American adults had difficulty sleeping, and 10-15% showed obvious symptoms of insomnia. , Nanjing and oth...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/9066A61P25/20A61K35/64A61K35/02
Inventor 严晓丽王国华徐建许红许良王惠茹张雯静李志敏王翘楚
Owner SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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