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Pharmaceutical composition with bone mineral density increasing function and preparation method thereof

A technology for increasing bone density and composition, which is applied in the application field of preparing medicine and health food, and can solve the problems of increasing bone fragility, osteomalacia, reducing bone turnover rate, etc.

Active Publication Date: 2014-11-05
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For osteoporosis, at present, drugs such as estrogen, calcium, active vitamin D, calcitonin and fluoride are most used in clinical treatment of this disease. Ubiquitous, such as long-term use of synthetic estrogen drugs can lead to abnormal hyperplasia of the breast and endometrium, sequential use of bisphosphonates can reduce bone turnover rate and increase bone fragility, and fluoride alone can cause osteomalacia , allergies to vitamin D and calcitonin

Method used

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  • Pharmaceutical composition with bone mineral density increasing function and preparation method thereof
  • Pharmaceutical composition with bone mineral density increasing function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1 Capsules

[0073] [Prescription] Epimedium 25kg, Rehmannia glutinosa 22kg, Salvia miltiorrhiza 10kg, Achyranthes bidentata 30kg, biological calcium carbonate 1kg and casein phosphopeptide 5kg.

[0074] 【Preparation】

[0075] (1) Take Epimedium according to the selected weight and add 6 times the mass concentration of the drug weight to extract 3 times with 80% ethanol, each 1h, merge and filter the gained extract, reclaim the ethanol, then concentrate the gained filtrate under reduced pressure to Concentrate I with a relative density of 1.15 at 60°C, set aside;

[0076] (2) Weigh Rehmannia glutinosa and Achyranthes bidentata according to the selected weight, mix them evenly, add purified water 10 times the weight of the drug to extract once, for 3 hours each time, combine and filter the obtained extract, and then concentrate the obtained filtrate to 80°C under reduced pressure Concentrate II with a relative density of 1.20, for later use;

[0077] (3) Accor...

Embodiment 2

[0079] Example 2 tablet

[0080] [Prescription] Epimedium 40kg, Rehmannia glutinosa 15kg, Salvia miltiorrhiza 30kg, Achyranthes bidentata 10kg, biological calcium carbonate 10kg and casein phosphopeptide 1kg.

[0081] 【Preparation】

[0082] (1) Take Epimedium according to the selected parts by weight and add 8 times the mass concentration of the drug weight to extract with 50% ethanol once, 3 hours each time, merge and filter the obtained extract, reclaim the ethanol, and then decompress the obtained filtrate Concentrate to a concentrated solution I with a relative density of 1.25 at 60°C and set aside;

[0083] (2) Take rehmannia glutinosa and Achyranthes bidentata in selected parts by weight, mix and add 6 times the purified water of drug weight to extract 3 times, each time for 1 hour, merge and filter the obtained extract, and then concentrate the obtained filtrate to 80% under reduced pressure. Concentrate II with a relative density of 1.20 at ℃, for later use;

[0084...

Embodiment 3

[0086] Embodiment 3 mixture

[0087] [Prescription] Epimedium 25kg, Rehmannia glutinosa 22kg, Salvia miltiorrhiza 16kg, Achyranthes bidentata 20kg, biological calcium carbonate 5kg and casein phosphopeptide 3kg.

[0088] 【Preparation】

[0089] (1) Take Epimedium Herba according to selected parts by weight and add 10 times the mass concentration of drug weight to extract 2 times with 75% ethanol, each 1.5h, merge and filter the gained extract, reclaim ethanol, then reduce the gained filtrate Concentrate under high pressure to the concentrated solution I with a relative density of 1.20 at 60°C for subsequent use;

[0090] (2) Weigh Rehmannia glutinosa and Achyranthes bidentata according to the selected parts by weight, mix them evenly, add purified water to extract twice, add purified water 10 times the weight of the drug for 2 hours for the first time, and extract purified water 8 times the weight of the drug for the second time 1h, combine the extracts and filter, concentrat...

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Abstract

The invention provides a pharmaceutical composition with a bone mineral density increasing function and a preparation method thereof. The bulk drugs include: 15-40 parts by weight of epimedium, 15-40 parts by weight of Radix Rehmanniae Preparata, 10-30 parts by weight of Salvia Miltiorrhiza, 10-30 parts by weight of achyranthes bidentata, 1-10 parts by weight of biological calcium carbonate and 1-5 parts by weight of casein phosphopeptide. Preparations prepared from the pharmaceutical composition have the function of increasing bone mineral density. With significant effects in prevention and treatment of osteoporosis, the pharmaceutical composition can be used for preparing drugs or health food and food.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition capable of increasing bone density, a preparation method thereof, and an application in the preparation of medicines and health foods. Background technique [0002] Osteoporosis is a complex chronic lesion process caused by multiple factors. It is a common disease and frequently-occurring disease among middle-aged and elderly people. It is one of the most common and serious complications of osteoporosis, which greatly affects people's quality of life. [0003] Osteoporosis has a high incidence rate and great harm, and has been highly valued by the global medical community. The World Health Organization lists it as one of the three major geriatric diseases. At present, about 200 million people in the world suffer from osteoporosis, and its incidence rate has jumped to the seventh place among common diseases and frequently-occurring diseases....

Claims

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Application Information

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IPC IPC(8): A61K38/17A23L1/29A61P19/10A61K36/804A61K36/537A61K36/296A61K36/21A61K33/10A23L33/00
Inventor 王丽菊洪绯罗志毅林小红郑玉清
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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