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Preparation process of compound glabrous greenbrier rhizome granules

A preparation process, the technology of Smilax smilax, applied in the field of preparation of compound Smilax smilax granules, can solve the problems of poor repeatability of molding process, high cost, unreasonable design of water extraction process, etc.

Inactive Publication Date: 2014-10-01
吴新荣 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of compound Smilax granules mainly includes steps such as water extraction, clarification, and granule forming. In practice, it is found that the water extraction process design in the existing production process of Compound Smilax granules is unreasonable and the extraction rate is low. The alcohol-precipitation method for impurity removal not only consumes a large amount of alcohol and is costly, but also the particles obtained after alcohol precipitation have strong hygroscopicity, poor repeatability of the molding process, and high production costs

Method used

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  • Preparation process of compound glabrous greenbrier rhizome granules
  • Preparation process of compound glabrous greenbrier rhizome granules
  • Preparation process of compound glabrous greenbrier rhizome granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Take by weighing 45 parts of raw material Smilax smilax, 15 parts of Achyranthes bidentata, 15 parts of fennel, 15 parts of Wang Buliuxing, and 15 parts of Arrowhead mushroom, and prepare compound Smilax smilax granules according to the following process steps:

[0067] (1) Water extraction: take by weight 45 parts of raw material Smilax tuckahoe, 15 parts of Achyranthes bidentata, 15 parts of fennel, 15 parts of vaccinia, 15 parts of Arrowhead mushroom, add 8 times of water and soak for 30 minutes, Boil for 1 hour, pass through three layers of gauze to obtain water extract;

[0068] (2) Clarification: Evaporate and concentrate the water extract prepared in step B to a concentration of 1:5 (crude drug g / medicine liquid mL), stir at 50°C (100r min -1 ) condition, add 5mL of viscose solution of A component of ZTC1+1-Ⅱ clarifier with a concentration of 1%, and then stir once every 30min or so; after 2h, stir at 60°C (100r·min Add 2.5mL of B-component viscose liquid with a...

Embodiment 2

[0071] Take by weighing 45 parts of raw material Smilax smilax, 15 parts of Achyranthes bidentata, 15 parts of fennel, 15 parts of Wang Buliuxing, and 15 parts of Arrowhead mushroom, and prepare compound Smilax smilax granules according to the following process steps:

[0072] (1) Water extraction: take by weight 45 parts of raw material Smilax tuckahoe, 15 parts of Achyranthes bidentata, 15 parts of fennel, 15 parts of vaccinia, 15 parts of Arrowhead mushroom, add 10 times of water and soak for 30 minutes, Boil for 2 hours, pass through three layers of gauze, add 10 times more water to decoct twice, filter, and combine the filtrate three times;

[0073] (2) Clarification: Evaporate and concentrate the water extract prepared in step B to a concentration of 1:8 (crude drug g / medicine liquid mL), stir at 70°C (100r min -1 ) conditions, add 30mL of viscose solution of A component of ZTC1+1-Ⅱ clarifier with a concentration of 1%, and then stir once every 30min; Next, add 15mL of ...

Embodiment 3

[0076] Take by weighing 45 parts of raw material Smilax smilax, 15 parts of Achyranthes bidentata, 15 parts of fennel, 15 parts of Wang Buliuxing, and 15 parts of Arrowhead mushroom, and prepare compound Smilax smilax granules according to the following process steps:

[0077] (1) Water extraction: take by weight 45 parts of raw material Smilax tuckahoe, 15 parts of Achyranthes bidentata, 15 parts of fennel, 15 parts of vaccinia, 15 parts of Arrowhead mushroom, add 12 times of water and soak for 30 minutes, Boil for 2 hours, pass through three layers of gauze, add 12 times of water to decoct twice, filter, and combine the filtrate three times;

[0078] (2) Clarification: Evaporate and concentrate the water extract obtained in step B to a concentration of 1:12 (crude drug g / medicine liquid mL), stir at 90°C (100r min -1 ) under the condition, add 50mL of viscose solution of A component of ZTC1+1-Ⅱ clarifier with a concentration of 1%, and then stir once every 30min or so; after...

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Abstract

The invention relates to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation process of compound glabrous greenbrier rhizome granules. According to the preparation process provided by the invention, a water extraction process is optimized, so that the extraction ratio of the water extraction process is greatly improved; a ZTC1+1-II type natural clarifying agent is adopted in a clarifying process and is used for replacing ethyl alcohol in a water extract and alcohol precipitation process of Chinese herbal medicine preparation, so that the traditional water extract and alcohol precipitation process is simplified, the production period is shortened and the cost is lowered but also the clarifying efficiency is improved and the good repeatability of a granule forming process is realized. Thus, the production cost is lowered. Compared with the granules prepared by using the existing technology, the compound glabrous greenbrier rhizome granules obtained by using the preparation process provided by the invention are high in extract yield, high in effective ingredient content, low in hygroscopicity and high in stability.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a preparation process of compound Smilax smilax granules. Background technique [0002] Compound Smilax granules have the effects of venting turbidity and eliminating evil, dispelling dampness and clearing heat, and are mainly used for the treatment of hyperuricemia and gout. The preparation process of compound Smilax smilax granules mainly includes steps such as water extraction, clarification, and granule forming. In practice, it is found that the water extraction process design in the existing compound Smilax smilax granules production process is unreasonable and the extraction rate is low. The alcohol-precipitation method for impurity removal not only consumes a large amount of alcohol and has high cost, but also the particles obtained after alcohol precipitation have strong hygroscopicity, poor repeatability of the molding process, and high prod...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K36/90A61K9/16A61K47/30A61P19/06
Inventor 吴新荣
Owner 吴新荣
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