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Fengshiding capsule and preparation method thereof

A technology for rheumatoid arthritis and rheumatoid arthritis, which can be used in capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve problems such as unsatisfactory curative effect, low curative effect, and slow dissolution.

Inactive Publication Date: 2014-10-29
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commercially available Fengshiding Capsules have unsatisfactory curative effect due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow dissolution and low curative effect.

Method used

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  • Fengshiding capsule and preparation method thereof
  • Fengshiding capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 300g of Xiangjia skin, 500g of star anise maple, 100g of Xu Changqing, grind them into 60 mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, extraction pressure 30Mpa, extraction temperature 30°C, separator pressure 10Mpa, separator temperature 50°C, separation time For 2 hours, the carbon dioxide flow rate is 40L per hour to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; add 150g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take mixed dry paste powder, aspartame 45g, maltose 45g, mix well, wet granulate with 50% ethanol, dry at 60°C, add 7g sodium carboxymethyl starch, 1g magnesium stearate, granulate, pack Go into capsule, make 500, make Fengshiding capsule.

specific Embodiment 2

[0022] Take 300g of Xiangjiapi, 500g of star anise maple, and 100g of Xu Changqing, grind them into 60 mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, extraction pressure 40Mpa, extraction temperature 40°C, separator pressure 20Mpa, separator temperature 60°C, separation time For 4 hours, the carbon dioxide flow rate is 50L per hour to obtain the extract; take the extract and dry it under reduced pressure at 80°C to obtain a dry paste; add 200g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take the mixed dry cream powder, aspartame 55g, maltose 55g, mix well, wet granulate with 70% ethanol, dry at 80°C, add 9g sodium carboxymethyl starch, 3g magnesium stearate, granulate, pack Go into capsule, make 500, make Fengshiding capsule.

Embodiment 3

[0024] Take 300g of Xiangjia skin, 500g of star anise maple, and 100g of Xu Changqing, grind them into 60 mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, extraction pressure 35Mpa, extraction temperature 35°C, separator pressure 15Mpa, separator temperature 55°C, separation time For 3 hours, the carbon dioxide flow rate is 45L per hour to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 175g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take the mixed dry cream powder, aspartame 50g, maltose 50g, mix well, wet granulate with 60% ethanol, dry at 70°C, add 8g sodium carboxymethyl starch, 2g magnesium stearate, granulate, pack Go into capsule, make 500, make Fengshiding capsule.

[0025] The above examples illustrate that Fengshiding capsules can be made by adopting the extrem...

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Abstract

The invention discloses a fengshiding capsule and a preparation method thereof. The fengshiding capsule is characterized in that 300g of cortex periplocae, 500g of alangium platanifolium, 100g of paniculate swallowwort root are taken and extracted by adopting a carbon dioxide supercritical extraction method, dried under reduced pressure, and crushed into nano dry paste by a high-energy nano impact mill, and functional auxiliary materials are added to prepare the fengshiding capsule. Disintegrating time of the fengshiding capsule disclosed by the invention is remarkably shortened, and curative effect of the capsule is remarkably superior to that of a commercially available fengshiding capsule, so that positive effects are achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Fengshiding capsule and a preparation method thereof. Background technique [0002] Fengshiding Capsule has the effects of promoting blood circulation and dredging collaterals, eliminating numbness and relieving pain. For rheumatoid arthritis, rheumatoid arthritis, cervical costal neuralgia, sciatica. The curative effect of commercially available Fengshiding Capsules is not ideal due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow dissolution and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides Fengshiding capsules with fast dissolution rate and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follows: [0005] Take 300g of Xiangjia skin, 500g of star anise m...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61K9/48A61P29/00A61P19/02A61P25/02
Inventor 宋剑丽
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD